US4537858A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Plastatin
Assignee: ER Squibb and Sons LLC
•
Filing: 1984-06-22
•
Granted: 1985-08-27
•
Expires: 2004-06-22
Abstract
Abstract Plastatin, an inhibitor of the enzyme phospholipase A 2 , can be prepared by cultivating Penicillium chermesinum under submerged aerobic conditions.
Inventors
- 👤 Joseph O'Sullivan
- 👤 Carol A. Aklonis
- 👤 Pushpa Singh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 06:01
CPC Classifications
C; C12; C12N; C12N1/00; C12N1/14; C12N1/145; C07; C07D; C07D311/00; C07D311/02; C07D311/78; C07D311/80; C07D311/82; C12P; C12P17/00; C12P17/16; C12P17/162; C12R; C12R2001/00; C12R2001/645; C12R2001/80; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/911; Y10S435/933
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
11 words
Plastatin, having the structural formula ##STR2## and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
11 words
Plastatin, having the structural formula ##STR2## and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
41 words
A process for preparing plastatin which comprises cultivating Penicillium chermesinum A.T.C.C. No. 20700 in an aqueous nutrient medium containing an assimilable carbohydrate and nitrogen source under submerged aerobic conditions until substantial phospholipase A 2 inhibitory activity is imparted to the medium.
Claim 4
Dependent Claim
41 words
A process for preparing plastatin which comprises cultivating Penicillium chermesinum A.T.C.C. No. 20700 in an aqueous nutrient medium containing an assimilable carbohydrate and nitrogen source under submerged aerobic conditions until substantial phospholipase A 2 inhibitory activity is imparted to the medium.
Claim 5
Dependent Claim
16 words
A process in accordance with claim 2 wherein the organism is cultivated at about 25° C.
Claim 6
Dependent Claim
37 words
A biologically pure culture of the microorganism Penicillium chermesinum A.T.C.C. No. 20700, said culture being capable of producing plastatin in a recoverable quantity upon fermentation in an aqueous nutrient medium containing an assimilable carbohydrate and nitrogen source.
Claim 7
Dependent Claim
37 words
A biologically pure culture of the microorganism Penicillium chermesinum A.T.C.C. No. 20700, said culture being capable of producing plastatin in a recoverable quantity upon fermentation in an aqueous nutrient medium containing an assimilable carbohydrate and nitrogen source.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-08-26 | 1989-02-25 | 1989-08-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-08-26 | 1993-02-25 | 1993-08-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-08-26 | 1997-02-25 | 1997-08-27 | $7700.00 | Window Closed / Lapsed |