US4526893A
Expired / Lapsed
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Isocarbostyril derivatives
Assignee: Nisshin Seifun Group Inc
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Filing: 1983-12-16
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Granted: 1985-07-02
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Expires: 2003-12-16
Abstract
Abstract Compounds of the structure ##STR1## wherein X, R 1 , R 2 , R 3 , R 4 , and R 5 are as herein defined, effective as β-blockers and hypotensive agents, are described.
Inventors
- 👤 Toshihiro Takahashi
- 👤 Noriyoshi Sueda
- 👤 Masahiro Tsuji
- 👤 Yoshiyuki Tahara
- 👤 Hiroyasu Koyama
- 👤 Yoshikuni Suzuki
- 👤 Masao Nagase
- 👤 Toshiji Sugai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 13:10
CPC Classifications
C; C07; C07D; C07D217/00; C07D217/22; C07D217/24; A; A61; A61P; A61P25/00; A61P25/02; A61P27/00; A61P27/02; A61P27/06; A61P9/00; A61P9/06; A61P9/08; A61P9/10; A61P9/12
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
80 words
Isocarbostyril derivative represented by the general formula ##STR56## wherein R 1 denotes hydrogen atom or a lower alkyl group, R 2 and R 3 denote hydrogen atom or a lower alkyl group, respectively, R 4 and R 5 denote hydrogen atom, halogen atom, a lower alkyl group, lower alkoxy group, hydroxy group, amino group, lower acylamino group, nitro group, lower alkylmercapto group, carbamoyl group, sulfamoyl group or hydroxyalkyl group, respectively, and X denotes oxygen atom, sulfur atom or imino group.
Claim 2
Dependent Claim
80 words
Isocarbostyril derivative represented by the general formula ##STR56## wherein R 1 denotes hydrogen atom or a lower alkyl group, R 2 and R 3 denote hydrogen atom or a lower alkyl group, respectively, R 4 and R 5 denote hydrogen atom, halogen atom, a lower alkyl group, lower alkoxy group, hydroxy group, amino group, lower acylamino group, nitro group, lower alkylmercapto group, carbamoyl group, sulfamoyl group or hydroxyalkyl group, respectively, and X denotes oxygen atom, sulfur atom or imino group.
Claim 3
Dependent Claim
1 words
4-[3-{2-(2,4-dimethoxyphenoxy)-1-methylethylamino}-2-hydroxypropoxy]isocarbostyril.
Claim 4
Dependent Claim
1 words
4-[3-{2-(2,4-dimethoxyphenoxy)-1-methylethylamino}-2-hydroxypropoxy]isocarbostyril.
Claim 5
Dependent Claim
1 words
4[3-{2-(2-methoxyphenoxy)-1-methylethylamino}-2-hydroxypropoxy]isobcarbostyril.
Claim 6
Dependent Claim
1 words
4[3-{2-(2-methoxyphenoxy)-1-methylethylamino}-2-hydroxypropoxy]isobcarbostyril.
Claim 7
Dependent Claim
88 words
A pharmaceutical composition which comprises as an active ingredient a compound of the general formula ##STR57## wherein R 1 denotes hydrogen atom or a lower alkyl group, R 2 and R 3 denote hydrogen atom or a lower alkyl group, respectively, R 4 and R 5 denote hydrogen atom, halogen atom, a lower alkyl group, lower alkoxy group, hydroxy group, amino group, lower acylamino group, nitro group, lower alkylmercapto group, carbamoyl group, sulfamoyl group or hydroxyalkyl group, respectively, and X denotes oxygen atom, sulfur atom or imino group.
Claim 8
Dependent Claim
88 words
A pharmaceutical composition which comprises as an active ingredient a compound of the general formula ##STR57## wherein R 1 denotes hydrogen atom or a lower alkyl group, R 2 and R 3 denote hydrogen atom or a lower alkyl group, respectively, R 4 and R 5 denote hydrogen atom, halogen atom, a lower alkyl group, lower alkoxy group, hydroxy group, amino group, lower acylamino group, nitro group, lower alkylmercapto group, carbamoyl group, sulfamoyl group or hydroxyalkyl group, respectively, and X denotes oxygen atom, sulfur atom or imino group.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-01 | 1988-12-31 | 1989-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-01 | 1992-12-31 | 1993-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-01 | 1996-12-31 | 1997-07-02 | $7700.00 | Window Closed / Lapsed |