US4522819A
Expired / Lapsed
US
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1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and metal salts thereof useful in burn therapy
Assignee: Warner Chilcott Pharmaceuticals Inc
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Filing: 1982-06-23
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Granted: 1985-06-11
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Expires: 2002-06-23
Abstract
Abstract 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and metal salts thereof wherein the metal moiety is selected from the group consisting of silver, zinc, cerium and cobalt are useful in the treatment of burns. These compounds may be applied to the affected surface of a burn victim either directly or as part of a composition together with a physiologically acceptable carrier, such as a water-dispersible, hydrophilic carrier.
Inventors
- 👤 Charles L. Fox, Jr.
- 👤 Shanta M. Modak
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 20:39
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/48; C07D215/54; C07D215/56; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
23 words
A metal salt of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid wherein the metal moiety is selected from the group consisting of silver, zinc, cerium, and cobalt.
Claim 2
Dependent Claim
23 words
A metal salt of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid wherein the metal moiety is selected from the group consisting of silver, zinc, cerium, and cobalt.
Claim 3
Dependent Claim
14 words
A metal salt in accordance with claim 1 wherein the metal moiety is silver.
Claim 4
Dependent Claim
14 words
A metal salt in accordance with claim 1 wherein the metal moiety is zinc.
Claim 5
Dependent Claim
14 words
A metal salt in accordance with claim 1 wherein the metal moiety is cerous.
Claim 6
Independent Claim
57 words
A method of treating surface bacterial infections in animal or man which comprises applying a composition containing an effective antibacterial amount of a metal salt of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and a physiologically acceptable carrier to the affected surface, the metal moiety of said metal salt being selected from the group consisting of silver, zinc, cerium, and cobalt.
Claim 7
Independent Claim
57 words
A method of treating surface bacterial infections in animal or man which comprises applying a composition containing an effective antibacterial amount of a metal salt of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and a physiologically acceptable carrier to the affected surface, the metal moiety of said metal salt being selected from the group consisting of silver, zinc, cerium, and cobalt.
Claim 8
Dependent Claim
28 words
A method of treating burns in animal or man which comprises topically applying an effective antibacterial amount of the metal salt of claim 1 to the affected surface.
Claim 9
Dependent Claim
25 words
A composition useful for treating burns which comprises an effective amount of a metal salt in accordance with claim 1 and a physiologically acceptable carrier.
Claim 10
Dependent Claim
27 words
A method of treating burns in animal or man which comprises topically applying an effective antibacterial amount of the composition of claim 7 to the affected surface.
Claim 11
Dependent Claim
23 words
A composition in accordance with claim 7 wherein said effective amount is an amount from about 0.01 to about 1.0 percent by weight.
Claim 12
Dependent Claim
17 words
A composition in accordance with claim 7 wherein said physiologically acceptable carrier is a water-dispersible hydrophilic carrier.
Claim 13
Dependent Claim
23 words
A composition in accordance with claim 7 wherein said physiologically acceptable carrier is a semi-soft or cream-like, water-dispersible or water-soluble oil-in-water emulsion carrier.
Claim 14
Dependent Claim
23 words
A composition useful for treating burns which comprises an effective amount of the silver salt of claim 2 and a physiologically acceptable carrier.
Claim 15
Dependent Claim
23 words
A composition in accordance with claim 12 wherein said effective amount is an amount from about 0.01 to about 1.0 percent by weight.
Claim 16
Dependent Claim
17 words
A composition in accordance with claim 12 wherein said physiologically acceptable carrier is a water-dispersible hydrophilic carrier.
Claim 17
Dependent Claim
23 words
A composition in accordance with claim 12 wherein said physiologically acceptable carrier is a semi-soft or cream-like, water-dispersible or water-soluble oil-in-water emulsion carrier.
Claim 18
Dependent Claim
23 words
A composition useful for treating burns which comprises an effective amount of the zinc salt of claim 3 and a physiologically acceptable carrier.
Claim 19
Dependent Claim
23 words
A composition in accordance with claim 16 wherein said effective amount is an amount from about 0.01 to about 1.0 percent by weight.
Claim 20
Dependent Claim
17 words
A composition in accordance with claim 16 wherein said physiologically acceptable carrier is a water-dispersible hydrophilic carrier.
Claim 21
Dependent Claim
23 words
A composition in accordance with claim 16 wherein said physiologically acceptable carrier is a semi-soft or cream-like, water-dispersible or water-soluble oil-in-water emulsion carrier.
Claim 22
Dependent Claim
27 words
A method of treating burns in animal or man which comprises topically applying an effective antibacterial amount of the composition of claim 2 to the affected surface.
Claim 23
Dependent Claim
22 words
A method of treating burns in animal or man which comprises topically applying the composition of claim 16 to the affected surface.
Claim 24
Dependent Claim
22 words
A method of treating burns in animal or man which comprises topically applying the composition of claim 12 to the affected surface.
Claim 25
Dependent Claim
22 words
A method of treating burns in animal or man which comprises topically applying the composition of claim 7 to the affected surface.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-10 | 1988-12-10 | 1989-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-10 | 1992-12-10 | 1993-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-10 | 1996-12-10 | 1997-06-11 | $7700.00 | Window Closed / Lapsed |