Triazoleamine derivatives having histamine H2 -antagonist properties

Claim 1

Compounds of the general formula (I) ##STR24## and physiologically acceptable salts, hydrates; and tautomers thereof, in which R 1 and R 2 , which may be the same or different, each represent hydrogen, C 1-10 alkyl, C 3-8 cycloalkyl, C 3-6 alkenyl, aralkyl in which the alkyl moiety contains 1 to 6 carbon atoms; trifluoro C 1-6 alkyl, or C 1-6 alkyl substituted by hydroxy, C 1-6 alkoxy, amino, C 1-6 alkylamino or di C 1-6 alkylamino or R 1 and R 2 may together with the nitrogen atom to which they are attached form a heterocyclic ring which is pyrrolidine, piperidine optionally substituted in the 4-position by C 1-3 alkyl or hydroxy; tetrahydropyridine, morpholine, 2,6-di C 1-6 alkylmorpholine, hexamethyleneimine or heptamethylenimine; Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms; Q represents a furan or thiophene ring in which incorporation into the rest of the molecule is through bonds at the 2- and 5-positions, the furan ring optionally bearing a further substituent R 6 adjacent to the group R 1 R 2 N--Alk--, or Q represents a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1- and 3- or 1- and 4-positions; R 6 represents halogen or C 1-4 alkyl which may be substituted by hydroxy or C 1-4 alkoxy; X represents --CH 2 --, --O--, --S-- or ##STR25## where R 5 represents hydrogen or methyl; n represents zero, 1 or 2; m represents 2, 3 or 4; R 3 represents hydrogen, C 1-6 alkyl, C 3-6 alkenyl, ar C 1-6 alkyl, hydroxy C 2-6 alkyl, C 1-6 alkoxy C 1-6 alkyl or phenyl optionally substituted by one or more C 1-3 alkyl or alkoxy groups or halogen atoms; and R 4 represents hydrogen, C 1-6 alkyl, C 3-6 alkenyl, phenyl optionally substituted by one or more C 1-3 alkyl or alkoxy groups or halogen atoms; aralkyl in which the alkyl moiety contains 1 to 6 carbon atoms; hydroxy C 1-6 alkyl, acyloxy C 1-6 alkyl in which the acyl portion is C 1-6 alkanoyl, benzoyl optionally substituted by 1 or more C 1-3 alkyl or alkoxy groups or halogen atoms, or aralkanoyl in which the alkyl moiety contains 1 to 6 carbon atoms; C 1-6 alkoxy C 1-6 alkyl, aryloxy C 1-6 alkyl, ar C 1-6 alkyloxy C 1-6 alkyl; amino C 1-6 alkyl, C 1-6 alkyl-amino C 1-6 alkyl, di C 1-6 alkylamino C 1-6 alkyl, hydroxy, C 1-6 alkoxy, C 1-6 alkythio or halogen and wherein aryl or as a group or part of a group is phenyl optionally substituted by one or more C 1-3 alkyl or alkoxy groups or halogen atoms.