Patent US5080439A successfully refreshed from Google Patents.
US4540697A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aminopropanol derivatives of 2-hydroxy-β-phenyl-propiophenones, pharmaceutical compositions and use
Assignee: BASF SE
•
Filing: 1984-05-23
•
Granted: 1985-09-10
•
Expires: 2004-05-23
Abstract
Abstract Novel aminopropanol derivatives of 2-hydroxy-β-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
Inventors
- 👤 Albrecht Franke
- 👤 Josef Muller
- 👤 Helmut Lietz
- 👤 Walter-Wielant Wiersdorff
- 👤 Hans-Gunther Hege
- 👤 Claus D. Muller
- 👤 Josef Gries
- 👤 Dieter Lenke
- 👤 Gerda von Philipsborn
- 👤 Manfred Raschack
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 12:45
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; C07C; C07C45/00; C07C45/61; C07C45/62; C07C45/67; C07C45/68; C07C45/70; C07C45/71; C07C45/72; C07C45/73; C07C45/74; C07C49/00; C07C49/76; C07C49/82; C07C49/83; C07C49/835; C07C49/84; C07D303/00; C07D303/02; C07D303/12; C07D303/18; C07D303/20; C07D303/22; C07D303/24
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
55 words
An aminopropanol derivative of the formula ##STR6## wherein R 1 is n-propyl, isopropyl, cyclopropyl, 3-methoxyisopropyl or n-butyl, R 2 is hydrogen or together with R 1 and the nitrogen atom linking R 1 and R 2 form 4-methyl-piperazin-1-yl and R 5 and R 6 are methyl or ethyl or a physiologically acceptable acid addition thereof.
Claim 2
Dependent Claim
55 words
An aminopropanol derivative of the formula ##STR6## wherein R 1 is n-propyl, isopropyl, cyclopropyl, 3-methoxyisopropyl or n-butyl, R 2 is hydrogen or together with R 1 and the nitrogen atom linking R 1 and R 2 form 4-methyl-piperazin-1-yl and R 5 and R 6 are methyl or ethyl or a physiologically acceptable acid addition thereof.
Claim 3
Dependent Claim
19 words
An aminopropanol derivative as claimed in claim 1, which is 2-(2'-Hydroxy-3'-isopropylaminopropoxy)-β-(4-dimethylaminophenyl)propiophenone or a physiologically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
19 words
An aminopropanol derivative as claimed in claim 1, which is 2-(2'-Hydroxy-3'-n-propylaminopropoxy-β-(4-dimethylaminophenyl)-propiophenone or a physiologically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
19 words
An aminopropanol derivative as claimed in claim 1, which is 2-(2'-Hydroxy-3'-cyclopropylaminopropoxy)-β-(4-dimethylaminophenyl)propiophenone or a physiologically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
19 words
An aminopropanol derivative as claimed in claim 1, which is 2-[2'-Hydroxy-3'-(3-methoxy-prop-2-yl-amino)-propoxy]-β-(4-dimethylaminophenyl)-propiophenone or a physiologically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
19 words
An aminopropanol derivative as claimed in claim 1, which is 2-(2'-Hydroxy-3'-n-propylaminopropoxy]-β-(4-diethylaminophenyl)-propiophenone or a physiologically acceptable acid addition salt thereof.
Claim 8
Dependent Claim
9 words
2-(2'-Hydroxy-3'-n-butylaminopropoxy)-β-(4-dimethylaminophenyl)-propiophenone or a physiologically acceptable acid addition salt thereof.
Claim 9
Dependent Claim
9 words
2-(2'-Hydroxy-3'-n-butylaminopropoxy)-β-(4-dimethylaminophenyl)-propiophenone or a physiologically acceptable acid addition salt thereof.
Claim 10
Dependent Claim
9 words
2-[2'-Hydroxy-3'-(4-methyl-piperazin-1-yl)-propoxy]-5-methyl-β-(4-dimethylaminophenyl)-propiophenone or a physiologically acceptable acid addition salt thereof.
Claim 11
Dependent Claim
9 words
2-[2'-Hydroxy-3'-(4-methyl-piperazin-1-yl)-propoxy]-5-methyl-β-(4-dimethylaminophenyl)-propiophenone or a physiologically acceptable acid addition salt thereof.
Claim 12
Dependent Claim
27 words
A therapeutic composition for treating cardiac arrhythmias and coronary insufficiency comprising a pharmaceutical excipient and an effective amount of an aminopropanol derivative as defined in claim 1.
Claim 13
Dependent Claim
32 words
The method of treating cardiac arrhythmias and coronary insufficiency in a patient suffering therefrom, which comprises administering to the patient an effective amount of an aminopropanol derivative as defined in claim 1.
References Cited (Backward Citations)
US3812129A
Cited
GB1307455A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-09 | 1989-03-11 | 1989-09-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-09 | 1993-03-11 | 1993-09-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-09 | 1997-03-11 | 1997-09-10 | $7700.00 | Window Closed / Lapsed |