US4500508A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Radionuclide labeled lymphocytes for therapeutic use
Assignee: United States, ENERGY THE, Secretary of, Department of
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Filing: 1983-05-03
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Granted: 1985-02-19
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Expires: 2003-05-03
Abstract
Abstract Lymphocytes labelled with beta -emitting radionuclides are therapeutically useful, particularly for lymphoid ablation. They are prepared by incubation of the lymphocytes with the selected radionuclide-oxine complex.
Inventors
- 👤 Suresh C. Srivastava
- 👤 Rashid A. Fawwaz
- 👤 Powell Richards
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 05:01
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1203; A61K2121/00
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
30 words
Lymphocytes labeled with a therapeutically effective amount of a β-emitting radionuclide selected from the group consisting of 109 Pd, 67 Cu, 66 Ni, 55 Co, 69 Zn and 90 Y.
Claim 2
Dependent Claim
30 words
Lymphocytes labeled with a therapeutically effective amount of a β-emitting radionuclide selected from the group consisting of 109 Pd, 67 Cu, 66 Ni, 55 Co, 69 Zn and 90 Y.
Claim 3
Dependent Claim
13 words
A labeled lymphocyte as in claim 1 wherein the label is 109 Pd.
Claim 4
Dependent Claim
13 words
A labeled lymphocyte as in claim 1 wherein the label is 67 Cu.
Claim 5
Dependent Claim
13 words
A labeled lymphocyte as in claim 1 wherein the label is 66 Ni.
Claim 6
Dependent Claim
13 words
A labeled lymphocyte as in claim 1 wherein the label is 55 Co.
Claim 7
Dependent Claim
13 words
A labeled lymphocyte as in claim 1 wherein the label is 69 Zn.
Claim 8
Dependent Claim
13 words
A labeled lymphocyte as in claim 1 wherein the label is 90 Y.
Claim 9
Independent Claim
52 words
A method of effecting lymphoid ablation in order to prevent the rejection of allografts which comprises parenteral administration of a therapeutically effective amount of syngeneic or allogeneic lymphocytes labeled with a β-emitting radionuclide selected from the group consisting of 109 Pd, 67 Cu, 66 Ni, 55 Co, 69 Zn and 90 Y.
Claim 10
Independent Claim
52 words
A method of effecting lymphoid ablation in order to prevent the rejection of allografts which comprises parenteral administration of a therapeutically effective amount of syngeneic or allogeneic lymphocytes labeled with a β-emitting radionuclide selected from the group consisting of 109 Pd, 67 Cu, 66 Ni, 55 Co, 69 Zn and 90 Y.
Claim 11
Dependent Claim
12 words
A method as in claim 8 wherein the label is 109 Pd.
Claim 12
Dependent Claim
12 words
A method as in claim 8 wherein the label is 67 Cu.
Claim 13
Dependent Claim
12 words
A method as in claim 8 wherein the label is 66 Ni.
Claim 14
Dependent Claim
12 words
A method as in claim 8 wherein the label is 55 Co.
Claim 15
Dependent Claim
12 words
A method as in claim 8 wherein the label is 69 Zn.
Claim 16
Dependent Claim
12 words
A method as in claim 8 wherein the label is 90 Y.
Claim 17
Independent Claim
56 words
A method of effecting lymphoid ablation in order to prevent the rejection of allografts which comprises parenteral administration of a therapeutically effective amount of syngeneic or allogeneic lymphocytes labeled with a β-emitting radionuclide selected from the group consisting of 109 Pd, 67 Cu, 66 Ni, 55 Co, 69 Zn and 90 Y together with anti-lymphocyte globulin.
Claim 18
Independent Claim
56 words
A method of effecting lymphoid ablation in order to prevent the rejection of allografts which comprises parenteral administration of a therapeutically effective amount of syngeneic or allogeneic lymphocytes labeled with a β-emitting radionuclide selected from the group consisting of 109 Pd, 67 Cu, 66 Ni, 55 Co, 69 Zn and 90 Y together with anti-lymphocyte globulin.
Claim 19
Dependent Claim
12 words
A method as in claim 15 wherein the label is 109 Pd.
Claim 20
Dependent Claim
12 words
A method as in claim 15 wherein the label is 67 Cu.
Claim 21
Dependent Claim
12 words
A method as in claim 15 wherein the label is 66 Ni.
Claim 22
Dependent Claim
12 words
A method as in claim 15 wherein the label is 55 Co.
Claim 23
Dependent Claim
12 words
A method as in claim 15 wherein the label is 69 Zn.
Claim 24
Dependent Claim
12 words
A method as in claim 15 wherein the label is 90 Y.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-19 | 1988-08-20 | 1989-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-19 | 1992-08-20 | 1993-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-19 | 1996-08-20 | 1997-02-19 | $7700.00 | Window Closed / Lapsed |