US4552842A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for producing rebeccamycin
Assignee: Bristol Myers Co
•
Filing: 1984-04-13
•
Granted: 1985-11-12
•
Expires: 2004-04-13
Abstract
Abstract A novel antitumor agent designated herein as rebeccamycin is produced by fermentation of Nocardia aerocolonigenes (ATCC 39243). Rebeccamycin and its 5'-N-methyl and 5',2'',3'',6''-tetraacetate derivatives exhibit activity against experimental animal tumor systems.
Inventors
- 👤 Donald E. Nettleton, Jr.
- 👤 James A. Bush
- 👤 William T. Bradner
- 👤 Terrence W. Doyle
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:43
CPC Classifications
C; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/044; C12P; C12P19/00; C12P19/26; C12P19/28; C12R; C12R2001/00; C12R2001/01; C12R2001/365; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/872
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
52 words
A process for producing rebeccamycin having the formula ##STR4## which comprises cultivating Nocardia aerocolonigenes ATCC 39243 or a rebeccamycin-producing mutant thereof in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen under submerged aerobic conditions until a substantial amount of rebeccamycin is produced by said organism in said culture medium.
Claim 2
Dependent Claim
52 words
A process for producing rebeccamycin having the formula ##STR4## which comprises cultivating Nocardia aerocolonigenes ATCC 39243 or a rebeccamycin-producing mutant thereof in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen under submerged aerobic conditions until a substantial amount of rebeccamycin is produced by said organism in said culture medium.
Claim 3
Dependent Claim
15 words
The process according to claim 1 wherein the rebeccamycin is recovered from the culture medium.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-11-11 | 1989-05-13 | 1989-11-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-11-11 | 1993-05-13 | 1993-11-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-11-11 | 1997-05-13 | 1997-11-12 | $7700.00 | Window Closed / Lapsed |