US4557862A
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Rhodamine derivatives as fluorogenic substrates for proteinases
Assignee: ILLINOIS BOARD OF TRUSTEES 506 SOUTH WRIGHT STREET URBANA IL 61801 A CORP OF, University of
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Filing: 1983-10-28
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Granted: 1985-12-10
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Expires: 2003-10-28
Abstract
Abstract The present invention relates to a new class of novel Rhodamine derivatives. These derivatives which are bisamide substitution products are nonfluorescent. Whereas the monoamide substitution products exhibit high fluorescence. Cleavage of a single specified amide bond by bond-specific proteinases will therefore convert the nonfluorescent bisamide derivative into a highly fluorescent monoamide derivative.
Inventors
- 👤 Walter F. Mangel
- 👤 Stephen Leytus
- 👤 L. Lee Melhado
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 06:43
CPC Classifications
C; C07; C07D; C07D493/00; C07D493/02; C07D493/10; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06078; C07K5/06139; C07K5/06165; C07K5/08; C07K5/0802; C07K5/0804; C07K5/0808; C09; C09B; C09B11/00; C09B11/04; C09B11/10; C09B11/24; Y; Y10; Y10S; Y10S436/00; Y10S436/80
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
40 words
A compound of the formula: ##STR7## wherein R 1 and R 2 , which are the same or different, are selected from the group consisting of amino acids, amino acid derivatives, blocked amino acids, blocked amino acid derivatives, and peptides.
Claim 2
Dependent Claim
40 words
A compound of the formula: ##STR7## wherein R 1 and R 2 , which are the same or different, are selected from the group consisting of amino acids, amino acid derivatives, blocked amino acids, blocked amino acid derivatives, and peptides.
Claim 3
Dependent Claim
20 words
A compound according to claim 1 wherein R 1 and R 2 are amino acids, blocked amino acids, or peptides.
Claim 4
Dependent Claim
14 words
A compound according to claim 1 wherein R 1 and R 2 are peptides.
Claim 5
Dependent Claim
30 words
The compounds according to claim 3 wherein R 1 and R 2 comprise a peptide in which the amino acid bound to the amino constituent of said formula is arginine.
Claim 6
Dependent Claim
14 words
A compound according to claim 1 wherein R 1 and R 2 are peptides.
Claim 7
Dependent Claim
22 words
A compound according to claim 5 wherein R 1 and R 2 are selected from the group consisting of dipeptides and tripeptides.
Claim 8
Dependent Claim
23 words
A compound according to claim 6 wherein at least one of the amino acid residue compounds comprising said dipeptide or tripeptide is arginine.
Claim 9
Dependent Claim
30 words
A compound of the formula: ##STR8## wherein R 1 is selected from the group consisting of amino acids, amino acid derivatives, blocked amino acids, blocked amino acid derivatives, and peptides.
Claim 10
Dependent Claim
30 words
A compound of the formula: ##STR8## wherein R 1 is selected from the group consisting of amino acids, amino acid derivatives, blocked amino acids, blocked amino acid derivatives, and peptides.
Claim 11
Dependent Claim
16 words
A compound according to claim 8 wherein R 1 is selected from amino acids and peptides.
Claim 12
Dependent Claim
12 words
The compound according to claim 9 wherein R 1 is a peptide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-12-09 | 1989-06-10 | 1989-12-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-09 | 1993-06-10 | 1993-12-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-09 | 1997-06-10 | 1997-12-10 | $7700.00 | Window Closed / Lapsed |