US4559221A
Expired / Lapsed
US
⏱️ 0.0 years remaining
P-Glyoxyloylphenylalkanoic acid bis(thiosemicarbazone) derivatives, and their production and use
Assignee: Nihon Medi Physics Co Ltd
•
Filing: 1983-10-07
•
Granted: 1985-12-17
•
Expires: 2003-10-07
Abstract
Abstract A radioactive diagnostic agent which comprises a physiologically active substance and a radioactive metallic element combined with a compound of the formula: <IMAGE> (I) wherein R is a hydrogen atom or a C1-C3 alkyl group and n is an integer of 0 to 4. The agent is characteristic in having a high stability even after being administered into a human body and showing the substantially the same behavior as the physiologically active substance itself in a human body.
Inventors
- 👤 Yasushi Arano
- 👤 Yasuhiro Magata
- 👤 Akira Yokoyama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 20:09
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K2123/00
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
29 words
A compound of the formula: ##STR4## wherein R is a hydrogen atom or a C 1 -C 3 alkyl group and n is an integer of 0 to 4.
Claim 2
Dependent Claim
29 words
A compound of the formula: ##STR4## wherein R is a hydrogen atom or a C 1 -C 3 alkyl group and n is an integer of 0 to 4.
Claim 3
Dependent Claim
10 words
The compound according to claim 1, wherein R is methyl.
Claim 4
Dependent Claim
10 words
The compound according to claim 2, wherein n is 1.
Claim 5
Dependent Claim
10 words
The compound according to claim 2, wherein n is 2.
Claim 6
Dependent Claim
10 words
The compound according to claim 2, wherein n is 3.
Claim 7
Dependent Claim
10 words
The compound according to claim 2, wherein n is 4.
Claim 8
Dependent Claim
23 words
A physiologically active substance-combined compound comprising the compound according to claim 1 and a physiologically active substance bound therewith by a chemical bond.
Claim 9
Dependent Claim
17 words
The physiologically active substance-combined compound according to claim 7, wherein the chemical bond is a carbonamide linkage.
Claim 10
Dependent Claim
18 words
The physiologically active substance-combined compound according to claim 7, wherein the physiologically active substance is human serum albumin.
Claim 11
Dependent Claim
38 words
A radioactive metallic element-labeled, physiologically active substance-combined compound comprising the compound according to claim 1, a physiologically active substance bound therewith by a chemical bond and a radioactive metallic element bound with said compound through a chelating bond.
Claim 12
Dependent Claim
20 words
The radioactive metallic element-labeled, physiologically active substance-combined compound according to claim 10, wherein the radioactive metallic element is 99m Tc.
Claim 13
Dependent Claim
27 words
A process for preparing the physiologically active substance-combined compound according to claim 7, which comprises reacting the compound according to claim 1 with a physiologically active substance.
Claim 14
Dependent Claim
44 words
The process according to claim 12, wherein the physiologically active substance has an amino group, and the reaction proceeds between the carboxyl group in the compound according to claim 1 and the amino group in the physiologically active substance to form a carbonamide linkage.
Claim 15
Dependent Claim
40 words
A process for preparing the radioactive metallic element-labeled, physiologically active substance-combined compound according to claim 10, which comprises contacting the physiologically active substance-combined compound according to claim 7 with a radioactive metallic element to combine them through a chelating bond.
Claim 16
Dependent Claim
16 words
The process according to claim 14, wherein the contact is carried out in an aqueous medium.
Claim 17
Dependent Claim
19 words
The process according to claim 15, wherein the contact is carried out in the presence of a reducing agent.
Claim 18
Dependent Claim
13 words
A non-radioactive carrier comprising the physiologically active substance-combined compound according to claim 7.
Claim 19
Dependent Claim
14 words
The non-radioactive carrier according to claim 17, which is in the form of solution.
Claim 20
Dependent Claim
15 words
The non-radioactive carrier according to claim 17, which is in the form of lyophilized powder.
Claim 21
Dependent Claim
17 words
A radioactive diagnostic agent comprising the radioactive metallic element-labeled, physiologically active substance-combined compound according to claim 10.
References Cited (Backward Citations)
SU356274A1
Cited
GB966849A
Cited
US3824276A
Cited
US3382275A
Cited
US3709935A
Cited
US4287362A
Cited
US4338248A
Cited
EP0054920A1
Cited
EP0074429A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-12-16 | 1989-06-17 | 1989-12-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-16 | 1993-06-17 | 1993-12-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-16 | 1997-06-17 | 1997-12-17 | $7700.00 | Window Closed / Lapsed |