US4535161A
Expired / Lapsed
US
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Benzoquinolizine derivatives
Assignee: Daiichi Pharmaceutical Co Ltd
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Filing: 1983-06-27
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Granted: 1985-08-13
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Expires: 2003-06-27
Abstract
Abstract Benzoquinolizine derivatives of formula (I) ##STR1## wherein: X 1 represents a hydrogen atom or a halogen atom, R 1 represents a cyclic amino group which may contain additional hetero atom(s) of N,S and O and may be substituted with one or more substituents selected from the group consisting of hydroxyl, amino, alkyl, mono- or di-alkylamino, hydroxyalkyl and aminoalkyl, and physiologically acceptable salts thereof, having antibacterial activity.
Inventors
- 👤 Isao Hayakawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 22:31
CPC Classifications
C; C07; C07D; C07D455/00; C07D455/03; C07D455/04; A; A61; A61P; A61P31/00; A61P31/04; C07C; C07C205/00; C07C205/27; C07C205/35; C07C205/36; C07C205/37; C07D215/00; C07D215/02; C07D215/16; C07D215/18; C07D215/58; C07D215/60; C07D265/00; C07D265/28; C07D265/34; C07D265/36
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
110 words
A benzoquinolizine derivative of formula (I) ##STR5## wherein: X 1 represents a hydrogen atom or a halogen atom and R 1 represents a 4- to 7-membered saturated cyclic amino group selected from the group consisting of a 1-azetidinyl, a substituted pyrrolidinyl, 1-piperidinyl, 1-piperazinyl and 4-morpholinyl which may be substituted with one or more substituents selected from the group consisting of hydroxyl group, amino group, alkyl group, mono- or di-alkylamino group, hydroxyalkyl group and aminoalkyl group, wherein the alkyl moiety in said one or more substituents contains 1 to 6 carbon atoms, a nitrogen atom of said cyclic amino group being bonded to the benzoquinolizine moiety, and physiologically acceptable salts thereof.
Claim 2
Dependent Claim
110 words
A benzoquinolizine derivative of formula (I) ##STR5## wherein: X 1 represents a hydrogen atom or a halogen atom and R 1 represents a 4- to 7-membered saturated cyclic amino group selected from the group consisting of a 1-azetidinyl, a substituted pyrrolidinyl, 1-piperidinyl, 1-piperazinyl and 4-morpholinyl which may be substituted with one or more substituents selected from the group consisting of hydroxyl group, amino group, alkyl group, mono- or di-alkylamino group, hydroxyalkyl group and aminoalkyl group, wherein the alkyl moiety in said one or more substituents contains 1 to 6 carbon atoms, a nitrogen atom of said cyclic amino group being bonded to the benzoquinolizine moiety, and physiologically acceptable salts thereof.
Claim 3
Dependent Claim
14 words
A compound as claimed in claim 1, wherein X 1 is a fluorine atom.
Claim 4
Dependent Claim
22 words
A compound as claimed in claim 1, wherein X 1 is a fluorine atom and R 1 is a substituted pyrrolidinyl group.
Claim 5
Dependent Claim
21 words
A compound as claimed in claim 1, wherein X 1 is a fluorine atom and R 1 is a 3-hydroxy-1-pyrrolidinyl group.
Claim 6
Dependent Claim
21 words
A compound as claimed in claim 1, wherein X 1 is a fluorine atom and R 1 is a 3-amino-1-pyrrolidinyl group.
References Cited (Backward Citations)
US4301289A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-08-12 | 1989-02-11 | 1989-08-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-08-12 | 1993-02-11 | 1993-08-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-08-12 | 1997-02-11 | 1997-08-13 | $7700.00 | Window Closed / Lapsed |