US4522826A
Expired / Lapsed
US
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Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same
Assignee: Richardson Vicks Inc
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Filing: 1984-02-08
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Granted: 1985-06-11
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Expires: 2004-02-08
Abstract
Abstract Novel pharmaceutical compositions of matter are provided comprising analgesic/non-steroidal anti-inflammatory drugs and diphenhydramine and methods of using said compositions to elicit an enhanced analgesic and/or anti-inflammatory response in mammalian organisms in need of such treatment.
Inventors
- 👤 Abraham Sunshine
- 👤 Eugene M. Laska
- 👤 Carole E. Siegel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 05:16
CPC Classifications
A; A61; A61K; A61K45/00; A61K45/06; A61K31/00; A61K31/185; A61K31/19; A61K31/33; A61K31/395; A61K31/40; A61P; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 46
Claim 1
Independent Claim
70 words
A method for eliciting an enhanced analgesic and anti-inflammatory response in a mammalian organism in need of such treatment, comprising administering to such organism (i) an analgesically and anti-inflammatorily effective amount of ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen or bucloxic acid or a pharmaceutically acceptable salt thereof, and (ii) an analgesically and anti-inflammatorily potentiating amount of diphenhydramine.
Claim 2
Independent Claim
70 words
A method for eliciting an enhanced analgesic and anti-inflammatory response in a mammalian organism in need of such treatment, comprising administering to such organism (i) an analgesically and anti-inflammatorily effective amount of ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen or bucloxic acid or a pharmaceutically acceptable salt thereof, and (ii) an analgesically and anti-inflammatorily potentiating amount of diphenhydramine.
Claim 3
Dependent Claim
20 words
A method as defined by claim 1, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of ibuprofen.
Claim 4
Dependent Claim
20 words
A method as defined by claim 1, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of naproxen.
Claim 5
Dependent Claim
20 words
A method as defined by claim 1, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of flurbiprofen.
Claim 6
Dependent Claim
20 words
A method as defined by claim 1, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of fenoprofen.
Claim 7
Dependent Claim
20 words
A method as defined by claim 1, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of ketoprofen.
Claim 8
Dependent Claim
20 words
A method as defined by claim 1, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of fenbufen.
Claim 9
Dependent Claim
15 words
A method as defined by claim 1, comprising from about 50 to 400 mg ibuprofen.
Claim 10
Dependent Claim
15 words
A method as defined by claim 8, comprising from about 100 to 400 mg ibuprofen.
Claim 11
Dependent Claim
15 words
A method as defined by claim 1, comprising from about 12.5 to 50 mg diphenhydramine.
Claim 12
Dependent Claim
15 words
A method as defined by claim 10, comprising from about 25 to 50 mg diphenhydramine.
Claim 13
Dependent Claim
13 words
A method as defined by claim 1, wherein said composition is administered orally.
Claim 14
Dependent Claim
30 words
A method as defined by claim 12, wherein said composition is administered daily in divided doses comprising from about 100 to 400 mg ibuprofen and 25 to 50 mg diphenhydramine.
Claim 15
Dependent Claim
24 words
A method as defined by claim 1, wherein said composition is administered orally at bedtime as an analgesically and anti-inflammatorily effective nighttime sleep aid.
Claim 16
Dependent Claim
66 words
A pharmaceutical composition of matter for eliciting an enhanced analgesic and anti-inflammatory response in a mammalian organism, said composition comprising: (i) an analgesically and anti-inflammatorily effective amount of ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen or bucloxic acid or a pharmaceutically acceptable salt thereof, and (ii) an analgesically and anti-inflammatorily potentiating amount of diphenhydramine.
Claim 17
Dependent Claim
66 words
A pharmaceutical composition of matter for eliciting an enhanced analgesic and anti-inflammatory response in a mammalian organism, said composition comprising: (i) an analgesically and anti-inflammatorily effective amount of ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen or bucloxic acid or a pharmaceutically acceptable salt thereof, and (ii) an analgesically and anti-inflammatorily potentiating amount of diphenhydramine.
Claim 18
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of ibuprofen.
Claim 19
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of naproxen.
Claim 20
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of benoxaprofen.
Claim 21
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of flurbiprofen.
Claim 22
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of fenoprofen.
Claim 23
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of fenbufen.
Claim 24
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of ketoprofen.
Claim 25
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of indoprofen.
Claim 26
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of pirprofen.
Claim 27
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of carprofen.
Claim 28
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of oxaprozin.
Claim 29
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of pranoprofen.
Claim 30
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of miroprofen.
Claim 31
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of tioxaprofen.
Claim 32
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of suprofen.
Claim 33
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of alminoprofen.
Claim 34
Dependent Claim
23 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of tiaprofenic acid.
Claim 35
Dependent Claim
22 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of fluprofen.
Claim 36
Dependent Claim
23 words
The composition of matter as defined by claim 15, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of bucloxic acid.
Claim 37
Dependent Claim
17 words
The composition of matter as defined by claim 15, further comprising a non-toxic pharmaceutically acceptable inert carrier.
Claim 38
Dependent Claim
17 words
The composition of matter as defined by claim 16, comprising from about 50 to 400 mg ibuprofen.
Claim 39
Dependent Claim
16 words
A composition of matter as defined by claim 15, comprising from 12.5 to 50 mg diphenhydramine.
Claim 40
Dependent Claim
20 words
A composition of matter as defined by claim 15, wherein said diphenhydramine is present as the pharmaceutically acceptable salt thereof.
Claim 41
Dependent Claim
25 words
A composition of matter as defined by claim 15, comprising from about 100 to 400 mg ibuprofen and from about 25 to 50 mg diphenhydramine.
Claim 42
Dependent Claim
16 words
A composition of matter as defined by claim 15, said composition being adapted for oral administration.
Claim 43
Dependent Claim
19 words
A composition of matter as defined by claim 40, said composition being formulated as a tablet, capsule or elixir.
Claim 44
Dependent Claim
20 words
A composition of matter as defined by claim 15, said composition being adapted for oral administration in sustained release form.
Claim 45
Dependent Claim
16 words
A composition of matter as defined by claim 15, said composition being adapted for parenteral administration.
Claim 46
Dependent Claim
16 words
A composition of matter as defined by claim 43, said composition being formulated for intramuscular administration.
References Cited (Backward Citations)
US4362728A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-10 | 1988-12-10 | 1989-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-10 | 1992-12-10 | 1993-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-10 | 1996-12-10 | 1997-06-11 | $7700.00 | Window Closed / Lapsed |