US4525355A
Expired / Lapsed
US
⏱️ 0.0 years remaining
7-β-Ureidoacetamido-oxacephalosporins
Assignee: Shionogi and Co Ltd
•
Filing: 1983-12-27
•
Granted: 1985-06-25
•
Expires: 2003-12-27
Abstract
Abstract A 7β-ureidoacetamido-7α-methoxy-3-(1-carbamoylmethyl-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid derivative represented by the following formula: ##STR1## wherein Ar is phenyl, hydroxyphenyl, or thienyl and R is hydrogen, a light metal, or a carboxy-protecting group.
Inventors
- 👤 Masayuki Narisada
- 👤 Fumihiko Watanabe
- 👤 Tetsuo Okada
- 👤 Hiromu Matsumura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 05:41
CPC Classifications
C; C07; C07D; C07D505/00; A; A61; A61P; A61P31/00; A61P31/04; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
28 words
A 7β-ureidoacetamido-7α-methoxy-3-(1-carbamoylmethyl-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid derivative represented by the following formula: ##STR16## wherein Ar is phenyl, hydroxyphenyl, or thienyl and R is hydrogen, a light metal, or a carboxy-protecting group.
Claim 2
Dependent Claim
28 words
A 7β-ureidoacetamido-7α-methoxy-3-(1-carbamoylmethyl-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid derivative represented by the following formula: ##STR16## wherein Ar is phenyl, hydroxyphenyl, or thienyl and R is hydrogen, a light metal, or a carboxy-protecting group.
Claim 3
Dependent Claim
13 words
A compound as claimed in claim 1 wherein Ar is phenyl or thienyl.
Claim 4
Dependent Claim
19 words
A compound as claimed in claim 1 wherein R is hydrogen, sodium, potassium, diphenylmethyl, p-methoxybenzyl, acetoxymethyl, 1-(ethoxycarbonyloxy)ethyl, or pivaloyloxymethyl.
Claim 5
Dependent Claim
18 words
Any one of the following compounds: 7β-[2-(2-thienyl)-2-ureidoacetamido]-7α-methoxy-3-(1-carbamoylmethyl-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid, sodium 7β-[2-(2-thienyl)-2-ureidoacetamido]-7α-methoxy-3-(1-carbamoylmethyl-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylate, pivaloyloxymethyl 7β-[2-(2-thienyl)-2-ureidoacetamido]-7α-methoxy-3-(1-carbamoylmethyl-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylate, β -(2-phenyl-2-ureidoacetamido)-7α-methoxy-3-(1-carbamoylmethyl-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid, and sodium 7β-(2-phenyl-2-ureidoacetamido)-7α-methoxy-3-(1-carboxylmethyl-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylate.
Claim 6
Dependent Claim
18 words
Any one of the following compounds: 7β-[2-(2-thienyl)-2-ureidoacetamido]-7α-methoxy-3-(1-carbamoylmethyl-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid, sodium 7β-[2-(2-thienyl)-2-ureidoacetamido]-7α-methoxy-3-(1-carbamoylmethyl-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylate, pivaloyloxymethyl 7β-[2-(2-thienyl)-2-ureidoacetamido]-7α-methoxy-3-(1-carbamoylmethyl-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylate, β -(2-phenyl-2-ureidoacetamido)-7α-methoxy-3-(1-carbamoylmethyl-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid, and sodium 7β-(2-phenyl-2-ureidoacetamido)-7α-methoxy-3-(1-carboxylmethyl-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylate.
Claim 7
Dependent Claim
14 words
A compound as claimed in claim 1 wherein the 7-side chain is in D-form.
Claim 8
Dependent Claim
18 words
An antibacterial composition comprising an effective amount of the compound as claimed in claim 1 and conventional carrier.
Claim 9
Dependent Claim
24 words
A method for combating bacteria which comprises bringing an effective amount of the compound as claimed in claim 1 to contact with the bacteria.
References Cited (Backward Citations)
US4232151A
Cited
US4371532A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-24 | 1988-12-24 | 1989-06-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-24 | 1992-12-24 | 1993-06-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-24 | 1996-12-24 | 1997-06-25 | $7700.00 | Window Closed / Lapsed |