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US4497158A Expired / Lapsed US ⏱️ 0.0 years remaining

Process for filling pharmaceutical products highly viscous at room temperature into hard capsules

Assignee: ANATTERMANN & CIE NATTERMANNALLEE 1 D-5000 KOLN 30 GmbH
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Filing: 1981-06-02
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Granted: 1985-02-05
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Expires: 2001-06-02
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Abstract

Abstract The present invention is related to a process for filling pharmaceutical products which are highly viscous at room temperature, into hard capsules by admixing to such products a solvent or mixture of solvents in particular amounts, said solvent or solvent mixture having particular evaporation properties, and ejecting the resulting product from a usual filler nozzle under particular conditions, and closing the filled capsule with its cap.

Inventors

  • 👤 Manfred Durr
  • 👤 Hans-Ulrich Fribolin

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-08 02:21
CPC Classifications
A; A61; A61J; A61J3/00; A61J3/07; A61J3/071; A61J3/074

Claims Analysis

Total Claims: 3
Claim 1
Independent Claim 204 words
Process for filling pharmaceutical products which are highly viscous at room temperature into hard gelatin capsules comprising admixing a solvent volatile at normal pressure or a mixture of several such solvents to the highly viscous product in such an amount that the resulting product at room temperature or slightly elevated temperature has a viscosity just sufficient to allow the transport thereof with pressure, or a slightly lower viscosity, ejecting this resulting product with pressure and heating of the product before ejection from a filler nozzle arranged with its opening opposite to the opening of the hard capsule half to be filled, said heating being sufficient to cause evaporation of admixed solvent or solvent mixture from the resulting product after it is ejected from the filler nozzle, filling the hard capsule half while simultaneously evaporating admixed solvent or solvent mixture as the resulting product is filled into the hard capsule half, and closing the filled hard capsule half with the other hard capsule half, the heating and admixed solvent content being such that substantially all of the admixed solvent evaporates between product ejection from the filler nozzle and capsule closing to produce a capsule filling which is substantially solidified and substantially devoid of admixed solvent.
Claim 2
Dependent Claim 204 words
Process for filling pharmaceutical products which are highly viscous at room temperature into hard gelatin capsules comprising admixing a solvent volatile at normal pressure or a mixture of several such solvents to the highly viscous product in such an amount that the resulting product at room temperature or slightly elevated temperature has a viscosity just sufficient to allow the transport thereof with pressure, or a slightly lower viscosity, ejecting this resulting product with pressure and heating of the product before ejection from a filler nozzle arranged with its opening opposite to the opening of the hard capsule half to be filled, said heating being sufficient to cause evaporation of admixed solvent or solvent mixture from the resulting product after it is ejected from the filler nozzle, filling the hard capsule half while simultaneously evaporating admixed solvent or solvent mixture as the resulting product is filled into the hard capsule half, and closing the filled hard capsule half with the other hard capsule half, the heating and admixed solvent content being such that substantially all of the admixed solvent evaporates between product ejection from the filler nozzle and capsule closing to produce a capsule filling which is substantially solidified and substantially devoid of admixed solvent.
Claim 3
Dependent Claim 41 words
Process according to claim 1 wherein the volatile solvent or solvent mixture has a boiling point between 25° and 110° C. and it is used in an amount of from 0.5 to 10% of the weight of the highly viscous product.

References Cited (Backward Citations)

US3126321A Cited
US2837881A Cited
US3780195A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1988-02-05 1988-08-06 1989-02-05 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1992-02-05 1992-08-06 1993-02-05 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1996-02-05 1996-08-06 1997-02-05 $7700.00 Window Closed / Lapsed

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