US4517329A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymeric antitumor agent
Assignee: Monsanto Co
•
Filing: 1983-10-07
•
Granted: 1985-05-14
•
Expires: 2003-10-07
Abstract
Abstract The disclosure relates to pharmaceutically acceptable amide and imide derivatives of low molecular weight copolymers of chloroethyl vinyl ether and maleic anhydride having antitumor activity.
Inventors
- 👤 Edward H. Mottus
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 15:33
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K31/785
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
78 words
An antitumor active, water-soluble composition of matter selected from the group consisting of low molecular weight copolymers of chloroethyl vinyl ether and maleic anhydride, wherein said molecular weight is less than about 3000 and wherein said copolymer is derivatized to contain half-amide, half-carboxyl acid groups in which from 0 weight percent to about 25 weight percent of the half-amide, half-carboxyl acid groups are converted to imide groups, and the pharmaceutically acceptable cationic salt derivatives of said derivatized copolymers.
Claim 2
Dependent Claim
78 words
An antitumor active, water-soluble composition of matter selected from the group consisting of low molecular weight copolymers of chloroethyl vinyl ether and maleic anhydride, wherein said molecular weight is less than about 3000 and wherein said copolymer is derivatized to contain half-amide, half-carboxyl acid groups in which from 0 weight percent to about 25 weight percent of the half-amide, half-carboxyl acid groups are converted to imide groups, and the pharmaceutically acceptable cationic salt derivatives of said derivatized copolymers.
Claim 3
Dependent Claim
19 words
The composition of matter of claim 1 in which the derivatized groups are half-amide, half-ammonium salt and imide groups.
Claim 4
Dependent Claim
17 words
The composition of matter of claim 1 in which the derivatized groups are half-amide, half-ammonium salt groups.
Claim 5
Dependent Claim
28 words
A pharmaceutical composition having antitumor activity which comprises, as active ingredient, the copolymer derivative of claim 1, in association with a significant amount of a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
28 words
A pharmaceutical composition having antitumore activity which comprises, as active ingredient, the copolymer derivative of claim 2, in association with a significant amount of a pharmaceutically acceptable carrier.
Claim 7
Dependent Claim
28 words
A pharmaceutical composition having antitumor activity which comprises, as active ingredient, the copolymer derivative of claim 3, in association with a significant amount of a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
37 words
A pharmaceutical composition for parenteral administration and useful for the treatment of tumors which comprises, as active ingredient, the copolymer composition of claim 1, in association with a significant amount of a sterile injectable pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
37 words
A pharmaceutical composition for parenteral administration and useful for the treatment of tumors which comprises, as active ingredient, the copolymer composition of claim 2, in association with a significant amount of a sterile injectable pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
37 words
A pharmaceutical composition for parenteral administration and useful for the treatment of tumors which comprises, as active ingredient, the copolymer composition of claim 3, in association with a significant amount of a sterile injectable pharmaceutically acceptable carrier.
References Cited (Backward Citations)
CA664322A
Cited
US2313565A
Cited
US2944033A
Cited
US3157595A
Cited
US3275611A
Cited
US3224943A
Cited
US3794622A
Cited
US3998907A
Cited
US4255537A
Cited
US4309413A
Cited
US4397995A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-05-13 | 1988-11-12 | 1989-05-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-05-13 | 1992-11-12 | 1993-05-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-05-13 | 1996-11-12 | 1997-05-14 | $7700.00 | Window Closed / Lapsed |