Phenyl alpha-acyloxyacetamide derivatives and their therapeutic use

Claim 2

A therapeutic composition comprising an antipruritic or antiinflammatory effective amount of a phenyl-alpha-acyloxyacetamide compound having the formula: ##STR3## wherein R 1 , R 2 =H, alkyl or aralkyl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms, R 3 =alkyl, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; R 4 =H, alkyl, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; and the hydrogen atom of the phenyl, R 1 , R 2 , R 3 or R 4 may be substituted by a nonfunctional halogen or a radical such as a lower alkyl or alkoxy having 1 to 9 carbon atoms; and the carbon atom of R 1 or R 2 may be substituted by a nonfunctional N, S or O, in a pharmaceutically acceptable vehicle for topical application to involved body areas or internal administration.

Claim 3

The phenyl-alpha-acyloxyacetamide compound of claim 1 wherein the compound is a member selected from the group consisting of: N-ethyl phenyl-alpha-acetoxyacetamide N-phenethyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-phenylacetoxyacetamide N-phenethyl phenyl-alpha-phenylacetoxyacetamide N-ethyl phenyl-alpha-benzoyloxyacetamide N-allyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-lauroyloxyacetamide N-phenethyl phenyl-alpha-linoleoyloxyacetamide N-phenethyl phenyl-alpha-linolenoyloxyacetamide N-isopropyl phenyl-alpha-acetoxyacetamide N-t-butyl phenyl-alpha-acetoxyacetamide N-p-chlorobenxyl phenyl-alpha-acetoxyacetamide N-p-methoxybenzyl phenyl-alpha-acetoxyacetamide N-p-methoxyphenethyl phenyl-alpha-acetoxyacetamide N-benzyl phenyl-alpha-acetoxyacetamide N-(3,4-dimethoxyphenethyl) phenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminoethyl) phenyl-alpha-acetoxyacetamide N-hydroxyethylthioethylphenyl-alpha-acetoxyacetamide N-(2-phenylethanol) phenyl-alpha-acetoxyacetamide N,N-dibenzyl phenyl-alpha-acetoxyacetamide N-hydroxyethoxyethyl phenyl-alpha-acetoxyacetamide N-diphenylmethyl phenyl-alpha-acetoxyacetamide N-p-fluorobenzyl phenyl-alpha-acetoxyacetamide N-p-methylbenzyl phenyl-alpha-acetoxyacetamide N-p-chlorophenethyl phenyl-alpha-acetoxyacetamide N-phenylpropyl phenyl-alpha-acetoxyacetamide; and N-phenylbutyl phenyl-alpha-acetoxyacetamide.

Claim 4

The phenyl-alpha-acyloxyacetamide compound of claim 1 wherein the compound is a member selected from the group consisting of: N-ethyl-diphenyl-alpha-acetoxyacetamide N-phenethyl diphenly-alpha-acetoxyacetamide N-ethyl diphenyl-alpha-phenylacetoxyacetamide N-phenethyl diphenyl-alpha-phenylacetoxyacetamide N-isopropyl diphenyl alpha-acetoxyacetamide N-t-butyl diphenyl alpha-acetoxyacetamide N-benzyl diphenyl-alpha-acetoxyacetamide N-allyl diphenyl-alpha-acetoxyacetamide N,N-diethyl diphenyl-alpha-acetozyacetamide N-(N',N'-diethylaminoethyl) diphenyl-alpha-acetoxyacetamide N-P-chlorobenzyl diphenyl-alpha-acetoxy-acetamide N-P-methoxybenzyl diphenyl-alpha-acetoxy-acetamide N-P-methoxyphenethyl diphenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminopropyl) diphenyl-alpha-acetoxyacetamide N-(N',N'-dimethylamino propyl) diphenyl-alpha-acetoxyacetamide N-p-fluorobenzyl diphenyl-alpha-acetoxyacetamide N-p-methylbenzyl diphenyl-alpha-acetoxyacetamide N-p-chlorophenethyl diphenyl-alpha-acetoxyacetamide N-phenylpropyl diphenyl-alpha-acetoxyacetamide; and N-phenylbutyl diphenyl-alpha-acetoxyacetamide.

Claim 5

A therapeutic composition comprising, in combination, an antipruritic, or antiinflammatory-enhancing effectice amount of a phenyl-alpha-acyloxyacetamide compound having the formula: ##STR4## wherein:

Claim 6

A therapeutic composition comprising, in combination, an antipruritic, or antiinflammatory-enhancing effectice amount of a phenyl-alpha-acyloxyacetamide compound having the formula: ##STR4## wherein:

Claim 7

R 1 , R 2 =H, alkyl or aralkyl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms, R 3 =aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; R 4 =H, alkyl, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; and the hydrogen atom of the phenyl, R 1 , R 2 , R 3 or R 4 may be substituted by a nonfunctional halogen or a radical such as a lower alkyl or alkoxy having 1 to 9 carbon atoms; and the carbon atom of R 1 or R 2 may be substituted by a nonfunctional N, S or O; an effective amount a dermatologic agent effective as an antiyeast, antifungal, antibacterial, antiviral, antiinflammatory, keratolytic, antipsoriatic, or antieczematic agent in a pharmaceutically acceptable vehicle for topical application to involved body areas or internal administration.

Claim 8

R 1 , R 2 =H, alkyl or aralkyl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms, R 3 =aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; R 4 =H, alkyl, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; and the hydrogen atom of the phenyl, R 1 , R 2 , R 3 or R 4 may be substituted by a nonfunctional halogen or a radical such as a lower alkyl or alkoxy having 1 to 9 carbon atoms; and the carbon atom of R 1 or R 2 may be substituted by a nonfunctional N, S or O; an effective amount a dermatologic agent effective as an antiyeast, antifungal, antibacterial, antiviral, antiinflammatory, keratolytic, antipsoriatic, or antieczematic agent in a pharmaceutically acceptable vehicle for topical application to involved body areas or internal administration.

Claim 9

The phenyl-alpha-acyloxyacetamide compound of claim 4 wherein the compound is a member selected from the group consisting of: N-ethyl phenyl-alpha-acetoxyacetamide N-phenethyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-phenylacetoxyacetamide N-phenethyl phenyl-alpha-phenylacetoxyacetamide N-benzyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-benzoyloxyacetamide N-allyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-lauroyloxyacetamide N-phenethyl phenyl-alpha-linoleoyloxyacetamide N-phenethyl phenyl-alpha-linolenoyloxyacetamide N-isopropyl phenyl-alpha-acetoxyacetamide N-t-butyl phenyl-alpha-acetoxyacetamide N-p-chlorobenzyl phenyl-alpha-acetoxyacetamide N-p-methoxybenzyl phenyl-alpha-acetoxyacetamide N-p-methoxyphenethyl phenyl-alpha-acetoxyacetamide N-(3,4-dimethoxyphenethyl) phenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminoethyl) phenyl-alpha-acetoxyacetamide N-hydroxyethylthioethylphenyl-alpha-acetoxyacetamide N-(2-phenylethanol) phenyl-alpha-acetoxyacetamide N,N-dibenzyl phenyl-alpha-acetoxyacetamide N-hydroxyethoxyethyl phenyl-alpha-acetoxyacetamide N-diphenylmethyl phenyl-alpha-acetoxyacetamide N-p-fluorobenzyl phenyl-alpha-acetoxyacetamide N-p-methylbenzyl phenyl-alpha-acetoxyacetamide N-p-chlorophenethyl phenyl-alpha-acetoxyacetamide N-phenylpropyl phenyl-alpha-acetoxyacetamide N-phenylbutyl phenyl-alpha-acetoxyacetamide.

Claim 10

The phenyl-alpha-acyloxyacetamide compound of claim 4 wherein the compound is a member selected from the group consisting of: N-ethyl diphenyl-alpha-acetoxyacetamide N-phenethyl diphenyl-alpha-acetoxyacetamide N-ethyl diphenyl-alpha-phenylacetoxyacetamide N-phenethyl diphenyl-alpha-phenylacetoxyacetamide N-isopropyl diphenyl alpha-acetoxyacetamide N-t-butyl diphenyl alpha-acetoxyacetamide N-benzyl diphenyl-alpha-acetoxyacetamide N-allyl diphenyl-alpha-acetoxyacetamide N,N-diethyl diphenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminoethyl) diphenyl-alpha-acetoxyacetamide N-P-chlorobenzyl diphenyl-alpha-acetoxy-acetamide N-P-methoxybenzyl diphenyl-alpha-acetoxy-acetamide N-P-methoxyphenethyl diphenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminopropyl) diphenyl-alpha-acetoxyacetamide N-(N",N'-dimethylamino propyl) diphenyl-alpha-acetoxyacetamide N-p-fluorobenzyl diphenyl-alpha-acetoxyacetamide N-p-methylbenzyl diphenyl-alpha-acetoxyacetamide N-p-chlorophenethyl diphenyl-alpha-acetoxyacetamide N-phenylpropyl diphenyl-alpha-acetoxyacetamide N-phenylbutyl diphenyl-alpha-acetoxyacetamide.

Claim 11

Method of treatment to induce antipruritic, anti-inflammatory, antiarthritic, antieczematic, analgesic and tranquilizing effects in humans and animals comprising the administration of a composition comprising a therapeutic effective amount of a phenyl-alpha-acyloxyacetamide compound having the formula: ##STR5## wherein R 1 , R 2 =H, alkyl or aralkyl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms, R 3 =alkyl, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; R 4 =H, alkyl, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; and the hydrogen atom of the phenyl, R 1 , R 2 , R 3 or R 4 may be substituted by a nonfunctional halogen or a radical such as a lower alkyl or alkoxy having 1 to 9 carbon atoms; and the carbon atom of R 1 or R 2 may be substituted by a nonfunctional N, S or O, in a pharmaceutically acceptable vehicle for topical application to involved body areas or internal administration.

Claim 12

Method of treatment to induce antipruritic, anti-inflammatory, antiarthritic, antieczematic, analgesic and tranquilizing effects in humans and animals comprising the administration of a composition comprising a therapeutic effective amount of a phenyl-alpha-acyloxyacetamide compound having the formula: ##STR5## wherein R 1 , R 2 =H, alkyl or aralkyl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms, R 3 =alkyl, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; R 4 =H, alkyl, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; and the hydrogen atom of the phenyl, R 1 , R 2 , R 3 or R 4 may be substituted by a nonfunctional halogen or a radical such as a lower alkyl or alkoxy having 1 to 9 carbon atoms; and the carbon atom of R 1 or R 2 may be substituted by a nonfunctional N, S or O, in a pharmaceutically acceptable vehicle for topical application to involved body areas or internal administration.

Claim 13

The phenyl-alpha-acyloxyacetamide of claim 7 wherein the compound is a member selected from the group consisting of: N-ethyl phenyl-alpha-acetoxyacetamide N-phenethyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-phenylacetoxyacetamide N-phenethyl phenyl-alpha-phenylacetoxyacetamide N-ethyl phenyl-alpha-benzoyloxyacetamide N-allyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-lauroyloxyacetamide N-phenethyl phenyl-alpha-linoleoyloxyacetamide N-phenethyl phenyl-alpha-linolenoyloxyacetamide N-isopropyl phenyl-alpha-acetoxyacetamide N-t-butyl phenyl-alpha-acetoxyacetamide N-p-chlorobenzyl phenyl-alpha-acetoxyacetamide N-p-methoxybenzyl phenyl-alpha-acetoxyacetamide N-p-methoxyphenethyl phenyl-alpha-acetoxyacetamide N-(3,4-dimethoxyphenethyl) phenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminoethyl) phenyl-alpha-acetoxyacetamide N-hydroxyethylthioethylphenyl-alpha-acetoxyacetamide N-(2-phenylethanol) phenyl-alpha-acetoxyacetamide N,N-dibenzyl phenyl-alpha-acetoxyacetamide N-hydroxyethoxyethyl phenyl-alpha-acetoxyacetamide N-diphenylmethyl phenyl-alpha-acetoxyacetamide N-p-fluorobenzyl phenyl-alpha-acetoxyacetamide N-p-methylbenzyl phenyl-alpha-acetoxyacetamide N-p-chlorophenethyl phenyl-alpha-acetoxyacetamide N-phenylpropyl phenyl-alpha-acetoxyacetamide N-phenylbutyl phenyl-alpha-acetoxyacetamide N-benzyl phenyl-alpha-acetoxyacetamide.

Claim 14

The phenyl-alpha-acyloxyacetamide of claim 7 wherein the compound is a member selected from the group consisting of: N-ethyl diphenyl-alpha-acetoxyacetamide N-phenethyl diphenyl-alpha-acetoxyacetamide N-ethyl diphenyl-alpha-phenylacetoxyacetamide N-phenethyl diphenyl-alpha-phenylacetoxyacetamide N-isopropyl diphenyl alpha-acetoxyacetamide N-t-butyl diphenyl alpha-acetoxyacetamide N-benzyl diphenyl-alpha-acetoxyacetamide N-allyl diphenyl-alpha-acetoxyacetamide N,N-diethyl diphenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminoethyl) diphenyl-alpha-acetoxyacetamide N-P-chlorobenzyl diphenyl-alpha-acetoxy-acetamide N-P-methoxybenzyl diphenyl-alpha-acetoxy-acetamide N-P-methoxyphenethyl diphenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminopropyl) diphenyl-alpha-acetoxyacetamide N-(N',N'-dimethylamino propyl) diphenyl-alpha acetoxyacetamide N-p-fluorobenzyl diphenyl-alpha-acetoxyacetamide N-p-methylbenzyl diphenyl-alpha-acetoxyacetamide N-p-chlorophenethyl diphenyl-alpha-acetoxyacetamide N-phenylpropyl diphenyl-alpha-acetoxyacetamide N-phenylbutyl diphenyl-alpha-acetoxyacetamide.

Claim 15

The method of claim 7 wherein the compound is a member selected from the group consisting: N-ethyl phenyl-alpha-acetoxyacetamide N-phenethyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-phenylacetoxyacetamide N-benzyl phenyl-alpha-acetoxyacetamide N-phenethyl phenyl-alpha-phenylacetoxyacetamide N-ethyl phenyl-alpha-benzoyloxyacetamide N-allyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-lauroyloxyacetamide N-phenethyl phenyl-alpha-linoleoyloxyacetamide N-phenethyl phenyl-alpha-linolenoyloxyacetamide N-isopropyl phenyl-alpha-acetoxyacetamide N-t-butyl phenyl-alpha-acetoxyacetamide N-p-chlorobenzyl phenyl-alpha-acetoxyacetamide N-p-methoxybenzyl phenyl-alpha-acetoxyacetamide N-p-methoxyphenethyl phenyl-alpha-acetoxyacetamide N-(3,4-dimethoxyphenethyl) phenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminoethyl) phenyl-alpha-acetoxyacetamide N-hydroxyethylthioethylphenyl-alpha-acetoxyacetamide N-(2-phenylethanol) phenyl-alpha-acetoxyacetamide N,N-dibenzyl phenyl-alpha-acetoxyacetamide N-hydroxyethoxyethyl phenyl-alpha-acetoxyacetamide N-diphenylmethyl phenyl-alpha-acetoxyacetamide N-p-fluorobenzyl phenyl-alpha-acetoxyacetamide N-p-methylbenzyl phenyl-alpha-acetoxyacetamide N-p-chlorophenethyl phenyl-alpha-acetoxyacetamide N-phenylpropyl phenyl-alpha-acetoxyacetamide; and N-phenylbutyl phenyl-alpha-acetoxyacetamide.

Claim 16

The method of claim 7 wherein the compound is a member selected from the group consisting of: N-ethyl diphenyl-alpha-acetoxyacetamide N-phenethyl diphenyl-alpha-acetoxyacetamide N-ethyl diphenyl-alpha-phenylacetoxyacetamide N-phenethyl diphenyl-alpha-phenylacetoxyacetamide N-isopropyl diphenyl alpha-acetoxyacetamide N-t-butyl diphenyl alpha-acetoxyacetamide N-benzyl diphenyl-alpha-acetoxyacetamide N-allyl diphenyl-alpha-acetoxyacetamide N,N-diethyl diphenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminoethyl) diphenyl-alpha-acetoxyacetamide N-P-chlorobenzyl diphenyl-alpha-acetoxy-acetamide N-P-methoxybenzyl diphenyl-alpha-acetoxy-acetamide N-P-methoxyphenethyl diphenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminopropyl) diphenyl-alpha-acetoxyacetamide N-(N',N'-dimethylamino propyl) diphenyl-alpha-acetoxyacetamide N-p-fluorobenzyl diphenyl-alpha-acetoxyacetamide N-p-methylbenzyl diphenyl-alpha-acetoxyacetamide N-p-chlorophenethyl diphenyl-alpha-acetoxyacetamide N-phenylpropyl diphenyl-alpha-acetoxyacetamide N-phenylbutyl diphenyl-alpha-acetoxyacetamide.

Claim 17

Method of treatment to induce antripruritic, anti-inflammatory, antiarthritic, antieczematic, analgesic and tranquilizing effects in humans and animals comprising the administration of a composition comprising, in combination, a therapeutic effect amount of a phenyl-alpha-acyloxyacetamide compound having the following formula: ##STR6## wherein R 1 , R 2 =H, alkyl or aralkyl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms, R 3 =alkyl, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; R 4 =H, alkyl, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; and the hydrogen atom of the phenyl, R 1 , R 2 , R 3 or R 4 may be substituted by a nonfunctional halogen or a radical such as a lower alkyl or alkoxy having 1 to 9 carbon atoms; and the carbon atom of R 1 or R 2 may be substituted by a nonfunctional N, S or O; an effective amount a dermatologic agent effective as an antiyeast, antifungal, antibacterial, antiviral, anti-inflammatory, keratolytic, antipsoriatic, or antieczematic agent in a pharmaceutically acceptable vehicle for topical application to involved body areas or internal administration.

Claim 18

Method of treatment to induce antripruritic, anti-inflammatory, antiarthritic, antieczematic, analgesic and tranquilizing effects in humans and animals comprising the administration of a composition comprising, in combination, a therapeutic effect amount of a phenyl-alpha-acyloxyacetamide compound having the following formula: ##STR6## wherein R 1 , R 2 =H, alkyl or aralkyl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms, R 3 =alkyl, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; R 4 =H, alkyl, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms; and the hydrogen atom of the phenyl, R 1 , R 2 , R 3 or R 4 may be substituted by a nonfunctional halogen or a radical such as a lower alkyl or alkoxy having 1 to 9 carbon atoms; and the carbon atom of R 1 or R 2 may be substituted by a nonfunctional N, S or O; an effective amount a dermatologic agent effective as an antiyeast, antifungal, antibacterial, antiviral, anti-inflammatory, keratolytic, antipsoriatic, or antieczematic agent in a pharmaceutically acceptable vehicle for topical application to involved body areas or internal administration.

Claim 19

The composition of claim 12 wherein said agent is a member selected from the group consisting of clotrimazole, miconazole, nystatin, neomycin, gramicidin, haloprogin, griseofulvin, salicylic acid, sodium thiosulfate, selenium sulfide, zinc pyrithione, benzyl benzoate, crotamiton, lindane, phenol, methol, amphotericins, penicillins, corticosteroids, antihistamines, antibiotics, anthralin, or tar preparations.

Claim 20

The phenyl-alpha-acyloxyacetamide of claim 12 wherein the compound is a member selected from the group consisting of: N-ethyl phenyl-alpha-acetoxyacetamide N-phenethyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-phenylacetoxyacetamide N-phenethyl phenyl-alpha-phenylacetoxyacetamide N-ethyl phenyl-alpha-benzoyloxyacetamide N-allyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-lauroyloxyacetamide N-phenethyl phenyl-alpha-linoleoyloxyacetamide N-phenethyl phenyl-alpha-linolenoyloxyacetamide N-isopropyl phenyl-alpha-acetoxyacetamide N-t-butyl phenyl-alpha-acetoxyacetamide N-p-chlorobenzyl phenyl-alpha-acetoxyacetamide N-p-methoxybenzyl phenyl-alpha-acetoxyacetamide N-p-methoxyphenethyl phenyl-alpha-acetoxyacetamide N-(3,4-dimethoxyphenethyl) phenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminoethyl) phenyl-alpha-acetoxyacetamide N-hydroxyethylthioethylphenyl-alpha-acetoxyacetamide N-(2-phenylethanol) phenyl-alpha-acetoxyacetamide N,N-dibenzyl phenyl-alpha-acetoxyacetamide N-hydroxyethoxyethyl phenyl-alpha-acetoxyacetamide N-diphenylmethyl phenyl-alpha-acetoxyacetamide N-p-fluorobenzyl phenyl-alpha-acetoxyacetamide N-p-methylbenzyl phenyl-alpha-acetoxyacetamide N-p-chlorophenethyl phenyl-alpha-acetoxyacetamide N-phenylpropyl phenyl-alpha-acetoxyacetamide N-phenylbutyl phenyl-alpha-acetoxyacetamide N-benzyl phenyl-alpha-acetoxyacetamide.

Claim 21

The phenyl-alpha-acyloxyacetamide of claim 12 wherein the compound is a member selected from the group consisting of: N-ethyl diphenyl-alpha-acetoxyacetamide N-phenethyl diphenyl-alpha-acetoxyacetamide N-ethyl diphenyl alpha-phenylacetoxyacetamide N-phenethyl diphenyl-alpha-phenylacetoxyacetamide N-isopropyl diphenyl alpha-acetoxyacetamide N-t-butyl diphenyl alpha-acetoxyacetamide N-benzyl diphenyl-alpha-acetoxyacetamide N-allyl diphenyl-alpha-acetoxyacetamide N,N-diethyl diphenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminoethyl) diphenyl-alpha-acetoxyacetamide N-P-chlorobenzyl diphenyl-alpha-acetoxy-acetamide N-P-methoxybenzyl diphenyl-alpha-acetoxy-acetamide N-P-methoxyphenethyl diphenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminopropyl) diphenyl-alpha-acetoxyacetamide N-(N',N'-dimethylamino propyl)diphenyl-alpha-acetoxyacetamide N-p-fluorobenzyl diphenyl-alpha-acetoxyacetamide N-p-methylbenzyl diphenyl-alpha-acetoxyacetamide N-p-chlorophenethyl diphenyl-alpha-acetoxyacetamide N-phenylpropyl diphenyl-alpha-acetoxyacetamide N-phenylbutyl diphenyl-alpha-acetoxyacetamide.

Claim 22

The method of claim 12 wherein the compound is a member selected from the group consisting of: N-ethyl phenyl-alpha-acetoxyacetamide N-phenethyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-phenylacetoxyacetamide N-phenethyl phenyl-alpha-phenylacetoxyacetamide N-ethyl phenyl-alpha-benzoyloxyacetamide N-allyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-lauroyloxyacetamide N-phenethyl phenyl-alpha-linoleoyloxyacetamide N-phenethyl phenyl-alpha-linolenoyloxyacetamide N-isopropyl phenyl-alpha-acetoxyacetamide N-t-butyl phenyl-alpha-acetoxyacetamide N-p-chlorobenzyl phenyl-alpha-acetoxyacetamide N-p-methoxybenzyl phenyl-alpha-acetoxyacetamide N-p-methoxyphenethyl phenyl-alpha-acetoxyacetamide N-(3,4-dimethoxyphenethyl) phenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminoethyl) phenyl-alpha-acetoxyacetamide N-hydroxyethylthioethylphenyl-alpha-acetoxyacetamide N-(2-phenylethanol) phenyl-alpha-acetoxyacetamide N,N-dibenzyl phenyl-alpha-acetoxyacetamide N-hydroxyethoxyethyl phenyl-alpha-acetoxyacetamide N-diphenylmethyl phenyl-alpha-acetoxyacetamide N-p-fluorobenzyl phenyl-alpha-acetoxyacetamide N-p-methylbenzyl phenyl-alpha-acetoxyacetamide N-p-chlorophenethyl phenyl-alpha-acetoxyacetamide N-phenylpropyl phenyl-alpha-acetoxyacetamide N-phenylbutyl phenyl-alpha-acetoxyacetamide N-benzyl phenyl-alpha-acetoxyacetamide.

Claim 23

The method of claim 12 wherein the compound is a member selected from the group consisting of: N-ethyl diphenyl-alpha-acetoxyacetamide N-phenethyl diphenyl-alpha-acetoxyacetamide N-ethyl diphenyl-alpha-phenylacetoxyacetamide N-phenethyl diphenyl-alpha-phenylacetoxyacetamide N-isopropyl diphenyl alpha-acetoxyacetamide N-t-butyl diphenyl alpha-acetoxyacetamide N-benzyl diphenyl-alpha-acetoxyacetamide N-allyl diphenyl-alpha-acetoxyacetamide N,N-diethyl diphenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminoethyl) diphenyl-alpha-acetoxyacetamide N-P-chlorobenzyl diphenyl-alpha-acetoxy-acetamide N-P-methoxybenzyl diphenyl-alpha-acetoxy-acetamide N-P-methoxyphenethyl diphenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminopropyl diphenyl-alpha-acetoxyacetamide N-(N',N'-dimethylamino propyl) diphenyl-alpha-acetoxyacetamide N-p-fluorobenzyl diphenyl-alpha-acetoxyacetamide N-p-methylbenzyl diphenyl-alpha-acetoxyacetamide N-p-chlorophenethyl diphenyl-alpha-acetoxyacetamide N-phenylpropyl diphenyl-alpha-acetoxyacetamide N-phenylbutyl diphenyl-alpha-acetoxyacetamide.

Claim 24

Method of treatment comprising administering an antipruritic or anti-inflammatory effect amount of a phenyl-alpha-hydroxyacetamide compound having the formula: ##STR7## wherein R 1 , R 2 =H, alkyl or aralkyl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms, R 3 =H, aklyk, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms, and the hydrogen atom of the phenyl, R 1 , R 2 or R 3 may be substituted by a nonfunctional halogen or a radical such as a lower alkyl or alkoxy having 1 to 9 carbon atoms; and the carbon atom of R or R 2 may be substituted by a nonfunctional N, S or O; provided that both R 1 and R 2 are not N,N-diethyl, N,N-dipropyl, or N,N-dibutyl when R 3 =CH 3 and R 4 =H, and R 1 is not ethyl or isopropyl when R 2 is H and R 3 is phenyl in a pharmaceutically acceptable vehicle for topical application to involved body areas or internal administration.

Claim 25

Method of treatment comprising administering an antipruritic or anti-inflammatory effect amount of a phenyl-alpha-hydroxyacetamide compound having the formula: ##STR7## wherein R 1 , R 2 =H, alkyl or aralkyl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms, R 3 =H, aklyk, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 25 carbon atoms, and the hydrogen atom of the phenyl, R 1 , R 2 or R 3 may be substituted by a nonfunctional halogen or a radical such as a lower alkyl or alkoxy having 1 to 9 carbon atoms; and the carbon atom of R or R 2 may be substituted by a nonfunctional N, S or O; provided that both R 1 and R 2 are not N,N-diethyl, N,N-dipropyl, or N,N-dibutyl when R 3 =CH 3 and R 4 =H, and R 1 is not ethyl or isopropyl when R 2 is H and R 3 is phenyl in a pharmaceutically acceptable vehicle for topical application to involved body areas or internal administration.

Claim 26

The phenyl-alpha-hydroxyacetamide of claim 18 wherein the compound is a member selected from the group consisting of: N-ethyl phenyl-alpha-hydroxyacetamide N-phenethyl phenyl-alpha-hydroxyacetamide N-benzyl phenyl-alpha-hydroxyacetamide N,N-diethyl phenyl-alpha-hydroxyacetamide N-P-chlorobenzyl phenyl-alpha-hydroxyacetamide N-P-fluorobenzyl phenyl-alpha-hydroxyacetamide N-phenethyl diphenyl-alpha-hydroxyacetamide N-benzyl diphenyl-alpha-hydroxyacetamide N-P-chlorobenzyl diphenyl-alpha-hydroxyacetamide N,N-diethyl diphenyl-alpha-hydroxyacetamide N-(N',N'-diethylaminoethyl) diphenyl-alpha-hydroxyacetamide N-p-fluorobenzyl diphenyl-alpha-hydroxyacetamide N-isopropyl phenyl-alpha-hydroxyacetamide N-t-butyl phenyl-alpha-hydroxyacetamide N-(N',N'-diethylaminoethyl) phenyl-alpha-hydroxyacetamide N-allyl phenyl-alpha-hydroxyacetamide N-P-methoxybenzyl phenyl-alpha-hydroxyacetamide N-P-methoxyphenethyl phenyl-alpha-hydroxyacetamide N-(3,4-dimethoxyphenethyl) phenyl-alpha-hydroxyacetamide N-hydroxyethylthioethyl phenyl-alpha-hydroxyacetamide N-(N',N'-diethylaminopropyl) phenyl-alpha-hydroxyacetamide N-(N',N'-dimethylaminopropyl) phenyl-alpha-hydroxy-acetamide N-(N',N'-diethylaminopropyl) diphenyl-alpha-hydroxyacetamide N-(N',N'-dimethylaminopropyl) diphenyl-alpha-hydroxyacetamide N-P-methoxybenzyl diphenyl-alpha-hydroxyacetamide N-P-methoxyphenethyl diphenyl-alpha-hydroxyacetamide N-(3,4-dimethoxyphenethyl) diphenyl-alpha-hydroxy-acetamide N-hydroxyethylthioethyl diphenyl-alpha-hydroxy-acetamide N-t-butyl diphenyl-alpha-hydroxyacetamide N-allyl diphenyl-alpha-hydroxyacetamide.

Claim 27

A phenyl-alpha-acyloxyacetamide compound selected from the group consisting of: N-ethyl phenyl-alpha-acetoxyacetamide N-phenethyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-phenylacetoxyacetamide N-phenethyl phenyl-alpha-phenylacetoxyacetamide N-ethyl phenyl-alpha-benzoyloxyacetamide N-allyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-lauroyloxyacetamide N-phenethyl phenyl-alpha-linoleoyloxyacetamide N-phenethyl phenyl-alpha-linolenoyloxyacetamide N-isopropyl phenyl-alpha-acetoxyacetamide N-t-butyl phenyl-alpha-acetoxyacetamide N-p-chlorobenzyl phenyl-alpha-acetoxyacetamide N-p-methoxybenzyl phenyl-alpha-acetoxyacetamide N-p-methoxyphenylethyl phenyl-alpha-acetoxyacetamide N-(3,4-dimethoxyphenethyl) phenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminoethyl) phenyl-alpha-acetoxyacetamide N-hydroxyethylthioethylphenyl-alpha-acetoxyacetamide N-(2-phenylethanol) phenyl-alpha-acetoxyacetamide N,N-dibenzyl phenyl-alpha-acetoxyacetamide N-hydroxyethoxyethyl phenyl-alpha-acetoxyacetamide N-diphenylmethyl phenyl-alpha-acetoxyacetamide N-p-fluorobenzyl phenyl-alpha-acetoxyacetamide N-p-methylbenzyl phenyl-alpha-acetoxyacetamide N-p-chlorophenethyl phenyl-alpha-acetoxyacetamide N-phenylpropyl phenyl-alpha-acetoxyacetamide N-phenylbutyl phenyl-alpha-acyloxyacetamide; and N-benzyl phenyl-alpha-acetoxyacetamide.

Claim 28

A phenyl-alpha-acyloxyacetamide compound selected from the group consisting of: N-ethyl phenyl-alpha-acetoxyacetamide N-phenethyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-phenylacetoxyacetamide N-phenethyl phenyl-alpha-phenylacetoxyacetamide N-ethyl phenyl-alpha-benzoyloxyacetamide N-allyl phenyl-alpha-acetoxyacetamide N-ethyl phenyl-alpha-lauroyloxyacetamide N-phenethyl phenyl-alpha-linoleoyloxyacetamide N-phenethyl phenyl-alpha-linolenoyloxyacetamide N-isopropyl phenyl-alpha-acetoxyacetamide N-t-butyl phenyl-alpha-acetoxyacetamide N-p-chlorobenzyl phenyl-alpha-acetoxyacetamide N-p-methoxybenzyl phenyl-alpha-acetoxyacetamide N-p-methoxyphenylethyl phenyl-alpha-acetoxyacetamide N-(3,4-dimethoxyphenethyl) phenyl-alpha-acetoxyacetamide N-(N',N'-diethylaminoethyl) phenyl-alpha-acetoxyacetamide N-hydroxyethylthioethylphenyl-alpha-acetoxyacetamide N-(2-phenylethanol) phenyl-alpha-acetoxyacetamide N,N-dibenzyl phenyl-alpha-acetoxyacetamide N-hydroxyethoxyethyl phenyl-alpha-acetoxyacetamide N-diphenylmethyl phenyl-alpha-acetoxyacetamide N-p-fluorobenzyl phenyl-alpha-acetoxyacetamide N-p-methylbenzyl phenyl-alpha-acetoxyacetamide N-p-chlorophenethyl phenyl-alpha-acetoxyacetamide N-phenylpropyl phenyl-alpha-acetoxyacetamide N-phenylbutyl phenyl-alpha-acyloxyacetamide; and N-benzyl phenyl-alpha-acetoxyacetamide.

Claim 29

A diphenyl-alpha-acyloxyacetamide compound selected from the group consisting of: N-ethyl diphenyl-alpha-acetoxyacetamide N-phenethyl diphenyl-alpha-acetoxyacetamide N-ethyl diphenyl-alpha-phenylacetoxyacetamide N-phenethyl diphenyl-alpha-phenylacetoxyacetamide N-isopropyl diphenyl alpha-acetoxyacetamide N-t-butyl diphenyl alpha-acetoxyacetamide N-benzyl diphenyl-alpha-acetoxyacetamide N-allyl diphenyl-alpha-acetoxyacetamide N,N-diethyl diphenyl-alpha-acetoxyacetamide; N-(N',N'-diethylaminoethyl) diphenyl-alpha-acetoxyacetamide.

Claim 30

A diphenyl-alpha-acyloxyacetamide compound selected from the group consisting of: N-ethyl diphenyl-alpha-acetoxyacetamide N-phenethyl diphenyl-alpha-acetoxyacetamide N-ethyl diphenyl-alpha-phenylacetoxyacetamide N-phenethyl diphenyl-alpha-phenylacetoxyacetamide N-isopropyl diphenyl alpha-acetoxyacetamide N-t-butyl diphenyl alpha-acetoxyacetamide N-benzyl diphenyl-alpha-acetoxyacetamide N-allyl diphenyl-alpha-acetoxyacetamide N,N-diethyl diphenyl-alpha-acetoxyacetamide; N-(N',N'-diethylaminoethyl) diphenyl-alpha-acetoxyacetamide.