US4521352A
Expired / Lapsed
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Microencapsulation process
Assignee: Mars Inc
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Filing: 1982-08-09
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Granted: 1985-06-04
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Expires: 2002-08-09
Abstract
Abstract In a microencapsulation process involving an interfacial polymerization reaction between a compound containing amine groups and a polybasic acid chloride or anhydride, the polymerization being carried out in an emulsion of an aqueous solution in a hydrophobic organic liquid, the reaction is terminated by introducing water into the hydrophobic phase of the emulsion where it reacts with and destroys the residual acid chloride or anhydride.
Inventors
- 👤 Lawrence T. Hayworth
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 08:35
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5089; B; B01; B01J; B01J13/00; B01J13/02; A23; A23K; A23K40/00; A23K40/30; B01J13/06; B01J13/14; B01J13/16; Y; Y10; Y10S; Y10S426/00; Y10S426/805; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
85 words
A process for microencapsulating an aqueous amine solution, which process comprises emulsifying the aqueous amine solution in a hydrophobic organic liquid to form droplets, reacting the amine with a polybasic acid chloride or anhydride to form a polymer membrane around individual droplets by interfacial polymerization, and then terminating the polymerization reaction by introducing water into the hydrophobic organic liquid by adding to the reaction mixture a solution of water in an organic liquid, which solution of water is wholly miscible with the hydrophobic organic liquid.
Claim 2
Dependent Claim
85 words
A process for microencapsulating an aqueous amine solution, which process comprises emulsifying the aqueous amine solution in a hydrophobic organic liquid to form droplets, reacting the amine with a polybasic acid chloride or anhydride to form a polymer membrane around individual droplets by interfacial polymerization, and then terminating the polymerization reaction by introducing water into the hydrophobic organic liquid by adding to the reaction mixture a solution of water in an organic liquid, which solution of water is wholly miscible with the hydrophobic organic liquid.
Claim 3
Dependent Claim
25 words
A process according to claim 1 wherein the organic liquid in which water is dissolved is an aliphatic alcohol containing up to 5 carbon atoms.
Claim 4
Dependent Claim
19 words
A process according to claim 2, wherein the alcohol is methanol, ethanol, n-propanol, isopropanol, n-butanol, butan-2-ol, or n-amyl alcohol.
Claim 5
Dependent Claim
22 words
A process according to claim 2, wherein the reaction is terminated by addition of an approximately 3% solution of water in ethanol.
Claim 6
Dependent Claim
25 words
A process according to claim 2, wherein the aqueous amine solution is an aqueous solution of hydrophilic protein containing a plurality of free amine groups.
Claim 7
Dependent Claim
22 words
A process according to claim 5, wherein the aqueous amine solution is emulsified in an organic liquid comprising a substantially non-polar solvent.
Claim 8
Dependent Claim
12 words
A process as in claim 1 wherein said amine is a protein.
Claim 9
Dependent Claim
29 words
A process as in claim 1 wherein said hydrophobic organic liquid is cyclohexane and said solution of water in an organic liquid is a solution of water in ethanol.
Claim 10
Dependent Claim
29 words
A process according to claim 1, wherein the acid chloride or anhydride is sebacoyl chloride, succinoyl chloride, adipoyl chloride, phthaloyl chloride, terephthaloyl chloride or citroyl chloride or succinic anhydride.
Claim 11
Dependent Claim
20 words
A process according to claim 1, wherein following termination of the reaction the solvent phase is decanted off the capsules.
Claim 12
Dependent Claim
20 words
A process according to claim 10, wherein following separation of the capsules from the solvent phase the capsules are dried.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-03 | 1988-12-03 | 1989-06-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-03 | 1992-12-03 | 1993-06-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-03 | 1996-12-03 | 1997-06-04 | $7700.00 | Window Closed / Lapsed |