US4505897A
Expired / Lapsed
US
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Cyclic pentapeptides displaying somatostatin antagonism and method of treatment of mammals therewith
Assignee: Tulane University
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Filing: 1983-06-06
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Granted: 1985-03-19
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Expires: 2003-06-06
Abstract
Abstract Novel cyclic pentapeptide somatostatin antagonists and method for increasing the release of growth hormone, insulin, and glucagon in mammals are described.
Inventors
- 👤 David H. Coy
- 👤 William A. Murphy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 02:32
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/655; C07K14/6555; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/16
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
35 words
A cyclic pentapeptide compound having the structural formula: ##STR9## wherein X is phenylalanyl; Y is D-tryptophyl; Z is lysyl; Thr is threonyl; and R 1 is hydrogen or benzyl; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
35 words
A cyclic pentapeptide compound having the structural formula: ##STR9## wherein X is phenylalanyl; Y is D-tryptophyl; Z is lysyl; Thr is threonyl; and R 1 is hydrogen or benzyl; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
7 words
A compound according to claim 1, cyclo[Pro-Phe-D-Trp-Lys-Thr(Bzl)].
Claim 4
Dependent Claim
7 words
A compound according to claim 1, cyclo(Pro-Phe-D-Trp-Lys-Thr).
Claim 5
Independent Claim
56 words
A method for increasing release of growth hormone, insulin and glucagon in mammals, said method comprising: administering thereto from 0.00001 to 1 mg/kg of mammalian body weight/day of a compound having the structural formula, ##STR10## wherein X is phenylalanyl; Y is D-tryptophyl; Z is lysyl; R 1 is hydrogen or benzyl; or pharmaceutically acceptable salts thereof.
Claim 6
Independent Claim
56 words
A method for increasing release of growth hormone, insulin and glucagon in mammals, said method comprising: administering thereto from 0.00001 to 1 mg/kg of mammalian body weight/day of a compound having the structural formula, ##STR10## wherein X is phenylalanyl; Y is D-tryptophyl; Z is lysyl; R 1 is hydrogen or benzyl; or pharmaceutically acceptable salts thereof.
Claim 7
Dependent Claim
22 words
A method according to claim 4 for releasing growth hormone in mammals wherein the compound administered to said mammalian host is cyclo[Pro-Phe-D-Trp-Lys-Thr(Bzl)].
Claim 8
Dependent Claim
22 words
A method according to claim 4 for releasing growth hormone in mammals wherein the compound administered to said mammalian host is cyclo(Pro-Phe-D-Trp-Lys-Thr).
Claim 9
Dependent Claim
21 words
A method according to claim 4 for releasing insulin in mammals wherein the compound administered to said mammalian host is cyclo[Pro-Phe-D-Trp-Lys-Thr(Bzl)].
Claim 10
Dependent Claim
21 words
A method according to claim 4 for releasing insulin in mammals wherein the compound administered to said mammalian host is cyclo(Pro-Phe-D-Trp-Lys-Thr).
Claim 11
Dependent Claim
21 words
A method according to claim 4 for releasing glucagon in mammals wherein the compound administered to said mammalian host is cyclo[Pro-Phe-D-Trp-Lys-Thr(Bzl)].
Claim 12
Dependent Claim
21 words
A method according to claim 4 for releasing glucagon in mammals wherein the compound administered to said mammalian host is cyclo(Pro-Phe-D-Trp-Lys-Thr).
References Cited (Backward Citations)
US4235886A
Cited
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| 3.5 Years (Year 4) | 1988-03-18 | 1988-09-17 | 1989-03-19 | $2000.00 | Window Closed / Lapsed |
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