US4564472A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3-Aminomethylene-2,4-pentanedione bis(thiosemicarbazone) derivatives, and their production and use
Assignee: Nihon Medi Physics Co Ltd
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Filing: 1983-06-30
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Granted: 1986-01-14
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Expires: 2003-06-30
Abstract
Abstract A radioactive diagnostic agent which comprises a physiologically active substance and a radioactive metallic element combined with a compound of the formula: ##STR1## wherein R 1 and R 2 are each hydrogen, C 1 -C 3 alkyl or phenyl. The agent is characteristic in having a high stability even after being administered into a human body and showing the substantially the same behavior as the physiologically active substance itself in a human body.
Inventors
- 👤 Nobuo Ueda
- 👤 Susumu Kondo
- 👤 Masaaki Hazue
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:11
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/081; A61K51/088; A61K2123/00
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
39 words
A physiologically active substance-combined compound comprising a compound of the formula: ##STR3## wherein R 1 and R 2 are each hydrogen, C 1 -C 3 alkyl or phenyl, and a physiologically active substance bound therewith by a chemical bond.
Claim 2
Dependent Claim
39 words
A physiologically active substance-combined compound comprising a compound of the formula: ##STR3## wherein R 1 and R 2 are each hydrogen, C 1 -C 3 alkyl or phenyl, and a physiologically active substance bound therewith by a chemical bond.
Claim 3
Dependent Claim
17 words
The physiologically active substance-combined compound according to claim 1, wherein the chemical bond is a carbonamide linkage.
Claim 4
Dependent Claim
17 words
The physiologically active substance-combined compound according to claim 1, wherein the chemical bond is a pentamethylene linkage.
Claim 5
Dependent Claim
18 words
The physiologically active substance-combined compound according to claim 1, wherein the physiologically active substance is human serum albumin.
Claim 6
Dependent Claim
16 words
The physiologically active substance-combined compound according to claim 1, wherein the physiologically active substance is urokinase.
Claim 7
Dependent Claim
31 words
A radioactive metallic element-labeled, physiologically active substance-combined compound comprising the physiologically active substance-combined compound according to claim 1 and a radioactive metallic element bound with said compound through a chelating bond.
Claim 8
Dependent Claim
20 words
The radioactive metallic element-labeled, physiologically active substance-combined compound according to claim 9, wherein the radioactive metallic element is 99m Tc.
Claim 9
Dependent Claim
20 words
The radioactive metallic element-labeled, physiologically active substance-combined compound according to claim 9, wherein the radioactive metallic element is 67 Ga.
Claim 10
Dependent Claim
20 words
The radioactive metallic element-labeled, physiologically active substance-combined compound according to claim 6, wherein the radioactive metallic element is 111 In.
Claim 11
Dependent Claim
43 words
A process for preparing the physiologically active substance-combined compound according to claim 1, which comprises reacting a compound of the formula: ##STR4## wherein R 1 and R 2 are each hydrogen, C 1 -C 3 alkyl or phenyl, with a physiologically active substance.
Claim 12
Dependent Claim
44 words
The process according to claim 10, wherein the physiologically active substance has a carboxyl group, and the reaction proceeds between the amino group in the compound of the formula (I) and the carboxyl group in the physiologically active substance to form a carbonamide linkage.
Claim 13
Dependent Claim
57 words
The process according to claim 10, wherein the physiologically active substance has an amino group, and the reaction proceeds between the amino group in the compound of the formula (I) and the amino group in the physiologically active substance in the presence of glutaraldehyde, followed by reduction to form a pentamethylene linkage between the said amino groups.
Claim 14
Dependent Claim
36 words
A process for preparing a radioactive metallic element-labeled, physiologically active substance-combined compound which comprises contacting the physiologically active substance-combined compound according to claim 1 with a radioactive metallic element to combine them through a chelating bond.
Claim 15
Dependent Claim
16 words
The process according to claim 13, wherein the contact is carried out in an aqueous medium.
Claim 16
Dependent Claim
19 words
The process according to claim 13, wherein the contact is carried out in the presence of a reducing agent.
Claim 17
Dependent Claim
17 words
The physiologically active substance-combined compound according to claim 1, which is in the form of a solution.
Claim 18
Dependent Claim
17 words
The physiologically active substance-combined compound according to claim 1, which is in the form of lyophilized powder.
Claim 19
Dependent Claim
18 words
The physiologically active substance-combined compound according to claim 1, wherein R 1 and R 2 are each methyl.
Claim 20
Dependent Claim
18 words
The physiologically active substance-combined compound according to claim 1, wherein R 1 and R 2 are each ethyl.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-13 | 1989-07-15 | 1990-01-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-13 | 1993-07-15 | 1994-01-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-13 | 1997-07-15 | 1998-01-14 | $7700.00 | Window Closed / Lapsed |