US4555629A
Expired / Lapsed
US
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Method and apparatus for determination of sample homogeneity in scintillation counting
Assignee: Revvity Health Sciences Inc
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Filing: 1983-09-06
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Granted: 1985-11-26
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Expires: 2003-09-06
Abstract
Abstract A method for ascertaining radiochemical homogeneity in a liquid scintillation sample reliably identifies inaccurate geometries is disclosed so that meaningful activity counts can be determined. The novel method involves measuring the activity level of a set of homogeneous quench standard to obtain quench indicating parameter, or the Spectral Index of the External standard (SIE). The endpoint of each standard sample is computed allowing the formation of a table so that a calibration curve for each radionuclide of interest can be computed. The activity level of the unknown sample is then measured and the SIE determined so that an endpoint can be calculated. Finally, the theoretical endpoint obtained from a calibration curve is compared to the computed endpoint; if the computed endpoint of the sample deviates by more than 4% for tritium and 5% for higher energy radionuclides from the theoretical endpoint, the sample is considered to be nonhomogeneous or heterogeneous. An external standard-type liquid scintillation counting system is disclosed which automatically determines sample homogeneity, and it includes a microprocessor in its control system. The steps of the present invention and incorporated into the programmed steps for the microprocessor such that nonhomogeneous or heterogeneous samples are automatically identified on the readout of the system for an investigator.
Inventors
- 👤 Leroy J. Everett
- 👤 Stanley J. DeFilippis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 00:16
CPC Classifications
G; G01; G01T; G01T1/00; G01T1/16; G01T1/20; G01T1/204; G01T1/2042; G01T1/2045
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
169 words
A liquid scintillation counting system for use with a test sample containing one, or more, radioactive isotopes together with a liquid scintillator, the degeneration of an isotope distributed in a known manner over spectrum, comprising: transducer means for converting each pulse emanating from said test sample to an electrical signal proportional thereto; coincidence means connected to said transducer means for eliminating pulses which do not fall within a predetermined time differential window thus passing only those pulses which relate to a nuclear event; quantizing means connected to said coincidence means for identifying a parameter of each pulse passed by said coincidence means; processing means, including storage means, connected to said quantizing means for receiving and storing parameter data related to each nuclear event, for calculating the radionuclide endpoint, for calculating a calibration curve associated with each radioactive isotope, and for comparing the computed endpoint of a test sample with the theoretical endpoint to determine if said test sample deviates by more than a predetermined amount thereby identifying heterogeneous states.
Claim 2
Dependent Claim
169 words
A liquid scintillation counting system for use with a test sample containing one, or more, radioactive isotopes together with a liquid scintillator, the degeneration of an isotope distributed in a known manner over spectrum, comprising: transducer means for converting each pulse emanating from said test sample to an electrical signal proportional thereto; coincidence means connected to said transducer means for eliminating pulses which do not fall within a predetermined time differential window thus passing only those pulses which relate to a nuclear event; quantizing means connected to said coincidence means for identifying a parameter of each pulse passed by said coincidence means; processing means, including storage means, connected to said quantizing means for receiving and storing parameter data related to each nuclear event, for calculating the radionuclide endpoint, for calculating a calibration curve associated with each radioactive isotope, and for comparing the computed endpoint of a test sample with the theoretical endpoint to determine if said test sample deviates by more than a predetermined amount thereby identifying heterogeneous states.
Claim 3
Independent Claim
88 words
A method for ascertaining radiochemical homogeneity of a liquid scintillation test sample, comprising the steps of: (a) calculating a radionuclide calibration equation for each radionuclide of interest from a quench indicating parameter, and calculating a radionuclide endpoint for each radionuclide of interest; (b) comparing a theoretical endpoint associated with the radionuclide calibration equation with the computed endpoint associated with said test sample to determine if the deviation is greater than approximately 4% for tritium and 5% for higher energy radionuclides thus indicating that the test sample is heterogeneous.
Claim 4
Independent Claim
88 words
A method for ascertaining radiochemical homogeneity of a liquid scintillation test sample, comprising the steps of: (a) calculating a radionuclide calibration equation for each radionuclide of interest from a quench indicating parameter, and calculating a radionuclide endpoint for each radionuclide of interest; (b) comparing a theoretical endpoint associated with the radionuclide calibration equation with the computed endpoint associated with said test sample to determine if the deviation is greater than approximately 4% for tritium and 5% for higher energy radionuclides thus indicating that the test sample is heterogeneous.
Claim 5
Dependent Claim
51 words
A method as set forth in claim 2, wherein step (a) involves the step of measuring the Spectral Index of External Standards (SIE) of a set of appropriate quench standards for each radionuclide of interest and calculating a theoretical endpoint for each radioactive isotope associated with a set of standard samples.
Claim 6
Dependent Claim
38 words
The method according to claim 3, further characterized by the steps prior to step (b) of determining the activity level of said test sample to obtain the SIE parameter and calculating the endpoints for each radionuclide of interest.
Claim 7
Independent Claim
130 words
A method for ascertaining radiochemical homogeneity of a liquid scintillation test sample, comprising the steps of: measuring a quench indicating parameter, of a set of appropriate quench standards for each radionuclide of interest; calculating a theoretical endpoint for each radioactive isotope in said set of appropriate quench standards; calculating a radionuclide calibration curve for each radionuclide of interest from the quench indicating parameter data and measured endpoints; measuring the activity level of a test sample containing unknown radionuclides to obtain a quench indicating parameter calibration curve and calculating the endpoint of the radioactive isotopes in said test sample; and comparing the theoretical endpoint obtained from the calibration curve with the computed endpoint to determine if the deviation is greater than a predetermined amount thus indicating the test sample is heterogeneous.
Claim 8
Independent Claim
130 words
A method for ascertaining radiochemical homogeneity of a liquid scintillation test sample, comprising the steps of: measuring a quench indicating parameter, of a set of appropriate quench standards for each radionuclide of interest; calculating a theoretical endpoint for each radioactive isotope in said set of appropriate quench standards; calculating a radionuclide calibration curve for each radionuclide of interest from the quench indicating parameter data and measured endpoints; measuring the activity level of a test sample containing unknown radionuclides to obtain a quench indicating parameter calibration curve and calculating the endpoint of the radioactive isotopes in said test sample; and comparing the theoretical endpoint obtained from the calibration curve with the computed endpoint to determine if the deviation is greater than a predetermined amount thus indicating the test sample is heterogeneous.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-11-25 | 1989-05-27 | 1989-11-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-11-25 | 1993-05-27 | 1993-11-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-11-25 | 1997-05-27 | 1997-11-26 | $7700.00 | Window Closed / Lapsed |