US4556678A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sustained release propranolol tablet
Assignee: Key Pharmaceuticals Inc
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Filing: 1982-06-24
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Granted: 1985-12-03
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Expires: 2002-06-24
Abstract
Abstract A method of providing a patient suffering from cardiac arrhythmia with a sustained dosage of propranolol over a prolonged period of time comprises orally administering to the patient a tablet consisting essentially of a therapeutically effective amount of propranolol to provide a sustained release thereof over a prolonged period of time which is contained in compressed granules having from about 0.1 to about 10 parts by weight hydroxypropyl methylcellulose and about one part by weight hydroxypropyl cellulose and a lubricant for the compressed granules.
Inventors
- 👤 Charles H. Hsiao
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 09:38
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2054
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
73 words
An oral sustained release dosage unit form tablet to provide a sustained release of propranolol over a prolonged period, said tablet consisting essentially of a. a therapeutically effective amount of propranolol to provide a sustained release thereof over said prolonged period contained in b. compressed granules consisting essentially of 1. from about 0.1 to about 10 parts by weight hydroxypropyl methylcellulose having a molecular weight of from about 20,000 to about 140,000; 2.
Claim 2
Dependent Claim
73 words
An oral sustained release dosage unit form tablet to provide a sustained release of propranolol over a prolonged period, said tablet consisting essentially of a. a therapeutically effective amount of propranolol to provide a sustained release thereof over said prolonged period contained in b. compressed granules consisting essentially of 1. from about 0.1 to about 10 parts by weight hydroxypropyl methylcellulose having a molecular weight of from about 20,000 to about 140,000; 2.
Claim 3
Dependent Claim
19 words
about one part by weight hydroxypropyl cellulose having a molecular weight of from about 60,000 to about 300,000; and
Claim 4
Dependent Claim
19 words
about one part by weight hydroxypropyl cellulose having a molecular weight of from about 60,000 to about 300,000; and
Claim 5
Dependent Claim
27 words
a lubricant for said granules. 2. The dosage unit form tablet of claim 1 wherein the weight ratio of hydroxypropyl cellulose to hydroxypropyl methylcellulose is about 2:1.
References Cited (Backward Citations)
US4248856A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-12-02 | 1989-06-03 | 1989-12-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-02 | 1993-06-03 | 1993-12-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-02 | 1997-06-03 | 1997-12-03 | $7700.00 | Window Closed / Lapsed |