US4528392A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aromatic compounds as antiallergic agents
Assignee: Wyeth LLC
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Filing: 1984-04-18
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Granted: 1985-07-09
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Expires: 2004-04-18
Abstract
Abstract There are disclosed compounds of the formula ##STR1## wherein X is OR 2 , SR 2 , N(R 2 ) 2 or halo; W is --CH 2 --, ##STR2## Y is --CH 2 O--, --OCH 2 --, --CH 2 S--, --SCH 2 --, ##STR3## m is 0-6; n is 0-6; p is 1-3; A is O or S; B is OR 2 , SR 2 or N(R 2 ) 2 ; R 1 is hydrogen, loweralkyl, loweralkoxy or halo; R 2 is hydrogen or loweralkyl; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like.
Inventors
- 👤 John H. Musser
- 👤 Kenneth L. Kees
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 19:26
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/18; C07D207/22; C07D207/24; C07D207/26; C07D207/273; C07D207/277; C07C; C07C205/00; C07C205/27; C07C205/35
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
83 words
A compound having the formula ##STR17## wherein X is OR 2 ,SR 2 ,N(R 2 ) 2 or halo; W is ##STR18## Y is --CH 2 O--, --OCH 2 --, --CH 2 S--, --SCH 2 --, ##STR19## m is 0-6; n is 0-6; p is 1-3; A is O or S; B is OR 2 ,SR 2 or N(R 2 ) 2 ; R 1 is hydrogen, loweralkyl, loweralkoxy or halo; R 2 is hydrogen or loweralkyl; and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
83 words
A compound having the formula ##STR17## wherein X is OR 2 ,SR 2 ,N(R 2 ) 2 or halo; W is ##STR18## Y is --CH 2 O--, --OCH 2 --, --CH 2 S--, --SCH 2 --, ##STR19## m is 0-6; n is 0-6; p is 1-3; A is O or S; B is OR 2 ,SR 2 or N(R 2 ) 2 ; R 1 is hydrogen, loweralkyl, loweralkoxy or halo; R 2 is hydrogen or loweralkyl; and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
11 words
The compound of claim 1, which is 3-[[3-[(4-acetyl-3-hydroxyphenoxy)methyl]phenyl]amino]-3-oxopropanoic acid, methyl ester.
Claim 4
Dependent Claim
11 words
The compound of claim 1, which is 4-[[3-[(4-acetyl-3-hydroxyphenoxy)methyl]phenyl]amino]-4-oxobutanoic acid, methyl ester.
Claim 5
Dependent Claim
11 words
The compound of claim 1 which is 2-[[3-[(4-acetyl-3-hydroxyphenoxy)methyl]phenyl]amino]oxalic acid, methyl ester.
Claim 6
Dependent Claim
11 words
The compound of claim 1, which is 5-[[3-[(4-acetyl-3-hydroxyphenoxy)methyl]phenyl]-5-oxo-pentanoic acid, methyl ester.
Claim 7
Dependent Claim
11 words
The compound of claim 1, which is 3-[[3-[(4-acetyl-3-methoxyphenoxy)methyl]phenyl]amino]-3-oxopropanoic acid, methyl ester.
Claim 8
Dependent Claim
11 words
The compound of claim 1, which is 4-[[3-[(4-acetyl-3-methoxy-phenoxy)methyl]phenyl]amino]-4-oxobutanoic acid, methyl ester.
Claim 9
Dependent Claim
11 words
The compound of claim 1, which is 3-[[3-[[3-hydroxy-4-(1-oxohexyl)phenoxy]methyl]phenyl]amino]-3-oxopropanoic acid, methyl ester.
Claim 10
Dependent Claim
11 words
The compound of claim 1, which is 4-[[3-[[3-hydroxy-4-(1-oxohexyl)phenoxy]methyl]phenyl]amino]-4-oxobutanoic acid, methyl ester.
Claim 11
Dependent Claim
11 words
The compound of claim 1, which is 4-[[3-[[3-methoxy-4-(1-oxohexyl)phenoxy]methyl]phenyl]amino]-4-oxobutanoic acid, methyl ester.
Claim 12
Dependent Claim
11 words
The compound of claim 1, which is 3-[[3-[[3-methoxy-4-(1-oxohexyl)phenoxy]methyl]phenyl]amino]-3-oxopropanoic acid, methyl ester.
Claim 13
Dependent Claim
11 words
The compound of claim 1, which is 4-[[3-[(4-acetyl-3-fluorophenoxy)methyl]phenyl]amino]-4-oxobutanoic acid, methyl ester.
Claim 14
Dependent Claim
11 words
The compound of claim 1, which is 2-[[3-[(4-acetyl-3-fluorophenoxy)methyl]phenyl]amino]-oxalic acid, methyl ester.
Claim 15
Dependent Claim
11 words
The compound of claim 1, which is 5-[[3-[(4-acetyl-3-fluorophenoxy)methyl]phenyl]amino]-5-oxopentanoic acid, methyl ester.
Claim 16
Dependent Claim
11 words
The compound of claim 1, which is 3-[[3-[(4-acetyl-3-fluorophenoxy)methyl]phenyl]amino]-3-oxopropanoic acid, methyl ester.
Claim 17
Dependent Claim
6 words
The compound 3-[[3-[(4-hexyl-3-methoxyphenoxy)methyl]phenyl]amino]-3-oxopropanoic acid, methyl ester.
Claim 18
Dependent Claim
6 words
The compound 3-[[3-[(4-hexyl-3-methoxyphenoxy)methyl]phenyl]amino]-3-oxopropanoic acid, methyl ester.
Claim 19
Dependent Claim
6 words
The compound 4-[[3-[(4-hexyl-3-methoxyphenoxy)methyl]phenyl]amino]-4-oxobutanoic acid, methyl ester.
Claim 20
Dependent Claim
6 words
The compound 4-[[3-[(4-hexyl-3-methoxyphenoxy)methyl]phenyl]amino]-4-oxobutanoic acid, methyl ester.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-08 | 1989-01-07 | 1989-07-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-08 | 1993-01-07 | 1993-07-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-08 | 1997-01-07 | 1997-07-09 | $7700.00 | Window Closed / Lapsed |