US4567289A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted pyranone inhibitors of cholesterol synthesis
Assignee: Merck and Co Inc
•
Filing: 1984-04-25
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Granted: 1986-01-28
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Expires: 2004-04-25
Abstract
Abstract The methyl, ethyl, n-propy, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihyd roxy-6-heptenoic acid of structural formula: <IMAGE> are HMG-CoA reductase inhibitors useful in the treatment of conditions associated with hypercholesterolemia.
Inventors
- 👤 Alvin K. Willard
- 👤 Frederick C. Novello
- 👤 William F. Hoffman
- 👤 Edward J. Cragoe, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 03:25
CPC Classifications
C; C07; C07D; C07D309/00; C07D309/16; C07D309/28; C07D309/30; C07C; C07C69/00; C07C69/66; C07C69/73; C07C69/732
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
15 words
The methyl, ethyl, n-propyl, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acid of structural formula: ##STR9##
Claim 2
Dependent Claim
15 words
The methyl, ethyl, n-propyl, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acid of structural formula: ##STR9##
Claim 3
Dependent Claim
9 words
The compound of claim 1 which is ethyl E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoate.
Claim 4
Dependent Claim
9 words
The compound of claim 1 which is 2-(acetylamino)-ethyl E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-27 | 1989-07-29 | 1990-01-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-27 | 1993-07-29 | 1994-01-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-27 | 1997-07-29 | 1998-01-28 | $7700.00 | Window Closed / Lapsed |