US4565807A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medicinal composition containing pirprofen and cyclodextrin and a method of use
Assignee: Novartis Corp
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Filing: 1983-07-11
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Granted: 1986-01-21
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Expires: 2003-07-11
Abstract
Abstract The invention relates to a new medicinal composition containing α-[3-chloro-4-(3-pyrrolin-1-yl)-phenyl]-propionic acid as the pharmacologically active ingredient, having analgesic and antiinflammatory properties, which composition has markedly improved properties, particularly with respect to taste and stability.
Inventors
- 👤 Kaneto Uekama
- 👤 Mikio Hanafusa
- 👤 Masashi Tatsumi
- 👤 Tohru Hibi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 22:05
CPC Classifications
B; B82; B82Y; B82Y5/00; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61K31/70; A61K31/715; A61K47/00; A61K47/50; A61K47/69; A61K47/6949; A61K47/6951; A61P; A61P25/00; A61P25/04; C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0012; C08B37/0015
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
26 words
A pharmaceutical composition comprising an analgesic, antiinflammatory and antipyretic effective amount of an inclusion compound of α-[3-chloro-4-(3-pyrrolin-1-yl)-phenyl]-propionic acid and a cyclodextrin, and a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
26 words
A pharmaceutical composition comprising an analgesic, antiinflammatory and antipyretic effective amount of an inclusion compound of α-[3-chloro-4-(3-pyrrolin-1-yl)-phenyl]-propionic acid and a cyclodextrin, and a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
22 words
A composition according to claim 1, wherein said pharmaceutically acceptable carrier comprises at least one pharmaceutically acceptable inorganic or organic basic substance.
Claim 4
Dependent Claim
37 words
A composition according to claim 2 wherein said basic substance is a member selected from the group consisting of an alkali metal hydroxide, phosphate, phosphite, carbonate, hydrogen carbonate, borate, and acetate; a basic amino acid; and piperizine.
Claim 5
Dependent Claim
34 words
A composition according to claim 2, wherein said pharmaceutically acceptable inorganic basic substance is a member selected from the group consisting of an alkali metal hydroxide, phosphate, phosphite, carbonate, hydrogen carbonate, borate and acetate.
Claim 6
Dependent Claim
28 words
A composition according to claim 2, wherein said pharmaceutically acceptable organic basic substance is a member selected from the group consisting of a basic amino acid and piperazine.
Claim 7
Dependent Claim
29 words
A method of treating pain comprising administering an analgesic, antiinflammatory and antipyretic effective amount of the composition according to claim 1, to a patient in need of the same.
Claim 8
Dependent Claim
29 words
A method of treating fever comprising administering an analgesic, antiinflammatory and antipyretic effective amount of the composition according to claim 1, to a patient in need of the same.
Claim 9
Dependent Claim
25 words
A method according to claim 6, wherein said composition contains a pharmaceutically acceptable carrier comprising at least one pharmaceutically acceptable inorganic or organic basic substance.
Claim 10
Dependent Claim
24 words
A method according to claim 7, wherein said composition contains a pharmaceutically acceptable carrier comprising at lest one pharmaceutically acceptable inorganic or organic substance.
Claim 11
Dependent Claim
37 words
A method according to claim 8 wherein said basic substance is a member selected from the group consisting of: an alkali metal hydroxide, phosphate, phosphite, carbonate, hydrogen carbonate, borate and acetate; a basic amino acid; and piperazine.
Claim 12
Dependent Claim
37 words
A method according to claim 9, wherein said basic substance is a member selected from the group consisting of: an alkali metal hydroxide, phosphate, phosphite, carbonate, hydrogen carbonate, borate and acetate; a basic amino acid; and piperazine.
Claim 13
Dependent Claim
9 words
An inclusion compound of α-[3-chloro-4-(3-pyrrolin-1-yl)-phenyl]-propionic acid and a cyclodextrin.
Claim 14
Dependent Claim
9 words
An inclusion compound of α-[3-chloro-4-(3-pyrrolin-1-yl)-phenyl]-propionic acid and a cyclodextrin.
Claim 15
Dependent Claim
12 words
An inclusion compound according to claim 12, wherein said cyclodextrin is β-cyclodextrin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-20 | 1989-07-22 | 1990-01-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-20 | 1993-07-22 | 1994-01-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-20 | 1997-07-22 | 1998-01-21 | $7700.00 | Window Closed / Lapsed |