US4499067A
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Oral compositions comprising NG -acyl derivatives of arginine
Assignee: Johnson and Johnson Consumer Inc
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Filing: 1982-08-26
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Granted: 1985-02-12
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Expires: 2002-08-26
Abstract
Abstract Oral hygiene formulations incorporating N G -acyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.
Inventors
- 👤 Steven B. Silbering
- 👤 Tibor Sipos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 04:58
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
26 words
N G -acyl derivatives of arginine having the formula: ##STR6## where y is an integer of from 0 to 28, and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
26 words
N G -acyl derivatives of arginine having the formula: ##STR6## where y is an integer of from 0 to 28, and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
39 words
A compound of claim 1 wherein said pharmaceutically acceptable salts are selected from the group consisting of alkali metal salts, alkaline earth metal salts, amphoteric metal salts, heavy metal salts, organic base salts, and organic and inorganic acid salts.
Claim 4
Dependent Claim
17 words
The compound of claim 1 wherein said N G -acyl derivative of arginine is N G -octanoylarginine.
Claim 5
Dependent Claim
17 words
The compound of claim 1 wherein said N G -acyl derivative of arginine is N G -nonanoylarginine.
Claim 6
Dependent Claim
17 words
The compound of claim 1 wherein said N G -acyl derivative of arginine is N G -decanoylarginine.
Claim 7
Dependent Claim
17 words
The compound of claim 1 wherein said N G -acyl derivative of arginine is N G -undecanoylarginine.
Claim 8
Dependent Claim
17 words
The compound of claim 1 wherein said N G -acyl derivative of arginine is N G -lauroylarginine.
Claim 9
Dependent Claim
17 words
The compound of claim 1 wherein said N G -acyl derivative of arginine is N G -myristoylarginine.
Claim 10
Dependent Claim
17 words
The compound of claim 1 wherein said N G -acyl derivative of arginine is N G -palmitoylarginine.
Claim 11
Dependent Claim
17 words
The compound of claim 1 wherein said N G -acyl derivative of arginine is N G -stearoylarginine.
Claim 12
Dependent Claim
17 words
The compound of claim 1 wherein said N G -acyl derivative of arginine is N G -eicosanoylarginine.
Claim 13
Dependent Claim
54 words
A composition of matter for oral hygiene to inhibit acid production by microorganisms in the oral cavity comprising an effective amount, in a pharmaceutically acceptable carrier, of an N G -acyl derivative of arginine having the formula; ##STR7## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 14
Dependent Claim
54 words
A composition of matter for oral hygiene to inhibit acid production by microorganisms in the oral cavity comprising an effective amount, in a pharmaceutically acceptable carrier, of an N G -acyl derivative of arginine having the formula; ##STR7## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 15
Dependent Claim
19 words
The composition of matter of claim 12 wherein said N G -acyl derivative of arginine is N G -octanoylarginine.
Claim 16
Dependent Claim
19 words
The composition of matter of claim 12 wherein said N G -acyl derivative of arginine is N G -nonanoylarginine.
Claim 17
Dependent Claim
19 words
The composition of matter of claim 12 wherein said N G -acyl derivative of arginine is N G -decanoylarginine.
Claim 18
Dependent Claim
19 words
The composition of matter of claim 12 wherein said N G -acyl derivative of arginine is N G -undecanoylarginine.
Claim 19
Dependent Claim
19 words
The composition of matter of claim 12 wherein said N G -acyl derivative of arginine is N G -lauroylarginine.
Claim 20
Dependent Claim
19 words
The composition of matter of claim 12 wherein said N G -acyl derivative of arginine is N G -myristoylarginine.
Claim 21
Dependent Claim
19 words
The composition of matter of claim 12 wherein said N G -acyl derivative of arginine is N G -palmitoylarginine.
Claim 22
Dependent Claim
19 words
The composition of matter of claim 12 wherein said N G -acyl derivative of arginine is N G -stearoylarginine.
Claim 23
Dependent Claim
19 words
The composition of matter of claim 12 wherein said N G -acyl derivative of arginine is N G -eicosanoylarginine.
Claim 24
Dependent Claim
15 words
The composition of matter of claim 12 wherein said pharmaceutically acceptable carrier is a dentifrice.
Claim 25
Dependent Claim
15 words
The composition of matter of claim 12 wherein said pharmaceutically acceptable carrier is a lozenge.
Claim 26
Dependent Claim
61 words
A composition of matter for oral hygiene to inhibit the formation of caries comprising, in a pharmaceutically acceptable carrier, from about 0.0001% to about 10% of a fluoride salt and an effective amount of a N G -acyl derivative of arginine having the formula: ##STR8## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 27
Dependent Claim
61 words
A composition of matter for oral hygiene to inhibit the formation of caries comprising, in a pharmaceutically acceptable carrier, from about 0.0001% to about 10% of a fluoride salt and an effective amount of a N G -acyl derivative of arginine having the formula: ##STR8## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 28
Dependent Claim
15 words
The composition of matter of claim 24 wherein said pharmaceutically acceptable carrier is a mouthrinse.
Claim 29
Dependent Claim
15 words
The composition of matter of claim 24 wherein said pharmaceutically acceptable carrier is a dentifrice.
Claim 30
Dependent Claim
66 words
A composition of matter for oral hygiene to inhibit the formation of caries comprising from about 0.05 to about 10% of N G -acyl derivative of arginine having the formula: ##STR9## wherein y is an integer of from 4 to 18, or a pharmaceutically acceptable salt thereof, in combination with from about 0.001 to about 1.0% of a fluoride salt in a pharmaceutically acceptable polyol-containing vehicle.
Claim 31
Dependent Claim
66 words
A composition of matter for oral hygiene to inhibit the formation of caries comprising from about 0.05 to about 10% of N G -acyl derivative of arginine having the formula: ##STR9## wherein y is an integer of from 4 to 18, or a pharmaceutically acceptable salt thereof, in combination with from about 0.001 to about 1.0% of a fluoride salt in a pharmaceutically acceptable polyol-containing vehicle.
Claim 32
Dependent Claim
19 words
The composition of matter of claim 27 wherein said N G -acyl derivative of arginine is N G -lauroylarginine.
Claim 33
Dependent Claim
19 words
The composition of matter of claim 27 wherein said N G -acyl derivative of arginine is N G -myristoylarginine.
Claim 34
Independent Claim
55 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity in a pharmaceutically acceptable carrier, an effective amount of an N G -acyl derivative of arginine having the formula: ##STR10## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 35
Independent Claim
55 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity in a pharmaceutically acceptable carrier, an effective amount of an N G -acyl derivative of arginine having the formula: ##STR10## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 36
Independent Claim
69 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity a composition comprising, in a pharmaceutically acceptable carrier, from about 0.0001% to about 10% of a fluoride salt and an effective amount of an N G -acyl derivative of arginine having the formula: ##STR11## wherein y is an integer of from 6 to 29, or a pharmaceutically acceptable salt thereof.
Claim 37
Independent Claim
69 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity a composition comprising, in a pharmaceutically acceptable carrier, from about 0.0001% to about 10% of a fluoride salt and an effective amount of an N G -acyl derivative of arginine having the formula: ##STR11## wherein y is an integer of from 6 to 29, or a pharmaceutically acceptable salt thereof.
Claim 38
Independent Claim
74 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity a composition comprising from about 0.05 to about 10% of N G -acyl derivative of arginine having the formula: ##STR12## wherein y is an integer of from 4 to 18, or a pharmaceutically acceptable salt thereof, in combination with from about 0.001 to about 1.0% of a fluoride salt in a pharmaceutically acceptable polyol-containing vehicle.
Claim 39
Independent Claim
74 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity a composition comprising from about 0.05 to about 10% of N G -acyl derivative of arginine having the formula: ##STR12## wherein y is an integer of from 4 to 18, or a pharmaceutically acceptable salt thereof, in combination with from about 0.001 to about 1.0% of a fluoride salt in a pharmaceutically acceptable polyol-containing vehicle.
References Cited (Backward Citations)
US2772203A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-12 | 1988-08-13 | 1989-02-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-12 | 1992-08-13 | 1993-02-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-12 | 1996-08-13 | 1997-02-12 | $7700.00 | Window Closed / Lapsed |