US4500529A
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Method of treating cardiac disorders with N-(aryloxyalkyl)-N'-(aminoalkyl)ureas
Assignee: AHP Subsidiary 9 Corp
•
Filing: 1983-05-09
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Granted: 1985-02-19
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Expires: 2003-05-09
Abstract
Abstract N-(Aryloxyalkyl)-N'-(aminoalkyl)ureas and thioureas having the formula: <IMAGE> wherein R1 and R2 are hydrogen, loweralkyl, cycloalkyl, phenyl or phenyllower alkyl, and R3 and R4 are hydrogen, loweralkyl, phenyl and phenylalkyl or R3 and R4 taken together with the adjacent nitrogen form a heterocyclic residue are disclosed in a method of suppressing cardiac arrhythmias.
Inventors
- 👤 James R. Shanklin, Jr.
- 👤 Christopher P. Johnson, III
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 05:31
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; C07C; C07C275/00; C07C275/04; C07C275/06; C07C275/14; C07C335/00; C07C335/04; C07C335/06; C07C335/08; C07C43/00; C07C43/02; C07C43/20; C07C43/225; C07D295/00; C07D295/04; C07D295/12; C07D295/125; C07D295/13
Claims Analysis
Total Claims: 74
Claim 1
Independent Claim
209 words
A method for treating cardiac arrhythmia in an animal which comprises administering to said animal an effective amount of a compound having the formula: ##STR9## wherein; Ar is 1 and 2-naphthyl, 2,3-dihydro-1H-inden-4(or 5)yl, 3-pyridinyl, phenyl or phenyl substituted by 1-3 radicals which may be the same or different selected from the group consisting of loweralkyl, loweralkoxy, halogen, trifluoromethyl, amino, cyano, aminocarbonyl, nitro, loweralkylthio, loweralkylsulfinyl, loweralkylsulfonyl, loweralkanoyl, benzoylamino or loweralkanoylamino; R 1 and R 2 are selected from the group consisting of hydrogen, loweralkyl, cycloalkyl containing 3 to 9 carbon atoms, phenyl, phenyl substituted by halogen, loweralkyl or loweralkoxy, or phenyl-loweralkyl wherein phenyl may also be substituted by halogen, loweralkyl or loweralkoxy; X is selected from oxygen or sulfur; R 3 and R 4 are selected from the group consisting of hydrogen, loweralkyl, phenyl and phenyl-loweralkyl and may be the same or different or R 3 and R 4 taken together with the adjacent nitrogen form a heterocyclic residue selected from the group consisting of pyrrolidino, piperidino, 4-phenylpiperidino, 2,6-loweralkyl-piperidino, 4-hydroxy-4-phenylpiperidino, 4-cyano-4-phenylpiperidino, 4-phenyl-1,2,3,6-tetrahydropyridino, piperazino, 4-loweralkylpiperazino, 4-phenyl-piperazino, 4-phenylloweralkylpiperazino or morpholino radicals; alk 1 and alk 2 are selected from the group consisting of loweralkylene or loweralkylene-loweralkyl and may be the same or different, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 2
Independent Claim
209 words
A method for treating cardiac arrhythmia in an animal which comprises administering to said animal an effective amount of a compound having the formula: ##STR9## wherein; Ar is 1 and 2-naphthyl, 2,3-dihydro-1H-inden-4(or 5)yl, 3-pyridinyl, phenyl or phenyl substituted by 1-3 radicals which may be the same or different selected from the group consisting of loweralkyl, loweralkoxy, halogen, trifluoromethyl, amino, cyano, aminocarbonyl, nitro, loweralkylthio, loweralkylsulfinyl, loweralkylsulfonyl, loweralkanoyl, benzoylamino or loweralkanoylamino; R 1 and R 2 are selected from the group consisting of hydrogen, loweralkyl, cycloalkyl containing 3 to 9 carbon atoms, phenyl, phenyl substituted by halogen, loweralkyl or loweralkoxy, or phenyl-loweralkyl wherein phenyl may also be substituted by halogen, loweralkyl or loweralkoxy; X is selected from oxygen or sulfur; R 3 and R 4 are selected from the group consisting of hydrogen, loweralkyl, phenyl and phenyl-loweralkyl and may be the same or different or R 3 and R 4 taken together with the adjacent nitrogen form a heterocyclic residue selected from the group consisting of pyrrolidino, piperidino, 4-phenylpiperidino, 2,6-loweralkyl-piperidino, 4-hydroxy-4-phenylpiperidino, 4-cyano-4-phenylpiperidino, 4-phenyl-1,2,3,6-tetrahydropyridino, piperazino, 4-loweralkylpiperazino, 4-phenyl-piperazino, 4-phenylloweralkylpiperazino or morpholino radicals; alk 1 and alk 2 are selected from the group consisting of loweralkylene or loweralkylene-loweralkyl and may be the same or different, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,4-dichlorophenoxy)ethyl]-N'-[2-dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 4
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 5
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,4-dichlorophenoxy)ethyl]-N'-[3-(dimethylamino)propyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 6
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[3-(3,5-dichlorophenoxy)propyl]-N'-[2-(dimethylamino)ethyl]N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 7
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)-N-(2-phenoxyethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 8
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[3-(3,5-dichlorophenoxy)propyl]-N'-[3-(dimethylamino)propyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 9
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[3-dimethylamino)propyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 10
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N-(1-methylethyl)-N'-[2-[bis(1-methylethyl)amino]ethyl]urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 11
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-[2-(3,4-dimethylphenoxy)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 12
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(2,4-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 13
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-phenylurea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 14
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)-N-[2-(1-naphthalenyloxy)ethyl]urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 15
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3-chlorophenoxy)ethyl]-N'-[2-dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 16
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(2,6-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 17
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-dimethylamino)ethyl]-N'-methyl-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 18
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 19
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'[2-(dimethylamino)ethyl]-N-[2-(3,5-dimethylphenoxy)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 20
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dimethoxyphenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 21
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-[2-(3,4-dimethylphenoxy)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 22
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3-chlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 23
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(2,5-dichlorophenoxyethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 24
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N-(1-methylethyl)-N'-[2-(4-morpholinyl)ethyl]urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 25
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)-N-[2-(3-trifluoromethylphenoxy)ethyl]urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 26
Dependent Claim
20 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-methyl urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 27
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-[2-(3-fluorophenoxy)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 28
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(2,3-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 29
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(2-chlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 30
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)-N-[2-(2-naphthalenyloxy)ethyl]urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 31
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-[2-[(2,3-dihydro-1H-inden-5-yl)oxy]ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 32
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-[2-[(2,3-dihydro-1H-inden-4-yl)oxy]ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 33
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N'-methyl-N'-[2-(methylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 34
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-[(2,3-dihydro-1H-inden-4-yl)oxy]ethyl]-N-[2-(methylamino)ethyl]-N-methylurea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 35
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-n-butyl-N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 36
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy]ethyl]-N'-[2-(dimethylamino)ethyl]-N-propylurea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 37
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-cyclohexyl-N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 38
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(2-methylpropyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 39
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(3,5-dichlorophenoxy)ethyl]-N-[2-(dimethylamino)ethyl]-N-methylurea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 40
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N-(1-methylethyl)-N'-(2-aminoethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 41
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(diethylamino)ethyl]-N-methyl-N-(2-phenoxyethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 42
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-methyl-N-(2-phenoxyethyl)-N'-[2-(1-pyrrolidinyl)ethyl]urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 43
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-(diethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 44
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)thiourea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 45
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(diethylamino)ethyl]-N-(1-methylethyl)-N-(2-phenoxyethyl)thiourea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 46
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)-N-[2-(1-naphthalenyloxy)ethyl]thiourea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 47
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-methyl-N-(2-phenoxyethyl)thiourea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 48
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-[(3,5-dichlorophenyl)oxy]ethyl]-N-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 49
Dependent Claim
17 words
The method of claim 1 wherein the compound is N'-[2-[2,3-dihydro-1H-inden-4-yl)oxy]ethyl]-N-[2-(dimethylamino]ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt thereof.
Claim 50
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-[2-(2,6-dimethylphenoxy)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 51
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(diethylamino)ethyl]-N-(1-methylethyl)-N-[2-[4-(methylsulfonyl)phenoxy]ethyl]urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 52
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)-N-[2-(4-nitrophenoxy)ethyl]urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 53
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)-N-[2-[4-(methylsulfonyl)phenoxy]ethyl]urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 54
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(diethylamino)ethyl]-N-[2-(4-fluorophenoxy)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 55
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(dimethylamino)ethyl]-N-[2-(4-fluorophenoxy)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 56
Dependent Claim
19 words
The method of claim 1 wherein the compound is N-[2-(2-cyanophenoxy)ethyl]-N'-[2-(diethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 57
Dependent Claim
19 words
The method of claim 1 wherein the compound is N'-[2-(diethylamino)ethyl]-N-methyl-N-(2-phenoxyethyl)thiourea or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 58
Dependent Claim
34 words
A therapeutic composition having cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 59
Dependent Claim
34 words
A therapeutic composition having cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 60
Dependent Claim
19 words
A composition of claim 57 wherein the compound is N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof.
Claim 61
Dependent Claim
34 words
A therapeutic composition having cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N-[2-(3,4-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-(1-methylethyl)urea or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 62
Dependent Claim
34 words
A therapeutic composition having cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N-[2-(3,4-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-(1-methylethyl)urea or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 63
Dependent Claim
34 words
A therapeutic composition having cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)-N-[2-(1-naphthyleneoxy)ethyl]urea or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 64
Dependent Claim
34 words
A therapeutic composition having cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)-N-[2-(1-naphthyleneoxy)ethyl]urea or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 65
Dependent Claim
34 words
A therapeutic composition having cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N'-[2-(dimethylamino)ethyl]-N-[2-(3,4-dimethylphenoxy)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 66
Dependent Claim
34 words
A therapeutic composition having cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N'-[2-(dimethylamino)ethyl]-N-[2-(3,4-dimethylphenoxy)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 67
Dependent Claim
34 words
A therapeutic composition having cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N-[2-(4-chlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 68
Dependent Claim
34 words
A therapeutic composition having cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N-[2-(4-chlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 69
Dependent Claim
34 words
A therapeutic composition having cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N-[2-(2,3-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 70
Dependent Claim
34 words
A therapeutic composition having cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N-[2-(2,3-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea, or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 71
Dependent Claim
35 words
A therapeutic composition having a cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N'-[2-(dimethylamino)ethyl]-N-[2-(2,3-dihydro-1H-inden-4-yl)oxy]ethyl]-N-(1-methylethyl)urea or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 72
Dependent Claim
35 words
A therapeutic composition having a cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N'-[2-(dimethylamino)ethyl]-N-[2-(2,3-dihydro-1H-inden-4-yl)oxy]ethyl]-N-(1-methylethyl)urea or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 73
Dependent Claim
35 words
A therapeutic composition having a cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N'-[2-(diethylamino)ethyl]-N-(1-methylethyl)-N-(2-phenoxyethyl)thiourea, or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
Claim 74
Dependent Claim
35 words
A therapeutic composition having a cardiac arrhythmic inhibiting activity comprising (a) an effective amount of a compound selected from N'-[2-(diethylamino)ethyl]-N-(1-methylethyl)-N-(2-phenoxyethyl)thiourea, or a pharmaceutically acceptable addition salt or hydrate thereof, and (b) a pharmaceutical carrier therefor.
References Cited (Backward Citations)
DE2801187A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-19 | 1988-08-20 | 1989-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-19 | 1992-08-20 | 1993-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-19 | 1996-08-20 | 1997-02-19 | $7700.00 | Window Closed / Lapsed |