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US4515718A
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Amidinoureas
Assignee: William H Rorer Inc
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Filing: 1982-09-30
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Granted: 1985-05-07
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Expires: 2002-09-30
Abstract
Abstract A novel method of treating gastrointestinal, spasmolytic and ulcerogenic disorders by the administration of amidinoureas is disclosed.
Inventors
- 👤 Julius Diamond
- 👤 George H. Douglas
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:42
CPC Classifications
C; C07; C07D; C07D221/00; C07D223/00; C07D223/02
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
126 words
An amidinourea compound of the formula I or its tautomeric form II when R is hydrogen: ##STR2## where: R 2 , R 3 , R 4 , R 5 and R 6 may be the same or different and are hydrogen, halo, loweralkyl, haloloweralkyl, nitro, loweralkoxy, hydroxy, cyano, haloloweralkoxy, or loweralkylsulfonyl, provided at least three of R 2 , R 3 , R 4 , R 5 and R 6 are hydrogen; R and R' are hydrogen or loweralkyl; R" and R'" together with nitrogen form a 5-7 atom ring consisting of 3-6 carbon atoms and 1-2 nitrogen atoms; R n is hydrogen or loweralkyl provided at least one of R, R', R" and R'" is other than hydrogen; and the non-toxic acid addition salts thereof.
Claim 2
Dependent Claim
126 words
An amidinourea compound of the formula I or its tautomeric form II when R is hydrogen: ##STR2## where: R 2 , R 3 , R 4 , R 5 and R 6 may be the same or different and are hydrogen, halo, loweralkyl, haloloweralkyl, nitro, loweralkoxy, hydroxy, cyano, haloloweralkoxy, or loweralkylsulfonyl, provided at least three of R 2 , R 3 , R 4 , R 5 and R 6 are hydrogen; R and R' are hydrogen or loweralkyl; R" and R'" together with nitrogen form a 5-7 atom ring consisting of 3-6 carbon atoms and 1-2 nitrogen atoms; R n is hydrogen or loweralkyl provided at least one of R, R', R" and R'" is other than hydrogen; and the non-toxic acid addition salts thereof.
Claim 3
Dependent Claim
10 words
An amidinourea compound according to claim 1 which is 1-[N,N-(N-methyl-3'-azapentamethylene)amidino]-3-(2,6-dimethylphenyl)urea.
Claim 4
Dependent Claim
10 words
An amidinourea compound according to claim 1 which is 1-[N,N-(N-methyl-3'-azaheptamethylene)amidino]-3-(2,6-dimethylphenyl)urea.
References Cited (Backward Citations)
US3830839A
Cited
US3903084A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-05-06 | 1988-11-05 | 1989-05-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-05-06 | 1992-11-05 | 1993-05-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-05-06 | 1996-11-05 | 1997-05-07 | $7700.00 | Window Closed / Lapsed |