US4499077A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-microbial compositions and associated methods for preparing the same and for the disinfecting of various objects
Assignee: Individual
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Filing: 1983-03-01
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Granted: 1985-02-12
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Expires: 2003-03-01
Abstract
Abstract An anti-microbial composition is provided comprising an aqueous solution of an oxyhalogen compound and a polymeric germicide. The oxyhalogen compound is preferably stabilized chlorine dioxide and the polymeric germicide is preferably a quaternary ammonium compound such as a copolymer of at least one difunctional tertiary amine and a dihalo organic compound such as 1,4-dihalo-2-butene, a copolymer of at least one difunctional tertiary amine, at least one monofunctional tertiary amine and a dihalo organic compound such as 1,4-dihalo-2-butene, or a polyguanide such as hydrochloride salt of poly(hexamethylene biguanide). The anti-microbial composition thus formed is used for the treatment of soft contact lenses to disinfect the same with an optimum effect while minimizing the irritant possibilities thereof and also minimizing absorption of the composition into the porous and hydrophilic surfaces of soft contact lenses such that there is a minimal release of absorbed substances after treatment.
Inventors
- 👤 Richard F. Stockel
- 👤 Murray Jelling
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 00:37
CPC Classifications
A; A61; A61L; A61L12/00; A61L12/08; A61L12/14; A61L12/143; A61L12/145; A01; A01N; A01N59/00; A61L12/10; A61L12/102
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
205 words
An anti-microbial composition suitable for disinfecting lenses comprising in aqueous solution 0.001 to 0.05% by weight of an oxidizing compound which is stabilized chlorine dioxide and 0.001 to 0.05% by weight of a polymeric germicide selected from the group consisting of, (a) an anti-microbial polymeric quaternary ammonium compound made by condensing a mixture of two or more difunctional tertiary amines and a molar quantity of 1,4-dichloro-2-butene that is equal to the molar sum of the difunctional tertiary amines in the mixture, the difunctional tertiary amines being of the type ##STR9## where Z consists of from one to three divalent aliphatic radicals of 2 to 10 carbon atoms which may contain 0 to 2 double bonds or 0 to 2 hydroxy substituents, wherein R' and R" are either the same or different and wherein they be (i) primary or secondary alkyls having 1 to 20 carbon atoms, where the sum of the carbon atoms in R' and R" is no greater than 36, (ii) hydroxy or dihydroxy derivatives of the aforesaid primary or secondary alkyls, (iii) benzyl, (iv) alkyl benzyl or (v) combined with N to form a heterocyclic group of either 5, 6, or 7 atoms, and (b) a polydiguanide which is polymeric hexamethylene diguanide.
Claim 2
Dependent Claim
205 words
An anti-microbial composition suitable for disinfecting lenses comprising in aqueous solution 0.001 to 0.05% by weight of an oxidizing compound which is stabilized chlorine dioxide and 0.001 to 0.05% by weight of a polymeric germicide selected from the group consisting of, (a) an anti-microbial polymeric quaternary ammonium compound made by condensing a mixture of two or more difunctional tertiary amines and a molar quantity of 1,4-dichloro-2-butene that is equal to the molar sum of the difunctional tertiary amines in the mixture, the difunctional tertiary amines being of the type ##STR9## where Z consists of from one to three divalent aliphatic radicals of 2 to 10 carbon atoms which may contain 0 to 2 double bonds or 0 to 2 hydroxy substituents, wherein R' and R" are either the same or different and wherein they be (i) primary or secondary alkyls having 1 to 20 carbon atoms, where the sum of the carbon atoms in R' and R" is no greater than 36, (ii) hydroxy or dihydroxy derivatives of the aforesaid primary or secondary alkyls, (iii) benzyl, (iv) alkyl benzyl or (v) combined with N to form a heterocyclic group of either 5, 6, or 7 atoms, and (b) a polydiguanide which is polymeric hexamethylene diguanide.
Claim 3
Dependent Claim
33 words
An anti-microbial composition as claimed in claim 1 wherein the stabilized chlorine dioxide is an addition compound with the approximate formula of 2Na 2 CO 3 .3H 2 O 2 .ClO 2 .
Claim 4
Dependent Claim
16 words
An anti-microbial composition as claimed in claim 1 wherein the polymeric germicide is polymeric hexamethylene diguanide.
Claim 5
Independent Claim
213 words
A method comprising treating soft contact lenses by contacting the same with an aqueous solution of from 0.001 to 0.05% by weight of an oxidizing compound which is stabilized chlorine dioxide and from 0.001 to 0.05% by weight of a polymeric germicide selected from the group consisting of (a) an anti-microbial polymeric quaternary ammonium compound made by condensing a mixture of two or more difunctional tertiary amines and a molar quantity of 1,4-dichloro-2-butene that is equal to the molar sum of the difunctional tertiary amines in the mixture, the difunctional tertiary amines being of the type ##STR10## where Z consists of from one to three divalent aliphatic radicals of 2 to 10 carbon atoms which may contain 0 to 2 double bonds or 0 to 2 hydroxy substituents, wherein R' and R" are either the same or different and wherein they may be (i) primary or secondary alkyls having 1 to 20 carbon atoms, where the sum of the carbon atoms in R' and R" is no greater than 36, (iii) hydroxy or dihydroxy derivatives of the aforesaid primary or secondary alkyls, (iii) benzyl, (iv) alkyl benzyl or (v) combined with N to form a heterocyclic group of either 5, 6, or 7 atoms, and (b) a polydiguanide which is polymeric hexamethylene diguanide.
Claim 6
Independent Claim
213 words
A method comprising treating soft contact lenses by contacting the same with an aqueous solution of from 0.001 to 0.05% by weight of an oxidizing compound which is stabilized chlorine dioxide and from 0.001 to 0.05% by weight of a polymeric germicide selected from the group consisting of (a) an anti-microbial polymeric quaternary ammonium compound made by condensing a mixture of two or more difunctional tertiary amines and a molar quantity of 1,4-dichloro-2-butene that is equal to the molar sum of the difunctional tertiary amines in the mixture, the difunctional tertiary amines being of the type ##STR10## where Z consists of from one to three divalent aliphatic radicals of 2 to 10 carbon atoms which may contain 0 to 2 double bonds or 0 to 2 hydroxy substituents, wherein R' and R" are either the same or different and wherein they may be (i) primary or secondary alkyls having 1 to 20 carbon atoms, where the sum of the carbon atoms in R' and R" is no greater than 36, (iii) hydroxy or dihydroxy derivatives of the aforesaid primary or secondary alkyls, (iii) benzyl, (iv) alkyl benzyl or (v) combined with N to form a heterocyclic group of either 5, 6, or 7 atoms, and (b) a polydiguanide which is polymeric hexamethylene diguanide.
Claim 7
Dependent Claim
15 words
A method as claimed in claim 4 wherein the polymeric germicide is polymeric hexamethylene diguanide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-12 | 1988-08-13 | 1989-02-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-12 | 1992-08-13 | 1993-02-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-12 | 1996-08-13 | 1997-02-12 | $7700.00 | Window Closed / Lapsed |