US4544752A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels
Assignee: Eli Lilly and Co
•
Filing: 1983-06-06
•
Granted: 1985-10-01
•
Expires: 2003-06-06
Abstract
Abstract 3-Phenyl (or meta or para-substituted phenyl)-4-permissibly substituted-5-isothiazolecarboxylic acids, salts, esters and simple amides, used to lower uric acid levels in mammals.
Inventors
- 👤 James R. Beck
- 👤 Robert P. Gajewski
- 👤 Ronald E. Hackler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 11:47
CPC Classifications
C; C07; C07D; C07D275/00; C07D275/02; C07D275/03; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/54; C07D213/57; C07D333/00; C07D333/02; C07D333/04; C07D333/06; C07D333/24
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
45 words
A compound of the formula ##STR11## wherein X is NH 2 , OH, hal, H or NHalk; and R is OH or OM; wherein hal is Cl, Br, I or F; alk is (C 1 -C 3 ) alkyl and M is a non-toxic cation.
Claim 2
Dependent Claim
45 words
A compound of the formula ##STR11## wherein X is NH 2 , OH, hal, H or NHalk; and R is OH or OM; wherein hal is Cl, Br, I or F; alk is (C 1 -C 3 ) alkyl and M is a non-toxic cation.
Claim 3
Dependent Claim
14 words
A compound of the group 3-(3-fluoro-4-methoxyphenyl)-4-amino-5-isothiazolecarboxylic acid, 3-(4-isopropoxyphenyl)-4-amino-5-isothiazolecarboxylic acid, 3-(4-anisyl)-4-chloro-5-isothiazolecarboxylic acid and 3-(3-chlorophenyl)-4-chloro-5-isothiazolecarboxylic acid.
Claim 4
Dependent Claim
14 words
A compound of the group 3-(3-fluoro-4-methoxyphenyl)-4-amino-5-isothiazolecarboxylic acid, 3-(4-isopropoxyphenyl)-4-amino-5-isothiazolecarboxylic acid, 3-(4-anisyl)-4-chloro-5-isothiazolecarboxylic acid and 3-(3-chlorophenyl)-4-chloro-5-isothiazolecarboxylic acid.
Claim 5
Dependent Claim
45 words
A compound of the formula ##STR12## wherein X is NH 2 , H, OH, hal or Nalk; and R is NH 2 , NHalk or N(alk) 2 , wherein hal is F, Cl, Br or I and alk is (C 1 -C 3 ) alkyl.
Claim 6
Dependent Claim
45 words
A compound of the formula ##STR12## wherein X is NH 2 , H, OH, hal or Nalk; and R is NH 2 , NHalk or N(alk) 2 , wherein hal is F, Cl, Br or I and alk is (C 1 -C 3 ) alkyl.
Claim 7
Dependent Claim
11 words
A compound according to claim 1, said compound being 3-(3-trifluoromethylphenyl)-4-amino-5-isothiazolecarboxylic acid.
Claim 8
Dependent Claim
11 words
A compound according to claim 1, said compound being 3-(3-trifluoromethylphenyl)-4-hydroxy-5-isothiazolecarboxylic acid.
Claim 9
Dependent Claim
11 words
A compound according to claim 1, said compound being 3-(3-trifluoromethylphenyl)-4-chloro-5-isothiazolecarboxylic acid.
Claim 10
Dependent Claim
11 words
A compound according to claim 1, said compound being 3-(3-trifluoromethylphenyl)-4-bromo-5-isothiazolecarboxylic acid.
Claim 11
Dependent Claim
11 words
A compound according to claim 1, said compound being 3-(3-trifluoromethylphenyl)-4-fluoro-5-isothiazolecarboxylic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-30 | 1989-04-01 | 1989-10-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-30 | 1993-04-01 | 1993-10-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-30 | 1997-04-01 | 1997-10-01 | $7700.00 | Window Closed / Lapsed |