US4567177A
Expired / Lapsed
US
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Imidazoline derivatives as α2 -antagonists
Assignee: Synthelabo SA
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Filing: 1984-10-16
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Granted: 1986-01-28
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Expires: 2004-10-16
Abstract
Abstract Imidazoline derivatives of formula (I) ##STR1## in which n is 1 or 2, R is hydrogen, C 1 -C 3 alkyl or allyl group, and X is hydrogen, halogen atom, methyl or methoxy, in the form of enantiomers or mixtures thereof, and their pharmaceutically acceptable acid addition salts are useful as α 2 -antagonists.
Inventors
- 👤 Dennis Bigg
- 👤 Claude Morel
- 👤 Mireille Sevrin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 06:43
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/06; C07D223/00; C07D223/02; C07D223/04; C07D487/00; C07D487/02; C07D487/06
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
51 words
An imidazoline derivative, in the form of an enantiomer or a mixture thereof, of the formula (I) ##STR5## in which n is 1 or 2, R is hydrogen, C 1 -C 3 alkyl or allyl, and X is hydrogen, halogen, methyl or methoxy, or a pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
51 words
An imidazoline derivative, in the form of an enantiomer or a mixture thereof, of the formula (I) ##STR5## in which n is 1 or 2, R is hydrogen, C 1 -C 3 alkyl or allyl, and X is hydrogen, halogen, methyl or methoxy, or a pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
28 words
A pharmaceutical composition for treating depression comprising an anti-depressant effective amount of an imidazoline derivative or salt as claimed in claim 1 and a pharmaceutically acceptable diluent therefor.
Claim 4
Dependent Claim
29 words
A pharmaceutical composition for treating asthma comprising an asthma treating effective amount of an imidazoline derivative or salt as claimed in claim 1 and a pharmaceutically acceptable diluent therefor.
Claim 5
Dependent Claim
28 words
A pharamaceutical composition for treating obesity comprising a weight-lowering effective amount of an imidazoline derivative or salt as claimed in claim 1 and a pharmaceutically acceptable diluent therefor.
References Cited (Backward Citations)
US4411908A
Cited
EP0109285A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-27 | 1989-07-29 | 1990-01-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-27 | 1993-07-29 | 1994-01-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-27 | 1997-07-29 | 1998-01-28 | $7700.00 | Window Closed / Lapsed |