7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful in the treatment of thrombolytic disease

Claim 1

A compound having the structural formula ##STR39## and including all stereoisomers thereof; wherein m is 1 to 4; n is 1 to 8; p is 1 to 4; R is H, lower alkyl or alkali metal; and R 1 is lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl or lower alkenyl, wherein the term lower alkyl or alkyl by itself or as part of another group contains 1 to 12 carbons and is unsubstituted or substituted with halo, trifluoromethyl, alkoxy, aryl, alkyl-aryl, haloaryl, cycloalkyl or alkylcycloalkyl; the term aryl by itself or as part of another group contains 6 to 10 carbons and is unsubstituted or substituted with 1 or 2 lower alkyl groups 1 or 2 halogen groups and/or 1 or 2 lower alkoxy groups; the term cycloalkyl by itself or as part of another group contains 3 to 12 carbons and is unsubstituted or substituted with 1 or 2 halogens, 1 or 2 lower alkyl groups and/or 1 or 2 lower alkoxy groups; the term lower alkenyl by itself or as part of another group contains 2 to 12 carbons; the terms (CH 2 ) m and (CH 2 ) p include 1 to 4 carbons in the normal chain and the term (CH 2 ) n includes 1 to 8 carbons in the normal chain; and the terms (CH 2 ) m (CH 2 ) n and (CH 2 ) p may be unsubstituted or include one or more lower alkyl substituents.