US4544765A
Expired / Lapsed
US
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Chloramphenicol derivatives
Assignee: Syva Co
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Filing: 1984-11-30
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Granted: 1985-10-01
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Expires: 2004-11-30
Abstract
Abstract Chloramphenicol derivatives are provided for use in the preparing of antigen conjugates for the production of antibodies specifically for chloramphenicol. Specifically, the aryl amino group is derivatized to introduce a non-oxocarbonyl group which is used for amide formation with an antigen. The conjugate is then injected into a vertebrate for production of antisera which is isolated in conventional ways and find particular use in competitive protein binding assays.
Inventors
- 👤 Pyare Khanna
- 👤 Evan S. Snyder
- 👤 Prithipal Singh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 23:49
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/94; G01N33/9446
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
118 words
A compound of the formula: ##STR4## wherein: R is an aliphatic linking group of up to 12 atoms other than hydrogen having a chain of from 2 to 8 atoms comprised of carbon, nitrogen, and chalcogen of atomic no. 8 to 16; Z is hydrogen, hydroxyl, alkoxyl of from 1 to 6 carbon atoms, a group forming an activated ester capable of amide formation in an aqueous medium, or a poly(amino acid) which is antigenic or an enzyme; m is 0 or 1, when Z is a poly(amino acid) and is otherwise 1; and n is 1 when Z is other than a poly(amino acid) and is otherwise 1 to the molecular weight of Z divided by 1000.
Claim 2
Dependent Claim
118 words
A compound of the formula: ##STR4## wherein: R is an aliphatic linking group of up to 12 atoms other than hydrogen having a chain of from 2 to 8 atoms comprised of carbon, nitrogen, and chalcogen of atomic no. 8 to 16; Z is hydrogen, hydroxyl, alkoxyl of from 1 to 6 carbon atoms, a group forming an activated ester capable of amide formation in an aqueous medium, or a poly(amino acid) which is antigenic or an enzyme; m is 0 or 1, when Z is a poly(amino acid) and is otherwise 1; and n is 1 when Z is other than a poly(amino acid) and is otherwise 1 to the molecular weight of Z divided by 1000.
Claim 3
Dependent Claim
18 words
A compound according to claim 1, wherein R is a 1-oxopolymethylene of from 3 to 5 carbon atoms.
Claim 4
Dependent Claim
13 words
A compound according to claim 2, wherein R is of 4 carbon atoms.
Claim 5
Dependent Claim
68 words
A compound of the formula: ##STR5## wherein: R is a saturated aliphatic linking group of from 2 to 8 carbon atoms having from 0 to 1 oxo-carbonyl group at the terminus bonded to nitrogen; Y 2 is hydrogen, hydroxyl, alkoxyl from 1 to 6 carbon atoms, or a group forming an activated ester capable of amide formation in an aqueous medium; m is 1; n 2 is 1.
Claim 6
Dependent Claim
68 words
A compound of the formula: ##STR5## wherein: R is a saturated aliphatic linking group of from 2 to 8 carbon atoms having from 0 to 1 oxo-carbonyl group at the terminus bonded to nitrogen; Y 2 is hydrogen, hydroxyl, alkoxyl from 1 to 6 carbon atoms, or a group forming an activated ester capable of amide formation in an aqueous medium; m is 1; n 2 is 1.
Claim 7
Dependent Claim
19 words
A compound according to claim 4, wherein R is α-oxopentamethylene, N 2 is 1, and y 2 is OH.
References Cited (Backward Citations)
US2483884A
Cited
US2483885A
Cited
US2538764A
Cited
US2686788A
Cited
US3592949A
Cited
US4214001A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-30 | 1989-04-01 | 1989-10-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-30 | 1993-04-01 | 1993-10-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-30 | 1997-04-01 | 1997-10-01 | $7700.00 | Window Closed / Lapsed |