US4542015A
Expired / Lapsed
US
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Dialysis apparatus and process for controlling the phosphate level of blood
Assignee: COBE NEPHROSS BV
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Filing: 1982-08-19
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Granted: 1985-09-17
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Expires: 2002-08-19
Abstract
Abstract An apparatus for purifying blood has a blood compartment and a clearance compartment separated by a semi-permeable membrane. The apparatus includes a device containing a cation exchange resin charged with metal ions whose phosphates are insoluble in water. Metal salts of iron, aluminum, zirconium, lanthanum, thorium and tin are deposited on a cation exchange material and the charged cation exchange resin is contacted with dialysis liquid. The process of treating blood with the dialysis liquid is also contemplated.
Inventors
- 👤 Robert Smakman
- 👤 Gerrit H. van den Berg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 06:47
CPC Classifications
A; A61; A61K; A61K33/00; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/585; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/1694; A61M1/1696; A61M1/36; A61M1/3679; B; B01; B01J; B01J39/00; B01J39/04; B01J39/05; B01J39/07; B01J39/08; B01J39/16; B01J39/18; B01J39/20; B01J41/00; B01J41/04; B01J41/05
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
57 words
In a method for the preparation of a cation exchanger charged with metal ions adapted for controlling the phosphate level in blood by oral administration, the steps which comprise charging a cation exchanger with from 10% to 100% alkali metal ions before or after it is charged with ions of iron (III), tin, lanthanum, aluminum or zirconium.
Claim 2
Dependent Claim
57 words
In a method for the preparation of a cation exchanger charged with metal ions adapted for controlling the phosphate level in blood by oral administration, the steps which comprise charging a cation exchanger with from 10% to 100% alkali metal ions before or after it is charged with ions of iron (III), tin, lanthanum, aluminum or zirconium.
Claim 3
Dependent Claim
27 words
The method of claim 1, wherein the said alkali metal ions are sodium and the said metal ions which react with phosphate ions are iron III ions.
Claim 4
Dependent Claim
28 words
A phosphate sorbent for oral administration capable of controlling the phosphate level in blood comprising an organic cation exchanger charged with ferric ions in a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
28 words
A phosphate sorbent for oral administration capable of controlling the phosphate level in blood comprising an organic cation exchanger charged with ferric ions in a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
14 words
A phosphate sorbent according to claim 3 comprising a weakly acid organic cation exchanger.
Claim 7
Dependent Claim
20 words
The phosphate sorbent of claim 4 wherein the cation exchanger contains carboxylic acid groups, phosphonic acid groups or amidoxime groups.
Claim 8
Dependent Claim
17 words
The phosphate sorbent of claim 5 wherein the cation exchanger contains aminocarboxylic acid or iminodicarboxylic acid groups.
Claim 9
Dependent Claim
17 words
The phosphate sorbent of claim 5 wherein the cation exchanger contains aminoacetic acid or iminodiacetic acid groups.
Claim 10
Dependent Claim
16 words
The phosphate sorbent of claim 3 wherein the cation exchanger is a strongly acid cation exchanger.
Claim 11
Dependent Claim
16 words
The phosphate sorbent of claim 3 wherein the cation exchanger has a high degree of cross-linking.
Claim 12
Dependent Claim
14 words
The phosphate sorbent of claim 8 wherein the cation exchanger contains sulphonic acid groups.
Claim 13
Dependent Claim
32 words
The phosphate sorbent of claim 3 wherein the cation exchanger has a matrix comprising a polymer or a polycondensation product of an aromatic compound, an acryl, a methacryl or a vinyl compound.
Claim 14
Dependent Claim
14 words
The phosphate sorbent of claim 3 wherein the cation exchanger has a macroporous matrix.
Claim 15
Dependent Claim
14 words
The phosphate sorbent of claim 3 wherein the cation exchanger contains alkali metal ions.
Claim 16
Dependent Claim
14 words
The phosphate sorbent of claim 13 wherein the alkali metal ions are sodium ions.
Claim 17
Dependent Claim
20 words
The phosphate sorbent of claim 13 wherein the cation exchanger contains calcium or magnesium ions and the alkali metal ions.
Claim 18
Dependent Claim
19 words
The phosphate sorbent of claim 3 wherein the pharmaceutically acceptable carrier is a capsule having a cationic semipermeable wall.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1988-09-16 | 1989-03-18 | 1989-09-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-16 | 1993-03-18 | 1993-09-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-16 | 1997-03-18 | 1997-09-17 | $7700.00 | Window Closed / Lapsed |