Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
260 words
A method of treating psoriasis in a patient in need thereof which comprises administering to said patient an effective amount of a compound of the formula ##STR28## wherein Y is FCH 2 --, F 2 CH--, F 3 C--, ClCH 2 --, or Cl 2 CH--; Z is γ-guanidinopropyl or R a HN(CH 2 ) n --; n is the integer 3 or 4; each of R a and R b is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or the group ##STR29## wherein R 2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; and R 1 is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR 4 R 5 wherein each R 4 and R 5 is hydrogen or a lower alkyl group of from 1 to 4 carbon atoms, or the group ##STR30## wherein R 3 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; with the provisos that when Z is γ-guanidinopropyl, Y is FCH 2 --, F 2 CH--, or F 3 C-- and R 1 is hydroxy; and the lactams thereof when Z is R a HN(CH 2 ) n -- and each of R a and R b is hydrogen; and pharmaceutically acceptable salts and individual optical isomers thereof.
Claim 2
Independent Claim
260 words
A method of treating psoriasis in a patient in need thereof which comprises administering to said patient an effective amount of a compound of the formula ##STR28## wherein Y is FCH 2 --, F 2 CH--, F 3 C--, ClCH 2 --, or Cl 2 CH--; Z is γ-guanidinopropyl or R a HN(CH 2 ) n --; n is the integer 3 or 4; each of R a and R b is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or the group ##STR29## wherein R 2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; and R 1 is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR 4 R 5 wherein each R 4 and R 5 is hydrogen or a lower alkyl group of from 1 to 4 carbon atoms, or the group ##STR30## wherein R 3 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; with the provisos that when Z is γ-guanidinopropyl, Y is FCH 2 --, F 2 CH--, or F 3 C-- and R 1 is hydroxy; and the lactams thereof when Z is R a HN(CH 2 ) n -- and each of R a and R b is hydrogen; and pharmaceutically acceptable salts and individual optical isomers thereof.
Claim 3
Dependent Claim
10 words
The method of claim 1 wherein R 1 is hydroxy.
Claim 4
Dependent Claim
15 words
The method of claim 2 wherein Z is R a HN(CH 2 ) n --.
Claim 5
Dependent Claim
15 words
The method of claim 3 wherein each of R a and R b is hydrogen.
Claim 6
Dependent Claim
15 words
The method of claim 3 wherein Y is F 2 CH-- or FCH 2 --.
Claim 7
Dependent Claim
15 words
The method of claim 1 wherein Y is F 2 CH-- or FCH 2 --.
Claim 8
Dependent Claim
16 words
The method of claim 1 which comprises administering 2-difluoromethyl-2,5-diaminovaleric acid or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
16 words
The method of claim 1 which comprises administering 2-fluoromethyl-2,5-diaminovaleric acid or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
16 words
The method of claim 1 which comprises administering 2-chloromethyl-2,6-diaminocaproic acid or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
16 words
The method of claim 1 which comprises administering 2-difluoromethyl-2,6-diaminocaproic acid or a pharmaceutically acceptable salt thereof.