Aminoindazole derivatives

Abstract

Abstract A compound of the formula (I): ##STR1## wherein W 1 and W 2 each independently is a hydrogen atom or a ##STR2## group wherein Y is a n-C 1-6 alkylene group or a n-C 1-6 alkylene group having a C 1-6 alkyl group substituent; and R 1 and R 2 each independently is a hydrogen atom or a C 1-6 alkyl group, and ##STR3## group in ##STR4## group may form a saturated heterocyclic ring selected from the group consisting of morpholino, pyrrolidino, piperidino, homopiperidino and piperazino groups, and the saturated heterocyclic ring except the morpholino group may have at least one C 1-4 alkyl group, hydroxyl group or halogen atom as a substituent; Z 1 is a hydrogen atom, a chlorine atom, a bromine atom, an iodine atom, a hydroxyl group, an amino group, a C 1-3 alkyl group or a methoxy group; Z 2 is a hydrogen atom or an amino group; when W 1 and W 2 are both hydrogen atoms, Z 1 is a hydroxyl group or an iodine atom and Z 2 is hydrogen atom, or Z 1 and Z 2 are both amino groups; when Z 1 and Z 2 are both hydrogen atoms, the ##STR5## group in either W 1 or W 2 is a morpholino group; when Z 1 is a chlorine atom, a hydroxyl group, an iodine atom, a methyl group or a methoxy group, Z 2 is a hydrogen atom; when Z 1 is an amino group, Z 2 is a hydrogen atom or an amino group; when Z 1 is a methyl group, a methoxy group or an amino group, Z 1 is in the 5-position; when Z 1 is an iodine atom, Z 1 is in the 5- or 7-position; and when Z 1 and Z 2 are both amino groups, Z 1 and Z 2 are in the 5- and 7-positions; and the physiologically acceptable acid addition salt thereof which compounds have pharmaceutical utility, e.g.: treating inflammation.

Inventors

• 👤 Tadayuki Ibuki
• 👤 Taisuke Sugihara
• 👤 Hiromu Kawakubo
• 👤 Takanori Sone

Bibliographic Details