US4512987A
Expired / Lapsed
US
⏱️ 0.0 years remaining
New pharmaceutical preparations
Assignee: Novartis Corp
•
Filing: 1982-10-13
•
Granted: 1985-04-23
•
Expires: 2002-10-13
Abstract
Abstract The invention concerns new pharmaceutical preparations for topical administration, such as creams, ointments, foams, pastes or gels, which contain the anti-inflammatorily active glucocorticoid 2-chloro-6α,9α-difluoro-16α-methyl-11β,17α,21-trihydroxy-pregna-1,4-diene-3,20-dione (2-chloroflumethasone, halometasone) and the antimicrobial agent 2,4,4'-trichloro-2'-hydroxy-diphenyl ether (triclosan). The new dermatics may contain, besides these two components, pharmaceutical carriers as usually present in formulations for topical administration. The new dermatics are especially suitable for the treatment of inflected forms of acute eczematous dermatoses of different origin, for the initial treatment of strongly inflamed dermatomycoses or strongly inflamed forms of pyodermias.
Inventors
- 👤 Ctibor Schindlery
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 01:58
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/57; A61P; A61P29/00; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
47 words
A pharmaceutical preparation for topical administration which contains the corticoid, 2-chloro-6α,9α-difluoro-16α-methyl 11β, 17α, 21-trihydroxy-pregna-1,4-diene-3,20-dione, and the antimicrobial agent, 2,4,4'-trichloro-2'-hydroxy-diphenyl ether, said preparation containing in the range of from about 0.01% to about 2.5% of said corticoid and from about 0.1% to about 5% of said antimicrobial agent.
Claim 2
Dependent Claim
47 words
A pharmaceutical preparation for topical administration which contains the corticoid, 2-chloro-6α,9α-difluoro-16α-methyl 11β, 17α, 21-trihydroxy-pregna-1,4-diene-3,20-dione, and the antimicrobial agent, 2,4,4'-trichloro-2'-hydroxy-diphenyl ether, said preparation containing in the range of from about 0.01% to about 2.5% of said corticoid and from about 0.1% to about 5% of said antimicrobial agent.
Claim 3
Dependent Claim
31 words
A pharmaceutical preparation according to claim 1, containing in the range of about 0.02% to about 0.8% of said corticoid and from about 0.5% to about 3% of said antimicrobial agent.
Claim 4
Dependent Claim
18 words
Pharmaceutical preparation as claimed in claim 1 in the form of a cream, ointment, paste, foam or gel.
Claim 5
Dependent Claim
13 words
A pharmaceutical preparation according to claim 1 in the form of a cream.
Claim 6
Dependent Claim
13 words
A pharmaceutical preparation according to claim 2 in the form of a cream.
Claim 7
Dependent Claim
31 words
A pharmaceutical preparation according to claim 1, containing in the range of about 0.03% to about 0.1% of said corticoid and from about 0.7% to about 2% of said antimicrobial agent.
Claim 8
Dependent Claim
23 words
A pharmaceutical preparation according to claim 5, having a content of about 0.05% of said corticoid and about 1% of said antimicrobial agent.
Claim 9
Dependent Claim
56 words
A method of treatment of infected or infection prone: acute contact dermatitus, acute endogenous eczema, acute nummular eczema, acute seborrhoeic eczema, impetigo contagiosa, ostiofolliculitis, inflamed folliculitis barbae, ecthyma, intertrigo, erythrasma or acute inflamed superficial dermatomycoses, comprising administering an effective amount of a pharmaceutical composition according to claim 1 to a patient in need of the same.
Claim 10
Dependent Claim
18 words
A method of treatment of infected dermatoses consisting in administering a pharmaceutical preparation as claimed in claim 1.
Claim 11
Dependent Claim
30 words
A method of treatment of infected acute eczematous dermatoses of different origin, for the initial treatment of strongly inflamed forms of pyodermia or strong inflamed dermatomycosis according to claim 9.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-04-22 | 1988-10-22 | 1989-04-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-04-22 | 1992-10-22 | 1993-04-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-04-22 | 1996-10-22 | 1997-04-23 | $7700.00 | Window Closed / Lapsed |