US4565688A
Expired / Lapsed
US
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Quaternized phthalocyanin derivatives
Assignee: Bayer Corp
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Filing: 1983-11-14
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Granted: 1986-01-21
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Expires: 2003-11-14
Abstract
Abstract New phthalocyanin derivatives which can be used to differentiate basophils from other blood cells are disclosed. The compounds to which the present invention are quaternary salts of a substituted phthalocyanin structure wherein the substitutions are each independently hydrogen, sulfonate, or a C1-C7 hydrocarbon, optionally containing at least one heteroatom, with the proviso that at least one of them is <IMAGE> in which R1-R3 are each independently lower alkyls, cycloalkyls or olefins of which at least one is C2-C4 and two may join to form a ring; R4 is hydrogen or a C1-C3 alkyl; n is an integer from 1 to 6; M is a polyvalent metal ion. It is preferred that at least two and especially at least three substitutions have the structure so set forth.
Inventors
- 👤 Michael J. Malin
- 👤 Bernard Loev
- 👤 Deng R. Hwang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 19:10
CPC Classifications
C; C09; C09B; C09B47/00; C09B47/04; C09B47/32; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/5005; G01N33/5094
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
160 words
A compound having the formula ##STR8## wherein each of A 1 -A 4 , same or different, is hydrogen, sulfonate, hydroxyl or a C 1 -C 7 hydrocarbon, optionally containing at least one heteroatom, selected from alkoxy, cyano, carbalkoxy, a linear or branched, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon, an unsubstituted or substituted aryl or heteroaryl group, a benzyl radical or a benzyl substituted by oxygen or a nonalkylatable nitrogen or sulfur atom with the proviso that at least one of A 1 -A 4 is ##STR9## in which each of R 1 -R 3 , same or different, is lower alkyl, cycloalkyl or alkenyl, wherein at least one is C 2 -C 4 and two of R 1 -R 3 may join to form a ring; R 4 is hydrogen or a C 1 -C 3 alkyl; n is an integer from 2 to 6; M is a polyvalent metal ion; and X - is a water-soluble anion.
Claim 2
Dependent Claim
160 words
A compound having the formula ##STR8## wherein each of A 1 -A 4 , same or different, is hydrogen, sulfonate, hydroxyl or a C 1 -C 7 hydrocarbon, optionally containing at least one heteroatom, selected from alkoxy, cyano, carbalkoxy, a linear or branched, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon, an unsubstituted or substituted aryl or heteroaryl group, a benzyl radical or a benzyl substituted by oxygen or a nonalkylatable nitrogen or sulfur atom with the proviso that at least one of A 1 -A 4 is ##STR9## in which each of R 1 -R 3 , same or different, is lower alkyl, cycloalkyl or alkenyl, wherein at least one is C 2 -C 4 and two of R 1 -R 3 may join to form a ring; R 4 is hydrogen or a C 1 -C 3 alkyl; n is an integer from 2 to 6; M is a polyvalent metal ion; and X - is a water-soluble anion.
Claim 3
Dependent Claim
72 words
The compound of claim 1 wherein at least two of A 1 -A 4 are ##STR10## in which R 1 -R 3 are each independently lower alkyls of which at least one is a C 2 -C 4 alkyl; R 4 is hydrogen or a C 1 -C 3 alkyl; n is an integer from 2 to 6; M is a polyvalent metal ion; and X - is a water soluble anion.
Claim 4
Dependent Claim
72 words
The compound of claim 1 wherein at least three of A 1 -A 4 are ##STR11## in which R 1 -R 3 are each independently lower alkyls of which at least one is a C 2 -C 4 alkyl; R 4 is hydrogen or a C 1 -C 3 alkyl; n is an integer from 2 to 6; M is a polyvalent metal ion; and X - is a water soluble anion.
Claim 5
Dependent Claim
39 words
The compound of any one of claims 1, 2 or 3 wherein one of R 1 -R 3 is C 2 -C 4 and the other two are identical; R 4 is hydrogen; and n is 2 or 3.
Claim 6
Dependent Claim
26 words
The compound of any of claims 1, 2 or 3 wherein M is a polyvalent cation of copper, nickel, zinc, cobalt, magnesium, iron, manganese or chromium.
Claim 7
Dependent Claim
19 words
The compound of any of claims 1, 2 or 3 wherein X - is bromide, chloride, iodide or sulfate.
Claim 8
Dependent Claim
23 words
The compound of any of claims 1, 2 or 3 wherein at least one of R 1 -R 3 is ethyl or propyl.
Claim 9
Dependent Claim
78 words
A compound of claim 1 in which R 1 -R 3 are each independently lower alkyls of which at least one is ethyl, propyl or allyl and the other two are the same as each other; R 4 is hydrogen; n is 2 or 3; M is a polyvalent metal ion selected from cupric, nickel, zinc, cobalt, magnesium, ferric, ferrous, manganese or chromium; and X - is a water soluble anion selected from bromide, chloride, iodide or sulfate.
Claim 10
Dependent Claim
35 words
A composition for the determination of basophils in a sample, which composition comprises the compound of any of claims 1, 2, 3 or 8, lanthanum chloride and a surfactant effective to lyse red blood cells.
References Cited (Backward Citations)
US3210345A
Cited
US3954392A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-20 | 1989-07-22 | 1990-01-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-20 | 1993-07-22 | 1994-01-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-20 | 1997-07-22 | 1998-01-21 | $7700.00 | Window Closed / Lapsed |