US4548819A
Expired / Lapsed
US
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Derivatives of 9-(2-hydroxyethoxymethyl) guanine
Assignee: Wellcome Foundation Ltd
•
Filing: 1983-06-23
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Granted: 1985-10-22
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Expires: 2003-06-23
Abstract
Abstract Compounds of the general formula ##STR1## (wherein X represents an oxygen or sulphur atom, R 1 represents a hydroxy or amino group, R 2 represents a hydrogen atom or a group of formula --CH 2 OR 3 a and R 3 and R 3 a which may be the same or different, each represents an amino acid acyl radical) and physiologically acceptable salts thereof are useful for the treatment of viral infections and have been found to have a surprisingly high water-solubility which renders them of value in the formulation of aqueous pharmaceutical preparations. Processes for preparing the compounds are described.
Inventors
- 👤 Erik D. A. de Clercq
- 👤 Hubert J. H. E. Vander Haeghe
- 👤 Roger H. C. Busson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 10:33
CPC Classifications
C; C07; C07D; C07D473/00; A; A61; A61P; A61P31/00; A61P31/12
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
1 words
9-(2-0-Glycyloxyethoxymethyl)guanine.
Claim 2
Dependent Claim
1 words
9-(2-0-Glycyloxyethoxymethyl)guanine.
Claim 3
Dependent Claim
1 words
9-(2-0-α-Alanyloxyethoxymethyl)guanine.
Claim 4
Dependent Claim
1 words
9-(2-0-α-Alanyloxyethoxymethyl)guanine.
Claim 5
Dependent Claim
1 words
9-(2-0-β-Alanyloxyethoxymethyl)guanine.
Claim 6
Dependent Claim
1 words
9-(2-0-β-Alanyloxyethoxymethyl)guanine.
Claim 7
Dependent Claim
6 words
A pharmacologically acceptable salt of 9-(2-0-Glycyloxyethoxymethyl)guanine.
Claim 8
Dependent Claim
6 words
A pharmacologically acceptable salt of 9-(2-0-Glycyloxyethoxymethyl)guanine.
Claim 9
Dependent Claim
6 words
The hydrochloride salt of claim 4.
Claim 10
Dependent Claim
26 words
The method of treating a keratitis infection in a mammal which comprises administering the compound or salt of claim 1, 4 or 5 to said mammal.
Claim 11
Dependent Claim
26 words
The method of treating an iritis infection in a mammal which comprises administering the compound or salt of claim 1, 4 or 5 to said mammal.
Claim 12
Dependent Claim
9 words
A pharmacologically acceptable salt of claim 2 or 3.
References Cited (Backward Citations)
US4323573A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-10-21 | 1989-04-22 | 1989-10-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-10-21 | 1993-04-22 | 1993-10-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-10-21 | 1997-04-22 | 1997-10-22 | $7700.00 | Window Closed / Lapsed |