US4499090A
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US
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N-(5-aminomethyl-2-oxazolin-2-yl)-N'-phenylureas, compositions and use
Assignee: Cortial SA
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Filing: 1983-10-05
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Granted: 1985-02-12
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Expires: 2003-10-05
Abstract
Abstract This invention relates to new N-(5-aminomethyl-2-oxazoline-2-yl)-N'-phenylureas, the method for producing them and their application in therapy, particularly in treating convulsions, rhythm troubles, ulcerous disorders or inflammatory or edematous conditions. The products of this invention have the general formula: ##STR1## wherein R 1 and R 2 independently represent an alkyl radical of C 1 to C 4 , or a carbocyclic alkyl radical having 3 or less rings, or a carbocyclic radical having 3 or less rings; R 1 and R 2 can form, with the nitrogen atom to which they are attached, a 4 to 7 member heterocycle containing 1 or 2 nitrogen atoms and 1 or 0 oxygen atoms, said heterocycle can be substituted by R with R being an alkyl radical of C 1 to C 4 , allyl, benzyl, pyridyl, phenyl substituted or not by one or more substituents such as halogen, trihalomethyl, alkyl of C 1 to C 4 , hydroxy, or alkoxy having a C 1 to C 4 alkyl radical.
Inventors
- 👤 Marie-Helene Creuzet
- 👤 Claude Feniou
- 👤 Christian Jarry
- 👤 Gisele Prat
- 👤 Henri Pontagnier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 11:15
CPC Classifications
C; C07; C07D; C07D413/00; C07D413/02; C07D413/06; C07D263/00; C07D263/02; C07D263/08; C07D263/16; C07D263/28
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
134 words
A compound having the general formula: ##STR10## wherein R 1 and R 2 independently represent an alkyl radical of C 1 to C 4 , or a carbocyclic alkyl radical having less than 4 rings, or a carbocyclic radical having less than 4 rings; R 1 and R 2 can form, with the nitrogen atom to which they are attached, a 4 to 7 member heterocycle containing 1 or 2 nitrogen atoms and 1 or 0 oxygen atoms, said heterocycle can be substituted by R with R being an alkyl radical of C 1 to C 4 , allyl, benzyl, pyridyl, phenyl substituted or not with one or more substituents such as halogen, trihalomethyl, alkyl of C 1 to C 4 , hydroxy, or alkoxy having a C 1 to C 4 alkyl radical.
Claim 2
Dependent Claim
134 words
A compound having the general formula: ##STR10## wherein R 1 and R 2 independently represent an alkyl radical of C 1 to C 4 , or a carbocyclic alkyl radical having less than 4 rings, or a carbocyclic radical having less than 4 rings; R 1 and R 2 can form, with the nitrogen atom to which they are attached, a 4 to 7 member heterocycle containing 1 or 2 nitrogen atoms and 1 or 0 oxygen atoms, said heterocycle can be substituted by R with R being an alkyl radical of C 1 to C 4 , allyl, benzyl, pyridyl, phenyl substituted or not with one or more substituents such as halogen, trihalomethyl, alkyl of C 1 to C 4 , hydroxy, or alkoxy having a C 1 to C 4 alkyl radical.
Claim 3
Dependent Claim
31 words
A compound described in claim 1, wherein R 1 and R 2 are independently chosen from the group consisting of methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, benzyl, and phenyl.
Claim 4
Dependent Claim
29 words
A compound described in claim 1, wherein said heterocycle formed by R 1 and R 2 is chosen from the group consisting of piperidine, pyrrolidine, morpholine, tetrahydroisoquinoline, and piperazine.
Claim 5
Dependent Claim
29 words
A pharmaceutical or veterinary composition characterized in that it comprises as active principle a product as in claim 1 in association with a pharmaceutical vehicle or a suitable excipient.
Claim 6
Dependent Claim
20 words
A method for treating cardiac rhythm troubles which comprises administration of an effective amount of a compound of claim 1.
Claim 7
Dependent Claim
18 words
A method for treating epilepsy which comprises administration of an effective amount of a compound of claim 1.
Claim 8
Dependent Claim
18 words
A method for treating convulsions which comprises administration of an effective amount of a compound of claim 1.
Claim 9
Dependent Claim
19 words
A method for treating ulcerous disorders which comprises administration of an effective amount of a compound of claim 1.
Claim 10
Dependent Claim
19 words
A method for treating inflammatory conditions which comprises administration of an effective amount of a compound of claim 1.
Claim 11
Dependent Claim
19 words
A method for treating edematous conditions which comprises administration of an effective amount of a compound of claim 1.
References Cited (Backward Citations)
US3299089A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-12 | 1988-08-13 | 1989-02-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-12 | 1992-08-13 | 1993-02-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-12 | 1996-08-13 | 1997-02-12 | $7700.00 | Window Closed / Lapsed |