US4568542A
Expired / Lapsed
US
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Vaccine compositions
Assignee: LEE BIOMOLECULAR RESEARCH LABRATORIES Inc
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Filing: 1981-06-09
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Granted: 1986-02-04
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Expires: 2001-06-09
Abstract
Abstract The present invention describes the inactivation of target cells by treatment of said cells with psoralens and irradiation with long wave length ultraviolet light. The inactivated cells are shown to be antigenic and are shown to be non-infective. These cells are useful as target antigens for in vitro assays of cellular immunity. Diagnostic kits containing the inactivated, target cells are prepared for use in serologic assays. Since the inactivated cells are immunogenic and non-infective, they are also useful as vaccines.
Inventors
- 👤 Lee H. Kronenberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:58
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/12; A61K39/145; A61K39/0005; A61K39/0011; A61K39/245; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/5005; G01N33/5091; G01N33/53; G01N33/543; G01N33/554; G01N33/569; A61K2039/51; A61K2039/515; A61K2039/525; A61K2039/5252; A61K2039/555; A61K2039/55511; A61K2039/55566; C; C12; C12N; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16611; C12N2710/16634; C12N2760/00; C12N2760/00011; C12N2760/16011; C12N2760/16111; C12N2760/16134
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
58 words
An immunologically reactive vaccine composition comprising a physiologically acceptable medium for vaccine use and effective amounts of inactivated, non-infective virus-containing normal cells or tumor cells having cell-associated antigens capable of eliciting an immunological response and having had DNA or RNA contained therein covalently bonded to psoralen or a psoralen derivative in the presence of long wavelength ultraviolet light.
Claim 2
Dependent Claim
58 words
An immunologically reactive vaccine composition comprising a physiologically acceptable medium for vaccine use and effective amounts of inactivated, non-infective virus-containing normal cells or tumor cells having cell-associated antigens capable of eliciting an immunological response and having had DNA or RNA contained therein covalently bonded to psoralen or a psoralen derivative in the presence of long wavelength ultraviolet light.
Claim 3
Dependent Claim
14 words
The immunologically reactive composition of claim 1 wherein the virus is Herpes simplex virus.
Claim 4
Dependent Claim
13 words
The immunologically reactive composition of claim 1 wherein the virus is influenza virus.
Claim 5
Dependent Claim
14 words
The immunologically reactive composition of claim 2 wherein the cells are rabbit kidney cells.
Claim 6
Dependent Claim
16 words
The immunologically reactive composition of claim 3 wherein the cells are Madin Darby canine kidney cells.
Claim 7
Dependent Claim
14 words
The immunologically reactive vaccine composition of claim 1 wherein the cells are normal cells.
Claim 8
Dependent Claim
14 words
The immunologically reactive vaccine composition of claim 1 wherein the cells are tumor cells.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-02-03 | 1989-08-05 | 1990-02-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-02-03 | 1993-08-05 | 1994-02-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-02-03 | 1997-08-05 | 1998-02-04 | $7700.00 | Window Closed / Lapsed |