7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment of thrombolytic disease

Claim 1

A compound having the structural formula ##STR23## and including all stereoisomers thereof, wherein A is --CH═CH-- or --(CH 2 ) 2 --; p is 0 to 4; m is 0 to 8; n is 1 to 4; n' is 0, 1 or 2; q is 1 to 4; R is hydrogen, lower alkyl or alkali metal; X is S, O, or NH; and R 1 is lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, wherein the term lower alkyl or alkyl by itself or as part of another group contains 1 to 12 carbons and is unsubstituted or substituted with halo, trifluoromethyl, alkoxy, haloaryl, cycloalkyl or alkylcycloalkyl; the term aryl by itself or as part of another group contains 6 to 10 carbons and is unsubstituted or substituted with lower alkyl, halogen or lower alkoxy; the term cycloalkyl by itself or as part of another group contains 3 to 12 carbons and is unsubstituted or substituted with 1 or 2 halogens, 1 or 2 lower alkyl groups and/or 1 or 2 lower alkoxy groups; and (CH 2 ) p , (CH 2 ) m , (CH 2 ) n and (CH 2 ) q can be substituted by one or more alkyl groups.