Patent US1906691A successfully refreshed from Google Patents.
US4540801A
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5 Fluoro PGI compounds
Assignee: GD Searle LLC
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Filing: 1983-07-13
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Granted: 1985-09-10
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Expires: 2003-07-13
Abstract
Abstract The present invention relates to 5-fluoro-PGI 2 derivatives of Formula I. These compounds are useful for the treatment of platelet dysfunction. Also disclosed is the process for preparing them and the appropriate intermediates.
Inventors
- 👤 Leonard N. Nysted
- 👤 Raphael Pappo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:49
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/93; C07D307/935; C07D307/937
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
147 words
A compound of formula I wherein R 1 is: (a) OR 2 ; (b) NR 3 R 4 (c) ##STR10## or (d) ##STR11## wherein R 2 is: (a) Na, K, or 1/2 Ca; (b) hydroxyalkyl of 1 to 6 C atoms; (c) hydrogen; or (d) alkyl of 1 to 6 carbon atoms wherein R 3 is: (a) hydrogen; or (b) alkyl of 1 to 6 carbon atoms, inclusive; wherein R 4 is: (a) hydrogen; or (b) alkyl of 1 to 6 carbon atoms, inclusive; wherein n is an integer from 4 to 5; wherein m and q are integers and taken together equal 4 to 5 wherein Y is: (a) O (b) NH wherein X is: (a) ##STR12## or (b) ##STR13## wherein R 5 is alkoxy from 1 to 6 carbon atoms and the individual isomers either alone or in combination; and the pharmacologically acceptable salts thereof.
Claim 2
Dependent Claim
147 words
A compound of formula I wherein R 1 is: (a) OR 2 ; (b) NR 3 R 4 (c) ##STR10## or (d) ##STR11## wherein R 2 is: (a) Na, K, or 1/2 Ca; (b) hydroxyalkyl of 1 to 6 C atoms; (c) hydrogen; or (d) alkyl of 1 to 6 carbon atoms wherein R 3 is: (a) hydrogen; or (b) alkyl of 1 to 6 carbon atoms, inclusive; wherein R 4 is: (a) hydrogen; or (b) alkyl of 1 to 6 carbon atoms, inclusive; wherein n is an integer from 4 to 5; wherein m and q are integers and taken together equal 4 to 5 wherein Y is: (a) O (b) NH wherein X is: (a) ##STR12## or (b) ##STR13## wherein R 5 is alkoxy from 1 to 6 carbon atoms and the individual isomers either alone or in combination; and the pharmacologically acceptable salts thereof.
Claim 3
Dependent Claim
10 words
A compound according to claim 1 wherein X is ##STR14##
Claim 4
Dependent Claim
22 words
5-fluorohexahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-2-methoxy-2H-cyclopenta[b]furan-2-pentanoic acid, and the individual isomers either alone or in combination, and the pharmacologically acceptable salts thereof, compounds according to claim 2.
Claim 5
Dependent Claim
21 words
5-fluorohexahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-2-methoxy-2H-cyclopenta[b]furan-2-pentanamide and the individual isomers either alone or in combination, and the pharmacologically acceptable salts thereof, compounds according to claim 2.
Claim 6
Dependent Claim
10 words
A compound according to claim 1 wherein X is ##STR15##
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-09 | 1989-03-11 | 1989-09-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-09 | 1993-03-11 | 1993-09-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-09 | 1997-03-11 | 1997-09-10 | $7700.00 | Window Closed / Lapsed |