US4495190A
Expired / Lapsed
US
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Derivatives of guanine for combating herpes virus infections
Assignee: Astra Lakemedel AB
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Filing: 1982-10-25
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Granted: 1985-01-22
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Expires: 2002-10-25
Abstract
Abstract Novel antiviral compounds of the formula ##STR1## wherein each of R 1 and R 2 , which are the same or different is hydrogen, hydroxy or fluoro; provided that R 1 or R 2 is hydrogen when R 1 and R 2 are different, and provided that R 1 and R 2 are hydroxy or fluoro when R 1 and R 2 are the same; or a physiologically acceptable salt or an optical isomer thereof, methods for their preparation, pharmaceutical preparations containing the compounds, and methods for the treatment of virus infections and other diseases caused by viruses.
Inventors
- 👤 Curt-Erik Hagberg
- 👤 Karl N. Johansson
- 👤 Zsuzsanna M. I. Kovacs
- 👤 Goran B. Stening
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 11:35
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/02; C07D307/26; C07D307/30; C07D307/32; C07D307/33; A; A61; A61P; A61P31/00; A61P31/12; C07D473/00
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
74 words
A compound of the formula ##STR41## wherein each of R 1 and R 2 , which are the same or different is hydrogen, hydroxy or fluoro; provided that R 1 or R 2 is hydrogen when R 1 and R 2 are different, and provided that R 1 and R 2 are hydroxy or fluoro when R 1 and R 2 are the same; or a physiologically acceptable salt or an optical isomer thereof.
Claim 2
Dependent Claim
74 words
A compound of the formula ##STR41## wherein each of R 1 and R 2 , which are the same or different is hydrogen, hydroxy or fluoro; provided that R 1 or R 2 is hydrogen when R 1 and R 2 are different, and provided that R 1 and R 2 are hydroxy or fluoro when R 1 and R 2 are the same; or a physiologically acceptable salt or an optical isomer thereof.
Claim 3
Dependent Claim
7 words
A compound according to claim 1; 9-(3,4-dihydroxybutyl)guanine.
Claim 4
Dependent Claim
7 words
A compound according to claim 1; 9-(2,4-dihydroxybutyl)guanine.
Claim 5
Dependent Claim
14 words
A compound according to claim 1; 9-(2,3,4-trihydroxybutyl)guanine, optionally as the erythro or threo form.
Claim 6
Dependent Claim
16 words
A compound of the formula: ##STR42## or a physiologically acceptable salt or an optical isomer thereof.
Claim 7
Dependent Claim
16 words
A compound of the formula: ##STR42## or a physiologically acceptable salt or an optical isomer thereof.
Claim 8
Dependent Claim
16 words
A compound of the formula: ##STR43## or a physiologically acceptable salt or an optical isomer thereof.
Claim 9
Dependent Claim
16 words
A compound of the formula: ##STR43## or a physiologically acceptable salt or an optical isomer thereof.
Claim 10
Dependent Claim
16 words
A compound of the formula: ##STR44## or a physiologically acceptable salt or an optical isomer thereof.
Claim 11
Dependent Claim
16 words
A compound of the formula: ##STR44## or a physiologically acceptable salt or an optical isomer thereof.
Claim 12
Dependent Claim
23 words
A compound according to one of claims 1, 2, 3, 4, 5, 6 or 7 in the form of an optical isomer thereof.
Claim 13
Dependent Claim
24 words
A compound according to one of claims 1, 2, 3, 4, 5, 6 or 7 in the form of a physiologically acceptable salt thereof.
Claim 14
Dependent Claim
93 words
A pharmaceutical preparation for combating herpes infections comprising as an active ingredient a compound of the formula ##STR45## wherein each of R 1 and R 2 , which are the same or different is hydrogen, hydroxy or fluoro; provided that R 1 or R 2 is hydrogen when R 1 and R 2 are different, and provided that R 1 and R 2 are hydroxy or fluoro when R 1 and R 2 are the same; or a physiologically acceptable salt or an optical isomer thereof; in conjunction with a pharmaceutically acceptable carrier.
Claim 15
Dependent Claim
93 words
A pharmaceutical preparation for combating herpes infections comprising as an active ingredient a compound of the formula ##STR45## wherein each of R 1 and R 2 , which are the same or different is hydrogen, hydroxy or fluoro; provided that R 1 or R 2 is hydrogen when R 1 and R 2 are different, and provided that R 1 and R 2 are hydroxy or fluoro when R 1 and R 2 are the same; or a physiologically acceptable salt or an optical isomer thereof; in conjunction with a pharmaceutically acceptable carrier.
Claim 16
Dependent Claim
11 words
A pharmaceutical preparation according to claim 10 designed for systemic administration.
Claim 17
Dependent Claim
11 words
A pharmaceutical preparation according to claim 10 designed for topical administration.
Claim 18
Independent Claim
100 words
A method for the treatment of herpes virus infections in an animal or human host in need of treatment, comprising administering a therapeutically effective amount of a compound of the formula ##STR46## wherein each of R 1 and R 2 , which are the same or different is hydrogen, hydroxy or fluoro; provided that R 1 or R 2 is hydrogen when R 1 and R 2 are different, and provided that R 1 and R 2 are hydroxy or fluoro when R 1 and R 2 are the same; or a physiologically acceptable salt or an optical isomer thereof.
Claim 19
Independent Claim
100 words
A method for the treatment of herpes virus infections in an animal or human host in need of treatment, comprising administering a therapeutically effective amount of a compound of the formula ##STR46## wherein each of R 1 and R 2 , which are the same or different is hydrogen, hydroxy or fluoro; provided that R 1 or R 2 is hydrogen when R 1 and R 2 are different, and provided that R 1 and R 2 are hydroxy or fluoro when R 1 and R 2 are the same; or a physiologically acceptable salt or an optical isomer thereof.
Claim 20
Dependent Claim
14 words
A method according to claim 13 for the treatment of infections caused by herpesviruses.
Claim 21
Dependent Claim
6 words
R-(+)-9-(3,4-dihydroxybutyl)guanine and physiologically acceptable salts thereof.
Claim 22
Dependent Claim
6 words
R-(+)-9-(3,4-dihydroxybutyl)guanine and physiologically acceptable salts thereof.
Claim 23
Dependent Claim
22 words
A pharmaceutical preparation according to claims 10, 11 or 12, comprising R-(+)-9-(3,4-dihydroxybutyl) guanine or a physiologically acceptable salt thereof as active ingredient.
Claim 24
Dependent Claim
20 words
A method according to claim 13, comprising administering a therepeutically effective amount of R-(+)-9-(3,4-dihydroxybutyl)guanine or a physiologically acceptable salt thereof.
Claim 25
Dependent Claim
22 words
A pharmaceutical preparation according to claims 10, 11 or 12, comprising 9-(3,4-dihydroxybutyl) guanine or a physiologically acceptable salt thereof as active ingredient.
Claim 26
Dependent Claim
22 words
A pharmaceutical preparation according to claims 10, 11 or 12, comprising 9-(2,4-dihydroxybutyl) guanine or a physiologically acceptable salt thereof as active ingredient.
Claim 27
Dependent Claim
22 words
A pharmaceutical preparation according to claims 10, 11 or 12, comprising 9-(2,3,4-trihydroxybutyl) guanine or a physiologically acceptable salt thereof as active ingredient.
Claim 28
Dependent Claim
22 words
A pharmaceutical preparation according to claims 10, 11 or 12, comprising 9-(3-fluoro-4-hydroxybutyl) guanine or a physiologically acceptable salt thereof as active ingredient.
Claim 29
Dependent Claim
22 words
A pharmaceutical preparation according to claims 10, 11 or 12, comprising 9-(2-fluoro-4-hydroxybutyl) guanine or a physiologically acceptable salt thereof as active ingredient.
Claim 30
Dependent Claim
22 words
A pharmaceutical preparation according to claims 10, 11 or 12, comprising 9-(2,3-difluoro-4-hydroxybutyl) guanine or a physiologically acceptable salt thereof as active ingredient.
Claim 31
Dependent Claim
21 words
A method according to claim 13, comprising administering a therapeutically effective amount of 9-(3,4-dihydroxybutyl) guanine or a physiologically acceptable salt thereof.
Claim 32
Dependent Claim
21 words
A method according to claim 13, comprising administering a therapeutically effective amount of 9-(2,4-dihydroxybutyl) guanine or a physiologically acceptable salt thereof.
Claim 33
Dependent Claim
21 words
A method according to claim 13, comprising administering a therapeutically effective amount of 9-(2,3,4-trihydroxybutyl) guanine or a physiologically acceptable salt thereof.
Claim 34
Dependent Claim
21 words
A method according to claim 13, comprising administering a therapeutically effective amount of 9-(3-fluoro-4-hydroxybutyl) guanine or a physiologically acceptable salt thereof.
Claim 35
Dependent Claim
21 words
A method according to claim 13, comprising administering a therapeutically effective amount of 9(2-fluoro-4-hydroxybutyl) guanine or a physiologically acceptable salt thereof.
Claim 36
Dependent Claim
21 words
A method according to claim 13, comprising administering a therapeutically effective amount of 9-(2,3-difluoro-4-hydroxybutyl) guanine or a physiologically acceptable salt thereof.
Claim 37
Dependent Claim
9 words
A hydrochloride salt according to claim 1; 9-(3,4-dihydroxybutyl) guanine.
Claim 38
Dependent Claim
9 words
A hydrochloride salt according to claim 1; 9-(2,4-dihydroxybutyl) guanine.
Claim 39
Dependent Claim
9 words
A hydrochloride salt according to claim 1; 9-(2,3,4-trihydroxybutyl) guanine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-01-22 | 1988-07-23 | 1989-01-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-01-22 | 1992-07-23 | 1993-01-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-01-22 | 1996-07-23 | 1997-01-22 | $7700.00 | Window Closed / Lapsed |