US4529593A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of gallium salts to treat disorders of calcium homeostasis
Assignee: Memorial Sloan Kettering Cancer Center
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Filing: 1984-06-20
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Granted: 1985-07-16
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Expires: 2004-06-20
Abstract
Abstract The present invention comprises a method of preventing or treating a disorder associated with accelerated loss of calcium from bone in a human individual comprising administering to the individual a pharmaceutically acceptable gallium compound. Of especial importance among the disorders which may be thus prevented or treated are hypercalcemia, accelerated bone loss associated with osteopenia, osteoporosis, bone metastasis due to malignant tumors, and hyperparathyroidism. In the method of the present invention gallium compounds may be administered by any and all routes. Although all biocompatible, soluble compounds of gallium may be used in the present invention, gallium nitrate is preferred, most preferably in a pharmaceutically acceptable carrier.
Inventors
- 👤 Raymond P. Warrell, Jr.
- 👤 Richard S. Bockman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 18:26
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/24; A61P; A61P3/00; A61P3/12; A61P3/14; A61P43/00
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
30 words
Method effective against excessive loss of calcium from bone in a human individual requiring such treatment comprising administering to the individual an effective amount of a pharmaceutically acceptable gallium compound.
Claim 2
Dependent Claim
30 words
Method effective against excessive loss of calcium from bone in a human individual requiring such treatment comprising administering to the individual an effective amount of a pharmaceutically acceptable gallium compound.
Claim 3
Dependent Claim
12 words
Method of claim 1 wherein said excess loss is due to hypercalcemia.
Claim 4
Dependent Claim
14 words
Method of claim 1 wherein said excess loss is due to osteopenia or osteoporosis.
Claim 5
Dependent Claim
16 words
Method of claim 1 wherein said excess loss is due to bone metastasis from malignant tumors.
Claim 6
Dependent Claim
12 words
Method of claim 1 wherein said excess loss is due to hyperparathyroidism.
Claim 7
Dependent Claim
34 words
Method of claim 1 wherein said excess loss is due to periodontal disease and said gallium compound is administered intra-orally in a topical formulation comprising a concentrated rinse, gel or other pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
30 words
Method effective against excessive loss of calcium from bone in animals requiring such treatment comprising the administering to said animals of an effective amount of a pharmaceutically acceptable gallium compound.
Claim 9
Dependent Claim
30 words
Method effective against excessive loss of calcium from bone in animals requiring such treatment comprising the administering to said animals of an effective amount of a pharmaceutically acceptable gallium compound.
Claim 10
Dependent Claim
17 words
Method of inhibiting release of calcium from bone explants comprising contacting said explants with a gallium compound.
Claim 11
Dependent Claim
17 words
Method of inhibiting release of calcium from bone explants comprising contacting said explants with a gallium compound.
Claim 12
Dependent Claim
14 words
Method of claim 1 wherein said gallium compound is administered intravenously, subcutaneously or intramuscularly.
Claim 13
Dependent Claim
10 words
Method of claim 3 wherein intravenous injection comprises continuous infusion.
Claim 14
Dependent Claim
15 words
Method of claim 9 wherein said injection comprises amount ranging from about 10-400 mg/sq m/day.
Claim 15
Dependent Claim
27 words
Method of claim 1 wherein the amount of said administered gallium compound is sufficient to maintain a steady state plasma gallium concentration ranging from about 0.1-5.0 ug/ml.
Claim 16
Dependent Claim
26 words
Method claim 12 wherein the amount of said administered gallium compound is sufficient to maintain a steady state plasma gallium concentration ranging from about 0.9-2.0 ug/ml.
Claim 17
Dependent Claim
16 words
Method of claim 1 wherein said gallium compound is administered orally, sub-lingually, per rectum or transdermally.
Claim 18
Dependent Claim
17 words
Method of claim 14 wherein the amount of administered gallium compound comprises amounts from about 0.5-20 grams/day.
Claim 19
Dependent Claim
37 words
Method of claim 1 wherein said gallium compound is selected from the group consisting of gallium nitrate, gallium citrate, gallium halide, gallium chloride, gallium carbonate, gallium acetate, gallium tartrate, gallium oxalate, gallium oxide and hydrated gallium oxide.
Claim 20
Dependent Claim
11 words
Method of claim 16 wherein said gallium compound is gallium nitrate.
Claim 21
Dependent Claim
11 words
Method of claim 2 wherein said gallium compound is gallium nitrate.
Claim 22
Dependent Claim
11 words
Method of claim 3 wherein said gallium compound is gallium nitrate.
Claim 23
Dependent Claim
11 words
Method of claim 4 wherein said gallium compound is gallium nitrate.
Claim 24
Dependent Claim
11 words
Method of claim 5 wherein said gallium compound is gallium nitrate.
Claim 25
Dependent Claim
11 words
Method of claim 6 wherein said gallium compound is gallium nitrate.
Claim 26
Dependent Claim
33 words
Method effective against bone pain due to excessive loss of calcium from bone in a human individual requiring such treatment comprising administering to the individual an effective amount of pharmaceutically acceptable gallium compound.
Claim 27
Dependent Claim
33 words
Method effective against bone pain due to excessive loss of calcium from bone in a human individual requiring such treatment comprising administering to the individual an effective amount of pharmaceutically acceptable gallium compound.
Claim 28
Dependent Claim
34 words
Method effective against bone fractures due to excessive loss of calcium from bone in human a individual requiring such treatment comprising administering to the individual an effective amount of a pharmaceutically acceptable gallium compound.
Claim 29
Dependent Claim
34 words
Method effective against bone fractures due to excessive loss of calcium from bone in human a individual requiring such treatment comprising administering to the individual an effective amount of a pharmaceutically acceptable gallium compound.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-15 | 1989-01-14 | 1989-07-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-15 | 1993-01-14 | 1993-07-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-15 | 1997-01-14 | 1997-07-16 | $7700.00 | Window Closed / Lapsed |