US4525346A
Expired / Lapsed
US
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Aqueous antimicrobial ophthalmic solutions
Assignee: Alcon Research LLC
•
Filing: 1983-09-29
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Granted: 1985-06-25
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Expires: 2003-09-29
Abstract
Abstract This invention relates to ophthalmic compositions which comprise quaternary ammonium salt having the formula <IMAGE> +TR CH2CHCHCH2]nN+(CH2CH2OH)3(n + 2)X- wherein X=a pharmaceutically acceptable anion, such compositions providing aqueous disinfecting solutions for contact lenses as well as a preserved ocular compositions including contact lens treating solutions comfort drop solutions, preserved saline solutions, ointments and other ocular medicaments.
Inventors
- 👤 Raymond L. Stark
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 06:41
CPC Classifications
A; A61; A61L; A61L12/00; A61L12/08; A61L12/14; A61L12/143; A61L12/145; A61K; A61K31/00; A61K31/74; A61K31/785; A61K9/00; A61K9/0012; A61K9/0048
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
73 words
An aqueous ophthalmic contact lens solution comprising: from about 0.00001 to about 3.0 percent by weight/volume of a quaternary ammonium compound having a number average molecular weight in the range of about 2,000 to about 30,000, said compound having the formula ##STR3## wherein X=a pharmaceutically acceptable anion; an effective amount of NaCl to provide isotonicity to said solution; and an effective amount of buffer to provide said solution with an ophthalmically acceptable pH.
Claim 2
Dependent Claim
73 words
An aqueous ophthalmic contact lens solution comprising: from about 0.00001 to about 3.0 percent by weight/volume of a quaternary ammonium compound having a number average molecular weight in the range of about 2,000 to about 30,000, said compound having the formula ##STR3## wherein X=a pharmaceutically acceptable anion; an effective amount of NaCl to provide isotonicity to said solution; and an effective amount of buffer to provide said solution with an ophthalmically acceptable pH.
Claim 3
Dependent Claim
17 words
An aqueous ophthalmic solution as recited in claim 1 wherein said solution further comprises a wetting agent.
Claim 4
Dependent Claim
20 words
An aqueous ophthalmic solution as recited in claim 2 wherein said solution further comprises a chelating agent and a surfactant.
Claim 5
Dependent Claim
30 words
The ophthalmic solution as recited in claims 1, 2 or 3 wherein the quaternary ammonium compound has a molecular weight in the range of from about 3,000 to about 14,000.
Claim 6
Dependent Claim
16 words
An ophthalmic solution as recited in claim 1 wherein said solution is a preserved saline solution.
Claim 7
Dependent Claim
21 words
An ophthalmic solution as recited in claim 1 wherein said solution is a preserved disinfecting solution for a soft contact lens.
Claim 8
Dependent Claim
17 words
An ophthalmic solution as recited in claim 2 wherein said solution is a preserved comfort drop solution.
Claim 9
Dependent Claim
15 words
An ophthalmic solution as recited in claim 3 wherein said solution is a cleaning solution.
Claim 10
Dependent Claim
13 words
An aqueous ophthalmic solution as recited in claim 1 wherein X=Cl - .
Claim 11
Dependent Claim
21 words
An aqueous ophthalmic soft contact lens solution as recited in claim 1 wherein said contact lens is a soft contact lens.
Claim 12
Dependent Claim
21 words
An aqueous ophthalmic soft contact lens solution as recited in claim 1 or 10 wherein said anion is Cl - .
Claim 13
Dependent Claim
36 words
The aqueous ophthalmic soft contact lens solution as recited in claim 1 wherein said quaternary ammonium compound has a molecular weight sufficiently large to substantially preclude adsorption, absorption or physical binding onto a soft contact lens.
Claim 14
Dependent Claim
20 words
An aqueous ophthalmic soft contact lens solution as recited in claim 12 wherein said solution further comprises a wetting agent.
Claim 15
Dependent Claim
19 words
An aqueous ophthalmic soft contact lens solution as recited in claim 12 wherein said anion is Cl - .
Claim 16
Dependent Claim
23 words
An aqueous ophthalmic soft contact lens solution as recited in claim 13 wherein said solution further comprises a chelating agent and a surfactant.
Claim 17
Dependent Claim
34 words
An ophthalmic soft contact lens solution as recited in claims 12, 13, 14 or 15, wherein the quaternary ammonium compound has a molecular weight in the range of from about 3,000 to about 14,000.
Claim 18
Dependent Claim
75 words
An isotonic contact lens disinfecting solution comprising from about 0.001 to about 0.01 percent by weight/volume of a quaternary ammonium compound having a number average molecular weight in the range of about 2,000 to about 30,000, said quaternary ammonium compound having the formula ##STR4## wherein X=a pharmaceutically acceptable anion; an effective amount of NaCl to provide isotonicity to said solution; an effective amount of a buffer to provide said solution with an ophthalmically acceptable pH.
Claim 19
Dependent Claim
75 words
An isotonic contact lens disinfecting solution comprising from about 0.001 to about 0.01 percent by weight/volume of a quaternary ammonium compound having a number average molecular weight in the range of about 2,000 to about 30,000, said quaternary ammonium compound having the formula ##STR4## wherein X=a pharmaceutically acceptable anion; an effective amount of NaCl to provide isotonicity to said solution; an effective amount of a buffer to provide said solution with an ophthalmically acceptable pH.
Claim 20
Dependent Claim
29 words
A contact lens disinfecting solution as recited in claim 17 wherein said quaternary ammonium compound has a molecular weight in the range of from about 3,000 to about 14,000.
Claim 21
Dependent Claim
46 words
An isotonic contact lens disinfecting solution as recited in claims 17 or 18 wherein said solution further includes ethylenediaminetetracetic acid or salts thereof and a wetting agent selected from the group consisting of polyvinyl alcohol, polyvinyl pyrrolidone, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, polyvidone and mixtures thereof.
Claim 22
Dependent Claim
15 words
An isotonic contact lens disinfecting solution as recited in claim 18 wherein X=Cl - .
Claim 23
Independent Claim
61 words
A method of imparting antimicrobial activity to an aqueous ophthalmic contact lens solution comprising: adding to said solution from about 0.00001% to about 3.0% by weight/volume of a quaternary ammonium salt as an antimicrobial agent having a molecular weight in the range of about 3,000 to about 14,000, said quaternary ammonium salt having the formula ##STR5## wherein X=a pharmaceutically acceptable anion.
Claim 24
Independent Claim
61 words
A method of imparting antimicrobial activity to an aqueous ophthalmic contact lens solution comprising: adding to said solution from about 0.00001% to about 3.0% by weight/volume of a quaternary ammonium salt as an antimicrobial agent having a molecular weight in the range of about 3,000 to about 14,000, said quaternary ammonium salt having the formula ##STR5## wherein X=a pharmaceutically acceptable anion.
Claim 25
Dependent Claim
31 words
A method as recited in claim 21 wherein said antimicrobial agent preserves said solution and wherein said ammonium salt comprises from about 0.0001% to about 0.005% by weight/volume of said solution.
Claim 26
Dependent Claim
31 words
A method as recited in claim 21 wherein said antimicrobial agent comprises from about 0.001% to about 0.01% by weight/volume of said solution and wherein said solution disinfects a contact lens.
Claim 27
Independent Claim
19 words
A method as recited in claims 21, 22 or 23 wherein the pharmaceutically acceptable anion is Cl - .
Claim 28
Independent Claim
19 words
A method as recited in claims 21, 22 or 23 wherein the pharmaceutically acceptable anion is Br - .
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-24 | 1988-12-24 | 1989-06-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-24 | 1992-12-24 | 1993-06-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-24 | 1996-12-24 | 1997-06-25 | $7700.00 | Window Closed / Lapsed |