US4529600A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pentadeuterioretinoids
Assignee: SRI International Inc
•
Filing: 1982-09-09
•
Granted: 1985-07-16
•
Expires: 2002-09-09
Abstract
Abstract Retinoic acid-4,4,18,18,18-d5 and esters and amides thereof are disclosed. These compounds are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.
Inventors
- 👤 Marcia I. Dawson
- 👤 Peter D. Hobbs
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 03:28
CPC Classifications
C; C07; C07C; C07C403/00; C07C403/20; C07B; C07B2200/00; C07B2200/05; C07B2200/09; C07C2601/00; C07C2601/12; C07C2601/16
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
42 words
A compound of the formula ##STR3## where R is hydroxyl, alkoxy of 1 to about 8 carbon atoms, or NR 1 R 2 where R 1 is hydrogen, alkyl, or aryl and R 2 is alkyl or aryl and 13-cis isomers thereof.
Claim 2
Dependent Claim
42 words
A compound of the formula ##STR3## where R is hydroxyl, alkoxy of 1 to about 8 carbon atoms, or NR 1 R 2 where R 1 is hydrogen, alkyl, or aryl and R 2 is alkyl or aryl and 13-cis isomers thereof.
Claim 3
Dependent Claim
58 words
The compound of claim 1 wherein said alkoxy contains 1 to 4 carbon atoms and said alkyl groups represented by R 1 and R 2 each contain 1 to 4 carbon atoms and have 0 to 1 hydroxy substituent and said aryl groups represented by R 1 and R 2 each contain 6 to about 15 carbon atoms.
Claim 4
Dependent Claim
4 words
(E)-Retinoic acid-4,4,18,18,18-d 5 .
Claim 5
Dependent Claim
4 words
(E)-Retinoic acid-4,4,18,18,18-d 5 .
Claim 6
Dependent Claim
4 words
Ethyl (E)-retinoate-4,4,18,18,18-d 5 .
Claim 7
Dependent Claim
4 words
Ethyl (E)-retinoate-4,4,18,18,18-d 5 .
Claim 8
Dependent Claim
33 words
A therapeutic composition for treating a dermatosis or a proliferative skin disease comprising a therapeutically effective amount of the compound of claim 1, 2, 3, or 4 combined with a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
33 words
A method of inhibiting tumor promotion in epithelial cells of a living animal comprising administering a tumor promotion inhibiting amount of the compound of claim 1, 2, 3, or 4 to the animal.
Claim 10
Dependent Claim
11 words
The method of claim 6 wherein the animal is a human.
Claim 11
Dependent Claim
34 words
A method of treating a living animal for a dermatosis or a proliferative skin disease comprising administering a therapeutically effective amount of the compound of claim 1, 2, 3, or 4 to the animal.
Claim 12
Dependent Claim
17 words
The method of claim 8 wherein the compound is administered topically to the affected area of skin.
Claim 13
Dependent Claim
11 words
The method of claim 8 wherein the animal is a human.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-15 | 1989-01-14 | 1989-07-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-15 | 1993-01-14 | 1993-07-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-15 | 1997-01-14 | 1997-07-16 | $7700.00 | Window Closed / Lapsed |