US4521416A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones
Assignee: Warner Lambert Co LLC
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Filing: 1983-03-22
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Granted: 1985-06-04
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Expires: 2003-03-22
Abstract
Abstract 4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones 6-[(substituted)-1H- imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and pharmaceutically acceptable acid addition salts thereof are useful as cardiotonic and antihypertensive agents. The above compounds cause a significant increase in myocardial contractility in the dog and also cause a decrease in blood pressure in the spontaneously hypertensive rat. The compounds are produced by reacting the appropriate γ-oxo-imidazolebutanoic acid with a suitably substituted hydrazine to provide 4,5-dihydro-6-(substituted)imidazolyl-3(2H)-pyridazinones which are oxidized to 6-(substituted)imidazolyl-3(2H)-pyridazinones.
Inventors
- 👤 Ila Sircar
- 👤 James A. Bristol
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 02:20
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64; A; A61; A61P; A61P9/00; A61P9/04; A61P9/12; C07D403/00; C07D403/02; C07D403/04
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
49 words
A compound of the formula ##STR8## wherein is a single or double bond; A is hydrogen, lower alkyl, phenyl, phenyl substituted by lower alkyl, halo or trifluoromethyl, or pyridinyl; R, R 1 , and R 2 are independently hydrogen or lower alkyl, and pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
49 words
A compound of the formula ##STR8## wherein is a single or double bond; A is hydrogen, lower alkyl, phenyl, phenyl substituted by lower alkyl, halo or trifluoromethyl, or pyridinyl; R, R 1 , and R 2 are independently hydrogen or lower alkyl, and pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
12 words
A compound as claimed in claim 1 and of the formula ##STR9##
Claim 4
Dependent Claim
21 words
A compound as claimed in claim 2, wherein R and R 1 are independently hydrogen or methyl, and A is phenyl.
Claim 5
Dependent Claim
12 words
A compound as claimed in claim 1 and of the formula ##STR10##
Claim 6
Dependent Claim
21 words
A compound as claimed in claim 4, wherein R and R 1 are independently hydrogen or methyl, and A is phenyl.
Claim 7
Dependent Claim
10 words
A compound as claimed in claim 4 and being 4,5-dihydro-6-(1-methyl-2-phenyl-1H-imidazol-4-yl)-3(2H)-pyridazinone.
Claim 8
Dependent Claim
10 words
A compound as claimed in claim 3 and being 6-(1-methyl-2-phenyl-1H-imidazol-4-yl)-3(2H)-pyridazinone.
Claim 9
Dependent Claim
28 words
A pharmaceutical composition for increasing cardiac contractility or lowering blood pressure comprising an effective amount of a compound as claimed in claim 1 with a pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
37 words
The method for increasing cardiac contractility in a patient requiring such treatment which comprises administering orally or parenterally to such patient an effective amount of a compound as claimed in claim 1 and a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
37 words
The method of lowering blood pressure in a patient suffering from hypertension which comprises administering orally or parenterally to such patient an effective amount of a compound as claimed in claim 1 and a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-03 | 1988-12-03 | 1989-06-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-03 | 1992-12-03 | 1993-06-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-03 | 1996-12-03 | 1997-06-04 | $7700.00 | Window Closed / Lapsed |