US4546182A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3,8-Dialkylxanthines
Assignee: Draco AB
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Filing: 1983-08-16
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Granted: 1985-10-08
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Expires: 2003-08-16
Abstract
Abstract The invention refers to compounds having activity against chronic obstructive airway disease or cardiovascular disease, characterized by the formula ##STR1## wherein R 1 is ethyl, n-propyl, n-butyl, isobutyl, n-pentyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, cyclopropyl, cyclobutyl, cyclopentyl or cyclohexylmethyl, and R 2 is methyl, ethyl, n-propyl, isopropyl, cyclopropyl, n-butyl, isobutyl, tert. butyl, or cyclobutyl provided that R 1 is ethyl when R 2 is methyl, or a physiologically acceptable salt thereof. The invention also refers to processes for the preparation of these compounds, a pharmaceutical preparation containing one of the compounds and a method for the treatment of chronic obstructive airway disease and cardiovascular disease.
Inventors
- 👤 Per G. Kjellin
- 👤 Carl G. A. Persson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 13:18
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/52; C07D239/54; C07D239/545; A; A61; A61P; A61P11/00; A61P11/08; A61P9/00; A61P9/04; C07D473/00; C07D473/02; C07D473/04; C07D473/06
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
150 words
A compound of the formula ##STR11## or a physiologically acceptable salt thereof, in which formula R 1 is ethyl, n-propyl, n-butyl, isobutyl, n-pentyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, cyclopropyl, cyclobutyl, or cyclopentyl and R 2 is methyl, ethyl, n-propyl, isopropyl, cyclopropyl, n-butyl, isobutyl, tert. butyl or cyclobutyl provided that R 1 is ethyl when R 2 is methyl; when R 2 is ethyl, R 1 is ethyl, n-propyl, n-butyl, isobutyl, n-pentyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, cyclopropyl, cyclobutyl, or cyclopentyl; when R 2 is n-propyl, R 1 is ethyl, n-propyl, or cyclopropyl; when R 2 is isopropyl, R 1 is ethyl or n-propyl; when R 2 is cyclopropyl, R 1 is n-propyl; when R 2 is n-butyl, R 1 is ethyl or n-propyl; when R 2 is isobutyl, R 1 is ethyl or n-propyl; when R 2 is tert. butyl, R 1 is n-propyl; and when R 2 is cyclobutyl, R 1 is n-propyl.
Claim 2
Dependent Claim
150 words
A compound of the formula ##STR11## or a physiologically acceptable salt thereof, in which formula R 1 is ethyl, n-propyl, n-butyl, isobutyl, n-pentyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, cyclopropyl, cyclobutyl, or cyclopentyl and R 2 is methyl, ethyl, n-propyl, isopropyl, cyclopropyl, n-butyl, isobutyl, tert. butyl or cyclobutyl provided that R 1 is ethyl when R 2 is methyl; when R 2 is ethyl, R 1 is ethyl, n-propyl, n-butyl, isobutyl, n-pentyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, cyclopropyl, cyclobutyl, or cyclopentyl; when R 2 is n-propyl, R 1 is ethyl, n-propyl, or cyclopropyl; when R 2 is isopropyl, R 1 is ethyl or n-propyl; when R 2 is cyclopropyl, R 1 is n-propyl; when R 2 is n-butyl, R 1 is ethyl or n-propyl; when R 2 is isobutyl, R 1 is ethyl or n-propyl; when R 2 is tert. butyl, R 1 is n-propyl; and when R 2 is cyclobutyl, R 1 is n-propyl.
Claim 3
Dependent Claim
16 words
A compound according to claim 1 with the formula ##STR12## or a physiologically acceptable salt thereof.
Claim 4
Dependent Claim
16 words
A compound according to claim 1 with the formula ##STR13## or a physiologically acceptable salt thereof.
Claim 5
Dependent Claim
16 words
A compound according to claim 1 with the formula ##STR14## or a physiologically acceptable salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-10-07 | 1989-04-08 | 1989-10-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-10-07 | 1993-04-08 | 1993-10-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-10-07 | 1997-04-08 | 1997-10-08 | $7700.00 | Window Closed / Lapsed |