US4526988A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Difluoro antivirals and intermediate therefor
Assignee: Eli Lilly and Co
•
Filing: 1983-03-10
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Granted: 1985-07-02
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Expires: 2003-03-10
Abstract
Abstract A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.
Inventors
- 👤 Larry W. Hertel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 12:10
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07D; C07D307/00; C07D307/02; C07D307/26; C07D307/30; C07D307/32; C07D307/33; A; A61; A61P; A61P31/00; A61P31/12; C07D317/00; C07D317/08; C07D317/10; C07D317/14; C07D317/30; C07H11/00; C07H19/16; C07H5/00; C07H5/02; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
38 words
A process for preparing a lactone of the formula ##STR11## which process comprises hydrolyzing, under very mild conditions, an alkyl 3-dioxolanyl-2,2-difluoro-3-hydroxypropionate of the formula ##STR12## wherein R 4 and R 5 are independently C 1 -C 3 alkyl.
Claim 2
Dependent Claim
38 words
A process for preparing a lactone of the formula ##STR11## which process comprises hydrolyzing, under very mild conditions, an alkyl 3-dioxolanyl-2,2-difluoro-3-hydroxypropionate of the formula ##STR12## wherein R 4 and R 5 are independently C 1 -C 3 alkyl.
Claim 3
Dependent Claim
20 words
A process of claim 1 wherein the propionate is a compound wherein R 4 and R 5 are methyl groups.
Claim 4
Dependent Claim
16 words
A process of claim 2 wherein the hydrolysis reagent is a mildly acidic ion exchange resin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-01 | 1988-12-31 | 1989-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-01 | 1992-12-31 | 1993-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-01 | 1996-12-31 | 1997-07-02 | $7700.00 | Window Closed / Lapsed |