US4528287A
Expired / Lapsed
US
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6-Fluoro-1, 4-dihydro-4-oxo-7-substituted piperazinylquinoline-3-carboxylic acids and the method for preparing the same
Assignee: Abbott Japan Co Ltd
•
Filing: 1984-09-17
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Granted: 1985-07-09
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Expires: 2004-09-17
Abstract
Abstract The invention is concerned with the novel piperazinylquinoline-3-carboxylic acids represented by formula (I) <IMAGE> (I) or a pharmacologically-acceptable salt thereof, a process for the preparation of them, and a pharmaceutical composition which contains these new compounds as active ingredient and can be used as the therapeutic agent against bacteria.
Inventors
- 👤 Yasuo Itoh
- 👤 Hideo Kato
- 👤 Nobuo Ogawa
- 👤 Eiichi Koshinaka
- 👤 Tomio Suzuki
- 👤 Noriyuki Yagi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 02:15
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D215/00; C07D215/02; C07D215/16; C07D215/48; C07D215/54; C07D215/56
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
85 words
A 6-fluoro-1,4-dihydro-4-oxo-7-substituted piperazinyl-quinoline-3-carboxylic acids represented by the general formula (I) ##STR12## wherein R 1 is a lower alkyl group having 1 to 4 carbon atoms, a vinyl group, a 2-fluoroethyl group, or a 2-hydroxy-ethyl group; R 2 , R 3 and R 4 each is a hydrogen, or a lower alkyl group having 1 to 4 carbon atoms; R 5 is a lower alkyl group having 1 to 4 carbon atoms and R 6 is a hydrogen, or a fluorine and a pharmacologically-acceptable salt thereof.
Claim 2
Dependent Claim
85 words
A 6-fluoro-1,4-dihydro-4-oxo-7-substituted piperazinyl-quinoline-3-carboxylic acids represented by the general formula (I) ##STR12## wherein R 1 is a lower alkyl group having 1 to 4 carbon atoms, a vinyl group, a 2-fluoroethyl group, or a 2-hydroxy-ethyl group; R 2 , R 3 and R 4 each is a hydrogen, or a lower alkyl group having 1 to 4 carbon atoms; R 5 is a lower alkyl group having 1 to 4 carbon atoms and R 6 is a hydrogen, or a fluorine and a pharmacologically-acceptable salt thereof.
Claim 3
Dependent Claim
8 words
Compound of claim 1 which is 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piprazinyl)-4-oxoquinoline-3-carboxylic acid.
Claim 4
Dependent Claim
9 words
Compound of claim 1 which is 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride.
Claim 5
Dependent Claim
9 words
Compound of claim 1 which is 1-Ethyl-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride.
Claim 6
Dependent Claim
8 words
Compound of claim 1 which is 6-Fluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid.
Claim 7
Dependent Claim
8 words
Compound of claim 1 which is 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid.
Claim 8
Dependent Claim
8 words
Compound of claim 1 which is 6,8-Difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-1-vinylquinoline-3-carboxylic acid.
Claim 9
Dependent Claim
8 words
Compound of claim 1 which is 6,8-Difluoro-1,4-dihydro-1-methyl-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid.
Claim 10
Dependent Claim
33 words
Pharmaceutical compositions useful for the inhibition of bacteria and for increased urinary excretion comprising an effective antibacterial amount of one or more compounds as claimed in claim 1 together with a, pharmaceutically-acceptable carrier.
Claim 11
Dependent Claim
41 words
Method for the inhibition of bacteria and for increasing urinary excretion in a subject in need of the same, comprising the step of administering an effective antibacterial and urinary-excretion increasing amount of a compound of claim 1 orally to said patient.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-08 | 1989-01-07 | 1989-07-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-08 | 1993-01-07 | 1993-07-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-08 | 1997-01-07 | 1997-07-09 | $7700.00 | Window Closed / Lapsed |