US4555504A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inclusion complex of β-cyclodextrin and digoxin
Assignee: SmithKline Beecham Corp
•
Filing: 1984-03-12
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Granted: 1985-11-26
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Expires: 2004-03-12
Abstract
Abstract Inclusion complexes of cyclodextrins, particularly β-cyclodextrin, and cardiac glycosides, particularly digoxin, are disclosed. The complexes have high aqueous solubility and are useful in the preparation of pharmaceutical formulations containing cardiac glycosides for use in therapy.
Inventors
- 👤 Harry P. Jones
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 02:07
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61K31/7042; A61K31/7048; A61K47/00; A61K47/50; A61K47/69; A61K47/6949; A61K47/6951; A61P; A61P9/00; A61P9/04; B; B82; B82Y; B82Y5/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
26 words
A pharmaceutical composition comprising a nontoxic, effective cardiac dysfunction treatment amount of an inclusion complex of β-cyclodextrin and digoxin together with a pharmaceutically acceptable carrier therefor.
Claim 2
Dependent Claim
26 words
A pharmaceutical composition comprising a nontoxic, effective cardiac dysfunction treatment amount of an inclusion complex of β-cyclodextrin and digoxin together with a pharmaceutically acceptable carrier therefor.
Claim 3
Independent Claim
36 words
A method for the treatment of cardiac dysfunction in a mammal in need thereof which comprises administration to said mammal of a nontoxic, effective cardiac dysfunction treatment amount of an inclusion complex of β-cyclodextrin and digoxin.
Claim 4
Independent Claim
36 words
A method for the treatment of cardiac dysfunction in a mammal in need thereof which comprises administration to said mammal of a nontoxic, effective cardiac dysfunction treatment amount of an inclusion complex of β-cyclodextrin and digoxin.
Claim 5
Dependent Claim
12 words
The method of claim 2 wherein the mammal is a human being.
Claim 6
Dependent Claim
6 words
Inclusion complexes of β-cyclodextrin and digoxin.
Claim 7
Dependent Claim
6 words
Inclusion complexes of β-cyclodextrin and digoxin.
Claim 8
Dependent Claim
22 words
A complex according to claim 4 wherein the molar ratio of β-cyclodextrin to digoxin is in the range from 10:1 to 1:10.
Claim 9
Dependent Claim
22 words
A complex according to claim 4 wherein the molar ratio of β-cyclodextrin to digoxin is in the range from 2:1 to 5:1.
Claim 10
Dependent Claim
21 words
A complex according to claim 4 wherein the digoxin is present in an amount of from 0.01% to 1% by weight.
References Cited (Backward Citations)
US3541077A
Cited
US4083969A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-11-25 | 1989-05-27 | 1989-11-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-11-25 | 1993-05-27 | 1993-11-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-11-25 | 1997-05-27 | 1997-11-26 | $7700.00 | Window Closed / Lapsed |